Results 71 to 80 of about 2,755,980 (281)

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Prevalence of Secondary Hyperparathyroidism in Hemo- Dialysis Patients

Proceedings
Introduction: One persistent complication of chronic kidney disease is secondary hyperparathyroidism. Early diagnosis of this disease will reduce morbidity in patients undergoing hemodialysis.
Awais Amjad, Mateen Akram, Rana Muhammad Umar, Aiman Farogh Anjum, Saba Izhar   +4 more
doaj   +1 more source

Left parathyroid carcinoma with secondary hyperparathyroidism: a case report

BMC Endocrine Disorders, 2023
Background Parathyroid carcinoma is a rare disease with a frequency of 0.005% of all malignancies [1, 2]. Various aspects of its pathogenesis, diagnosis, and treatment remain poorly understood.
Ko Yokoyama, Nobuyasu Suganuma, Yasushi Rino   +2 more
doaj   +1 more source

Patient level pooled analysis of 68,500 patients from seven major vitamin D fracture trials in the US and Europe [PDF]

, 2010
Objectives To identify participants’ characteristics that influence the anti-fracture efficacy of vitamin D or vitamin D plus calcium with respect to any fracture, hip fracture, and clinical vertebral fracture and to assess the influence of dosing ...
Abrahamsen, B, Anderson, F, Avenell, A, Brixen, K, Cooper, C, F, Hutchison, Francis, R M, Jackson, R, Johansen, A, LaCroix, A Z, Masud, T, Meyer, H E, Mosekilde, L, Rejnmark, L, Robbins, J A, Smith, H, The DIPART (vitamin D Individual Patient Analysis of Randomized Trials) Group, Torgerson, D, Wactawski-Wende, J   +18 more
core   +2 more sources

Considerations and Tips for Promoting Skin Barrier Maintenance and Quality of Life in Patients With Diabetes Mellitus: An Expert Consensus

JEADV Clinical Practice, EarlyView.
ABSTRACT Skin changes such as xerosis and pruritus are common complications among diabetes patients and may lead to serious adverse events such as diabetic foot syndrome and amputations. Evidence suggests that daily application of optimal skincare, including gentle cleansers and moisturizers, may help improve skin barrier function, preventing ...
Robert S. Kirsner, Anneke Andriessen, Brian Berman, Natasha Mesinkovska, Heather Woolery‐Lloyd, Lawrence Schachner   +5 more
wiley   +1 more source

A case report of multiple giant cell granulomas related to tertiary hyperparathyroidism

مجله دانشکده دندانپزشکی اصفهان, 2013
Introduction: Excessive secretion of parathyroid hormone results in hyperparathyroidism which is classified into primary, secondary and tertiary categories.
Parviz Deyhimi, Mohammadreza Amjadi, Samaneh Shirani, Mahsa Kalantari, Maryam Jafari   +4 more
doaj  

Transient hypercortisolism and symptomatic hyperthyroidism associated to primary hyperparathyroidism in an elderly patient: case report and literature review. [PDF]

, 2015
Background: Primary hyperparathyroidism (PHPT) is often found on routine blood tests, at a relatively asymptomatic stage. However many studies suggest different systemic effects related to PHPT, which could be enhanced by an abnormal cortisol release due
Armanini, Decio, Bordin, Luciana, Camozzi, V, Don\ue0, G, Iacobone, Maurizio, Mian, Caterina, Sabbadin, Chiara   +6 more
core   +2 more sources

Reversibility of experimental secondary hyperparathyroidism

Kidney International, 1997
Chronic uremia is associated with secondary hyperparathyroidism (HPT). The purpose of the present investigation was to study the reversibility of secondary HPT after reversal of uremia by an isogenic kidney transplantation in the rat. Secondary HPT was induced in two models: Model A comprised 5/6 nephrectomized rats kept on a standard diet (N = 12; PTH
Klaus Olgaard, Ewa Lewin, Wanmei Wang
openaire   +3 more sources

Bone Health Following Lifestyle‐Induced Weight Loss in Individuals With Overweight/Obesity: A Narrative Review

Obesity, EarlyView.
ABSTRACT Although weight loss has many health benefits for people with overweight/obesity, its potential negative impact on bone health needs to be considered. This review provides a comprehensive overview of the effects of intentional weight loss achieved by lifestyle changes on bone health outcomes in adults with overweight/obesity and discusses ...
Mélanie A. Legrand, Julien Paccou, Jean‐Michel Lecerf, Thierry Thomas, Roland Chapurlat, Bernard Cortet, Emmanuel Biver, Maria Papageorgiou   +7 more
wiley   +1 more source

Generalised osteitis fibrosa cystica due to secondary hyperparathyroidism in chronic kidney disease

Journal of College of Medical Sciences-Nepal, 2014
Secondary hyperparathyroidism is a frequent complication of patients with chronic kidney disease and is characterized by excessive serum parathyroid hormone levels and an imbalance in calcium and phosphorus metabolism.
Sundar K Shrestha, A Tayal
doaj   +1 more source