Results 11 to 20 of about 483 (156)

Macroprolactinemia: Diagnostic, Clinical, and Pathogenic Significance [PDF]

Clinical and Developmental Immunology, 2012
Macroprolactinemia is characterized by a large molecular mass of PRL (macroprolactin) as the main molecular form of PRL in sera, the frequent elevation of serum PRL (hyperprolactinemia), and the lack of symptoms.
Akira Shimatsu, Naoki Hattori
doaj   +7 more sources

Macroprolactinemia in childhood and adolescence: a cause of hyperprolactinemia [PDF]

The Turkish Journal of Pediatrics, 2006
Human prolactin consists of multiple forms of different sizes including three major prolactin (PRL) species, termed as little, big, and big-big PRL.
Filiz Tütüncüler, Feyza Darendeliler, Menekşe Aygün, Nezih Hekim   +3 more
doaj   +5 more sources

Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations [PDF]

International Journal of Endocrinology, 2013
Aim. To determine the frequency of macroprolactinemia, its etiology, and the clinical manifestations in patients with hyperprolactinemia presenting with menstrual irregularities, galactorrhea, and/or infertility who were attended by the gynecology ...
Alfredo Leaños-Miranda, Karla Leticia Ramírez-Valenzuela, Inova Campos-Galicia, Rosario Chang-Verdugo, Lizbeth Zarela Chinolla-Arellano   +4 more
doaj   +3 more sources

Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature [PDF]

Case Reports in Endocrinology, 2016
Background. Macroprolactinemia is defined as predominance of high molecular weight prolactin forms in the circulation. Although macroprolactin is considered as a biologically inactive molecule, some authorities suggest treatment in symptomatic cases ...
Fatma Dilek Dellal, Didem Ozdemir, Cevdet Aydin, Gulfem Kaya, Reyhan Ersoy, Bekir Cakir   +5 more
doaj   +3 more sources

Macroprolactinemia in a Patient with Invasive Macroprolactinoma: A Case Report and Minireview [PDF]

Case Reports in Endocrinology, 2013
Background. Macroprolactin, the high-molecular prolactin isoform, is considered to be an inactive in vivo product with extrapituitary origin. Patients with macroprolactinemia are usually asymptomatic, with negative pituitary imaging. Based on these data,
Atanaska Elenkova, Zdravka Abadzhieva, Nikolai Genov, Vladimir Vasilev, Georgi Kirilov, Sabina Zacharieva   +5 more
doaj   +3 more sources

The Correlation Between DRD2 and COMT Gene Polymorphisms, HPT and HPG Axes Functions, and Antipsychotic Drug-Induced Hyperprolactinemia and Macroprolactinemia [PDF]

Neuropsychiatric Disease and Treatment
Zhenhua Wang,1 Jing Li,2 Haizhi Chen,1 Haiying Jin,1 Shiliang Wang,1 Xuqiang Hu1 1Department of Psychiatry, Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, People’s Republic of China; 2Center for Disease ...
Wang Z, Li J, Chen H, Jin H, Wang S, Hu X   +5 more
doaj   +4 more sources

Macroprolactinemia: new insights in hyperprolactinemia [PDF]

Biochemia Medica, 2012
Hypersecretion of prolactin by lactotroph cells of the anterior pituitary may lead to hyperprolactinemia in physiological, pathological and idiopathic conditions. Most patients with idiopathic hyperprolactinemia may have radiologically undetected microprolactinomas, but some may present other causes of hyperprolactinemia described as macroprolactinemia.
Kasum, Miro, Oreskovic, Slavko, Zec, Ivana, Jezek, Davor, Tomic, Vlatka, Gall, Vesna, Adzic, Goran   +6 more
core   +9 more sources

Importance of macroprolactinemia in hyperprolactinemia [PDF]

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2014
Macroprolactin is an antigen-antibody complex of higher molecular mass than prolactin (>150kDa), consisting of monomeric prolactin and immunoglobulin G. The term 'macroprolactinemia' is used when the concentration of macroprolactin exceeds 60% of the total serum prolactin concentration determined by polyethylene glycol precipitation.
Kasum, Miro, Pavičić-Baldani, Dinka, Stanić, Patrik, Orešković, Slavko, Šarić, Jakov-Marko, Blajić, Jozo, Juras, Josip   +6 more
core   +7 more sources

Clinical and radiological findings in macroprolactinemia [PDF]

Endocrine, 2011
Hyperprolactinemia is the most common abnormality of the hypothalamic-pituitary axis. The aim of this study was to investigate the clinical and radiological features of patients with macroprolactinemia. The study population consisted of patients with elevated serum prolactin (PRL) concentrations who presented to our Endocrinology outpatient clinic ...
GULER, Serdar, Aydin, Yusuf, KUCUKLER, Ferit Kerim, Ozcan, HATİCE NURSUN, Erden, GÖNÜL, GOKAY, Ferhat, OZUGUZ, Ufuk, TUTUNCU, Yasemin Ates, BERKER, Dilek, ISIK, Serhat   +9 more
core   +9 more sources

Evaluation of Autoantibodies and Immunoglobulin G Subclasses in Women With Suspected Macroprolactinemia [PDF]

Journal of Clinical Laboratory Analysis, 2020
To evaluate the prevalence of associated autoantibodies, as well as the IgG subclass distributions in the patients suspected for macroprolactinemia, totally 317 patients with elevated prolactin were recruited for the initial screening with the polyethylene glycol precipitation assay.
Siqi Hu, Lu Chen
exaly   +3 more sources