Results 111 to 120 of about 18,942 (235)

Antisense Mapping of the MOR-1 Opioid Receptor Clone: Modulation of Hyperphagia Induced by DAMGO 1 [PDF]

, 2020
The mu opioid receptor mediates ingestive behavior: muselective agonists stimulate food intake and antagonists reduce intake in many ingestive situations.
Liza Leventhal, Richard J Bodnar, Lesley B Stevens, Grace C Rossi, Gavril W Pasternak   +4 more
core  

Genotype–Phenotype Spectrum of Non‐Syndromic Monogenic Obesity in a National Paediatric Cohort

Pediatric Obesity, Volume 21, Issue 6, June 2026.
ABSTRACT Objective Non‐syndromic monogenic obesity, caused by defects in the leptin‐melanocortin pathway, presents with early‐onset severe obesity and hyperphagia, but genotype–phenotype and metabolic correlations across different genetic forms remain unclear.
Ahmet Kahveci, Selin Uzun Karauzum, Hayrullah Manyas, Behiye Sarikaya Ozdemir, Zerrin Orbak, Ummahan Tercan, Ruken Yildirim, Nihal Hatipoglu, Fatih Kilci, Hatice Nursoy, Servan Ozalkak, Baris Kolbasi, Semra Cetinkaya, Hazal Canbaz Ozdemir, Mesut Parlak, Filiz Tutunculer Kokenli, Emine Camtosun, Saime Ergen Dibeklioglu, Gonul Buyukyilmaz, Ayse Derya Bulus, Hanife Gul Balki, Ayse Ozden, E. Nazli Gonc, Elif Ozsu, Huseyin Demirbilek, Melek Yildiz, Samim Ozen, Abdullah Bereket, Belma Haliloglu   +28 more
wiley   +1 more source

Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi, Ali Saeedi‐Boroujeni, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +4 more
wiley   +1 more source

Values of Individuals With Rare Genetic Neurodevelopmental Disorders and Their Family/Caregivers in Healthcare: A Scoping Review to Inform Guideline Development

Journal of Intellectual Disability Research, Volume 70, Issue 6, Page 608-652, June 2026.
ABSTRACT Background Healthcare decision‐making for individuals with rare genetic neurodevelopmental disorders (RGNDs) associated with intellectual disabilities (ID) can be complex due to the intersection of lifelong care needs, limited medical expertise and communication barriers.
Mirthe J. Klein Haneveld, Louise Cox, Petri J. C. M. Embregts, Alistair R. Niemeijer, Martina C. Cornel, Charlotte M. W. Gaasterland, Agnies M. van Eeghen   +6 more
wiley   +1 more source

Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats

, 2014
Excessive weight gain is a major metabolic side effect of second-generation antipsychotics (SGAs) in the treatment of schizophrenia. Ghrelin is an orexigenic hormone secreted mainly from the stomach, which can induce weight gain and hyperphagia through ...
Meng He (20118228), Qingsheng Zhang (20122938), Jiamei Lian (19586263), Chao Deng (19586473), Xu-Feng Huang (19584460), Hongqin Wang (20121813)   +5 more
core  

Brainstem Astrocytes Regulate Estrus‐Dependent Oscillations in Food Intake

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
DVC astrocytes regulate food intake and caloric balance via modulation of NMDA receptor‐mediated glutamatergic signaling to brainstem DMV motoneurons. In female rats, GFAP‐IR intensity and astrocyte morphological complexity increased during periods of high estrogen levels when food intake was decreased, and chemogenetic manipulation of DVC astrocytes ...
K. Selin Ozkaya, Ceyda Yalcin, Emily E. Haar, Ruchi Bhagat, Kirsteen N. Browning   +4 more
wiley   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

Improving the diagnosis of hyperphagia in melanocortin‐4 receptor pathway diseases

Characteristics of hyperphagia include heightened and prolonged hunger, longer time to satiation, shorter duration of satiety, severe preoccupation with food (i.e., hyperphagic drive), abnormal food-seeking behaviors, and distress or functional ...
Haqq, Andrea, Yanovski, Jack A, Goldstone, Anthony, Abuzzahab, M Jennifer, Yanovski, Jack, Abuzzahab, M. Jennifer, Miller, Jennifer L, Miller, Jennifer, Goldstone, Anthony P, Wabitsch, Martin, Haqq, Andrea M, Heymsfield, Steven B, Heymsfield, Steven, Dubern, Beatrice, Richards, Jesse   +14 more
core   +1 more source

OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Soybean oil intake induces OPA1 expression in hypothalamic MC4R neurons, contributing to adaptive regulation of appetite. MC4R neuron‐specific OPA1 deficiency increases soybean oil consumption and leads to obesity, with a more pronounced effect in females.
Shigenobu Matsumura, Mizuki Fujiwara, Soyoka Horie, Miona Marutani, Eri Nousou, Nanase Iki, Yuka Yamato, Yui Otonashi, Tsutomu Sasaki, Mina Fujitani, Teppei Fujikawa   +10 more
wiley   +1 more source

Resource allocation, hyperphagia and compensatory growth in juveniles

, 2003
Many organisms exploit highly variable food supplies and, as an adaptation to such conditions, show elevated growth during recovery from starvation.
Nisbet, Roy M., Jones, Wayne, Jones, W., Veitch, R., Gurney, W.S.C., Gurney, William S. C., Veitch, A. Roy, Nisbet, R.M.   +7 more
core   +1 more source