Results 111 to 120 of about 126,787 (302)
Intratumoral Nerve Phased Development: A Promising Therapeutic Target
Medicine Bulletin, EarlyView.ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che +3 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Objectives The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rare tauopathy. Methods A randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted at
Jean‐Christophe Corvol +17 more
wiley +1 more source
The Development of Hypersensitivity Reactions in the Pediatric Population: A Review [PDF]
, 2019 Over the past several years, pediatric allergies have come to the forefront of many studies. Reports of immune-mediated hypersensitivity in younger patients have grown and led to an interest researching the causes of pediatric hypersensitivities.
Burns, Heather
core +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi +6 more
wiley +1 more source
Gadolinium Pollution—A Future Forward Perspective on Human and Environmental Impact
Magnetic Resonance in Medicine, EarlyView.ABSTRACT The widespread use of gadolinium‐based contrast agents (GBCAs) in magnetic resonance imaging (MRI) has been instrumental in enhancing diagnostic capabilities. However, the potential environmental and human health impacts of gadolinium pollution have become a growing concern.
Makayla R. Long +5 more
wiley +1 more source
Plant defense strategies: The dual armor of disease resistance and tolerance
New Plant Protection, EarlyView.Plants employ dual strategies against pathogens: Resistance limits invasion via immune responses, whereas tolerance mitigates damage to sustain growth—together enhancing survival under infections. Abstract Pathogen infections pose a significant threat to plant health, global food security, and ecosystems.
Zhijuan Tang +3 more
wiley +1 more source
Sensory Responses in Autistic Individuals—A Narrative Review
Sensory Neuroscience, EarlyView.Caption—Atypical sensory processing in Autism Spectrum Disorder. ABSTRACT The first clinical descriptions of autism from the late 1960s mentioned sensory dysregulation as one of the commonly reported findings among autistic individuals, yet, it was not until 2013 that they were included as part of the core symptoms of autism spectrum disorder (ASD) in ...
Anisha Kaundinya, Sowmyashree Mayur Kaku
wiley +1 more source
Relevance of the variability of the feline immunodeficiency virus in regard to pathogenicity and vaccination in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science, Massey University, Manawatū, New Zealand [PDF]
, 2018 Cats infected with the feline immunodeficiency virus (FIV) show a range of clinical signs. Given the variability of the FIV genome, it is possible that there is variation in certain biological characteristics of FIV, such as pathogenicity.
Stickney, Alison Louise
core
Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation
Small Science, EarlyView.Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen +10 more
wiley +1 more source