Results 31 to 40 of about 15,451 (202)

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Treatment of hyperprolactinemia in women: A Position Statement from the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and the Brazilian Society of Endocrinology and Metabolism (SBEM)

Archives of Endocrinology and Metabolism
Dopamine agonists are the first line of treatment for patients with symptomatic hyperprolactinemia due to prolactinomas and in those with idiopathic hyperprolactinemia. Treatment with these agents is effective in 80%-90% of the cases.
Cristina Laguna Benetti-Pinto, Andrea Prestes Nácul, Ana Carolina Japur de Sá Rosa-e-Silva, Gustavo Arantes Rosa Maciel, Vania dos Santos Nunes Nogueira, Paula Condé Lamparelli Elias, Manoel Martins, Leandro Kasuki, Heraldo Mendes Garmes, Andrea Glezer   +9 more
doaj   +1 more source

Depression, anxiety, sexual function and quality of life in women with hyperprolactinemia [PDF]

Revista Brasileira de Ginecologia e Obstetrícia
Objective: To evaluate anxiety, depression, sexual function and quality of life in women with hyperprolactinemia. Methods: Cross-sectional study with 80 women divided into two groups: 30 women with hyperprolactinemia (Study Group) followed and treated ...
Renan Massao Nakamura, Daniela Angerame Yela, Amanda Carvalho Santos, Beatriz Cipriano Ribas, Pedro Henrique Rosa e Silva, Bianca Netto Motta, Gabriela Pravatta Rezende, Cristina Laguna Benetti-Pinto   +7 more
doaj   +1 more source

The hyperprolactinemia

Medical Journal of the Russian Federation, 2016
The hyperprolactinemia is one of the most frequent symptoms of pathology of hypophysis. This pathology is accompanied with by prolactinomas (60%), sterility (40%) galactorrhea, metabolic disorders (65%). The article deals with modern techniques of diagnostic, clinic and treatment of hyperprolactinemia in women.
Tat’yana V. Sebko, L. A Kheydar, S. S Koneeva   +2 more
openaire   +1 more source

Can Aripiprazole Normalize Yatrogenic Hyperprolactinemia?

, 2023
Aripiprazole is a second generation atypical antipsychotic (AAP), with properties of partial dopamine agonist, used in schizophrenia, bipolar disorder and depression, among others.
Roberto Lozano, Asuncion Pascual, Reyes Marin, María-Jesús Santacruz   +3 more
core   +1 more source

Diagnosis of hyperprolactinemia in women: A Position Statement from the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and the Brazilian Society of Endocrinology and Metabolism (SBEM)

Archives of Endocrinology and Metabolism
Hyperprolactinemia is a frequent cause of menstrual irregularity, galactorrhea, hypogonadism, and infertility. The most common etiologies of hyperprolactinemia can be classified as physiological, pharmacological, and pathological.
Andrea Glezer, Heraldo Mendes Garmes, Leandro Kasuki, Manoel Martins, Paula Condé Lamparelli Elias, Vania dos Santos Nunes Nogueira, Ana Carolina Japur de Sá Rosa-e-Silva, Gustavo Arantes Rosa Maciel, Cristina Laguna Benetti-Pinto, Andrea Prestes Nácul   +9 more
doaj   +1 more source

Psychopharmacological Prescribing Patterns Among Italian Adolescents With Anorexia Nervosa: Exploring Real‐World Treatment Practices

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To investigate real‐world psychopharmacological prescribing patterns among Italian adolescents with anorexia nervosa (AN) compared with psychiatric controls without eating disorders, and to examine whether AN diagnosis independently predicts medication use after accounting for psychiatric comorbidities.
Marika Orlandi, Arianna Vecchio, Giulia Andorno, Maria Pia Riccio, Cinzia Crispino, Martina Maria Mensi   +5 more
wiley   +1 more source

Teratogenicity and hyperprolactinemia

Indian Journal of Psychiatry, 2009
Byline: Chittaranjan. Andrade CME Questions A) Drugs should be prescribed with caution to women of childbearing age because of the risk of teratogenicity, should conception occur during treatment; this concern is particularly important when prescribing drugs that will be required for long periods, such as in the maintenance therapy of epilepsy, bipolar
openaire   +2 more sources

Subclinical cardiac alterations and cardiometabolic profile in adolescents with newly diagnosed polycystic ovary syndrome: A cross‐sectional comparative echocardiographic study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective While cardiometabolic comorbidities have been well established in adults with polycystic ovary syndrome (PCOS), it remains unclear whether the early signs of cardiovascular morbidity emerge during adolescence. This study aimed to investigate whether metabolic and cardiovascular alterations begin in adolescents with PCOS.
Demet Aygün Ari, Melis Pehlivantürk Kizilkan, Musa Öztürk, İlker Ertuğrul, Hayrettin Hakan Aykan, Tevfik Karagöz, Nuray Kanbur, Orhan Derman, Sinem Akgül   +8 more
wiley   +1 more source