Results 141 to 150 of about 798,798 (261)

Cows' milk hypersensitivity: immediate and delayed onset clinical patterns.

open access: yesArchives of Disease in Childhood, 1983
R. Ford, D. Hill, C. Hosking
semanticscholar   +1 more source

Akt Activation With IPL344 Treatment for Amyotrophic Lateral Sclerosis: First in Human, Open‐Label Study

open access: yesMuscle &Nerve, Volume 71, Issue 6, Page 1032-1042, June 2025.
ABSTRACT Introduction/Aims Akt intracellular signal transduction pathway dysfunction has been reported in people with amyotrophic lateral sclerosis (ALS) providing a novel target for intervention in this devastating progressive disease. This first‐in‐human study evaluated the safety, tolerability, and preliminary efficacy of the Akt pathway activator ...
Marc Gotkine   +9 more
wiley   +1 more source

Unlocking complexity through neutron scattering: Structure and dynamics of protein–polymer conjugates

open access: yesProtein Science, Volume 34, Issue 6, June 2025.
Abstract Protein–polymer conjugates are engineered to enhance the pharmacokinetics and stability of biopharmaceuticals. This review delves into the structural and dynamic characteristics of protein–polymer conjugates, employing advanced techniques such as neutron scattering, circular dichroism, and fluorescence spectroscopy.
Daniela Russo   +2 more
wiley   +1 more source

Designer breed dogs (canis lupus familiaris) with aggression and hyperactivity

open access: yesVeterinary Record Case Reports, Volume 13, Issue 2, June 2025.
Abstract We describe two cases of designer breed dogs presented for behavioural issues to the Animal Behavioural Clinic of Utrecht University. A 1.5‐year‐old, entire cockapoo male was presented for aggression towards people, hyperactivity and separation‐related behaviour.
Silvia M. A. Gardeweg   +3 more
wiley   +1 more source

LTF as a Potential Predictive Biomarker for Durable Benefit From First‐Line Chemo‐Immunotherapy in Small Cell Lung Cancer

open access: yesCancer Science, Volume 116, Issue 6, Page 1522-1536, June 2025.
LTF as a potential biomarker for predicting the efficacy of chemo‐immunotherapy. ABSTRACT At present, only a limited fraction of patients with extensive‐stage small cell lung cancer (ES‐SCLC) achieve a sustained response to immune checkpoint blockade (ICB) therapy.
Shimo Shen   +7 more
wiley   +1 more source

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