Results 1 to 10 of about 271 (108)

Macroprolactinemia: a mini-review and update on clinical practice [PDF]

F&S Reports, 2023
Hyperprolactinemia is common among infertile patients, with up to 15%–20% of women with oligomenorrhea having hyperprolactinemia. Suppression of the hypothalamic-pituitary-gonadal axis via inhibition of pulsatile gonadotropin releasing hormone because of
Katherine G Koniares, Claudio Benadiva, Lawrence Engmann   +2 more
exaly   +4 more sources

Macroprolactinemia: Diagnostic, Clinical, and Pathogenic Significance

Clinical and Developmental Immunology, 2012
Macroprolactinemia is characterized by a large molecular mass of PRL (macroprolactin) as the main molecular form of PRL in sera, the frequent elevation of serum PRL (hyperprolactinemia), and the lack of symptoms.
Akira Shimatsu
exaly   +3 more sources

Evaluation of autoantibodies and immunoglobulin G subclasses in women with suspected macroprolactinemia [PDF]

Journal of Clinical Laboratory Analysis, 2020
To evaluate the prevalence of associated autoantibodies, as well as the IgG subclass distributions in the patients suspected for macroprolactinemia, totally 317 patients with elevated prolactin were recruited for the initial screening with the polyethylene glycol precipitation assay.
Siqi Hu, Lingxin Meng, Lu Chen
exaly   +3 more sources

Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations

International Journal of Endocrinology, 2013
Aim. To determine the frequency of macroprolactinemia, its etiology, and the clinical manifestations in patients with hyperprolactinemia presenting with menstrual irregularities, galactorrhea, and/or infertility who were attended by the gynecology ...
Alfredo Leaños-Miranda, Karla Leticia Ramírez-Valenzuela, Inova Campos-Galicia, Rosario Chang-Verdugo, Lizbeth Zarela Chinolla-Arellano   +4 more
doaj   +2 more sources

Position statement on macroprolactinemia from the Department of Neuroendocrinology of the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society of Clinical Pathology/Laboratory Medicine (SBPC/ML) [PDF]

Archives of Endocrinology and Metabolism
Measurement of serum prolactin levels is a common practice in clinical settings, particularly among women of reproductive age. In cases of hyperprolactinemia, identifying macroprolactinemia can help prevent unnecessary investigation and inappropriate ...
Andrea Glezer, Paula Condé Lamparelli Elias, Vania dos Santos Nunes Nogueira, Heraldo Mendes Garmes, Leandro Kasuki, Guilherme Alcides Flôres Soares Rollin, Manoel Ricardo Alves Martins, Adriana Caschera Leme, Pedro Saddi Rosa, Luciana Ansaneli Naves, Marcelo Cidade Batista   +10 more
doaj   +2 more sources

Establishment of reference intervals of monomeric prolactin to identify macroprolactinemia in Chinese patients with increased total prolactin [PDF]

BMC Endocrine Disorders, 2021
Background Macroprolactin is responsible for pseudohyperprolactinemia and is a common pitfall of the prolactin immunoassay. We aimed to determine the frequency of macroprolactinemia in Chinese hyperprolactinemic patients using monomeric prolactin ...
Yao Hu, Jiajin Ni, Buyue Zhang, Wei Cheng, Huating Zhang, Hongying Ye, Lijin Ji, Bin Lu, Ming Guan   +8 more
doaj   +2 more sources

The Effect of Metformin on Pituitary Function in Postmenopausal Women with Subclinical Hypothyroidism and Macroprolactinemia: A Single-Center Prospective Case–Control Study [PDF]

Pharmaceuticals
Background/Objectives: Metformin inhibits secretory function of overactive thyrotrophs, gonadotrophs, and lactotrophs. The clinical significance of an excess of high-molecular-weight prolactin (macroprolactinemia) remains unclear.
Robert Krysiak, Witold Szkróbka, Karolina Kowalcze, Bogusław Okopień   +3 more
doaj   +2 more sources

Comparison of urinary prolactin and serum/urine prolactin ratio in hyperprolactinemic and macroprolactinemic patients [PDF]

BMC Endocrine Disorders
Background Biologically, the monomeric form of prolactin is the most active. In measurement methods, all forms of prolactin are included in the assay; therefore, the presence of macroprolactin, causes a false increase in prolactin and misdiagnosis of ...
Behnam Ein-Mozaffari, Akbar Aliasgharzadeh, Farzad Najafipour, Azam Moslemi, Mitra Niafar, Vahideh Sadra, Nasser Aghamohammadzadeh, Jalil Houshyar, Halimeh Amirazad   +8 more
doaj   +2 more sources

Macroprolactinemia in patients with hyperprolactinemia: an experience from a single tertiary center [PDF]

The Pan African Medical Journal, 2020
Macroprolactinemia frequently causes misdiagnosis, unnecessary investigation and inappropriate treatment in hyperprolactinemic patients. Aim of this study is to investigate the prevalence and clinical characteristics of Thai patients with ...
Phronpan Chutpiboonwat, Kanchana Yenpinyosuk, Vitaya Sridama, Supaksorn Kunjan, Karuna Klaimukh, Thiti Snabboon   +5 more
doaj   +2 more sources

Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature

Case Reports in Endocrinology, 2016
Background. Macroprolactinemia is defined as predominance of high molecular weight prolactin forms in the circulation. Although macroprolactin is considered as a biologically inactive molecule, some authorities suggest treatment in symptomatic cases ...
Fatma Dilek Dellal, Didem Ozdemir, Cevdet Aydin, Gulfem Kaya, Reyhan Ersoy, Bekir Cakir   +5 more
doaj   +2 more sources