Results 31 to 40 of about 52,142 (265)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Anaphylaxis to levetiracetam in an adolescent: a very rare occurence

The Turkish Journal of Pediatrics, 2021
Background. Antiepileptic drugs (AEDs) are among the most common causes of severe delayed-type hypersensitivity reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic ...
Şeyma Kahraman, Şeyda Değermenci, Mehmet Ali Oktay, Deniz Menderes, Okşan Derinöz Güleryüz, Ebru Arhan, Arzu Bakırtaş, Hacer İlbilge Ertoy-Karagöl   +7 more
doaj   +1 more source

Effect of Implementing a Dashboard With or Without a Best Practice Alert on HLA‐B*58:01 Testing Rates Among Allopurinol Users at VA Medical Centers

Arthritis Care &Research, EarlyView.
Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge, Gabriela Schmajuk, Sristi Sharma, Colleen P. Flanagan, Sara Faghihi‐Kashani, Ning Zhang, Mary A. Whooley   +6 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Consumer preferences for food allergen labeling

Allergy, Asthma & Clinical Immunology, 2017
Background Food allergen labeling is an important tool to reduce risk of exposure and prevent anaphylaxis for individuals with food allergies. Health Canada released a Canadian food allergen labeling regulation (2008) and subsequent update (2012 ...
Carlo A. Marra, Stephanie Harvard, Maja Grubisic, Jessica Galo, Ann Clarke, Susan Elliott, Larry D. Lynd   +6 more
doaj   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

IMMEDIATE AND DELAYED HYPERSENSITIVITY REACTIONS TO PROTON PUMP INHIBITORS: A REVIEW ARTICLE [PDF]

Sanamed
Proton pump inhibitors (PPIs) are among the most widely prescribed medications in clinical practice, primarily used for managing acid-related gastrointestinal disorders. While generally regarded as safe, with adverse effects being rare and typically mild,
Corovic Vahida, Corovic Irfan, Ademovic Vahid, Gegic Altan, Dazdarevic Zecirovic Mirzeta, Corovic Kemal, Suljic Lejla, Corovic Licina Emina, Ziljkic Vahid, Plojovic Haris, Maksic Mladen, Dzankovic Fuad, Vucelj Samir, Suljic Muamer   +13 more
doaj   +1 more source

Immediate hypersensitivity to COVID-19 vaccines: Focus on biological diagnosis

Frontiers in Allergy, 2022
Soon after the release of the new anti-COVID mRNA vaccines, reports came in from the US and the UK of anaphylactic reactions. Fueled by the necessary caution toward these new vaccine platforms, these reports had a great impact and were largely commented ...
Pascale Nicaise-Roland, Pascale Nicaise-Roland, Vanessa Granger, Vanessa Granger, Angèle Soria, Angèle Soria, Annick Barbaud, Marc Pallardy, Sylvie Chollet-Martin, Sylvie Chollet-Martin, Luc de Chaisemartin, Luc de Chaisemartin   +11 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Chlorhexidine Hypersensitivity: A Case Report of Delayed Reactions Associated with Epidermal Preparations

Plastic and Reconstructive Surgery, Global Open, 2020
Summary:. Chlorhexidine is a topical antiseptic that is generally well tolerated in patients, making it a common preparatory substance in various surgical settings.
Priya Bhardwaj, MS, Jenna C. Bekeny, BA, Elizabeth G. Zolper, BS, Manas Nigam, MD, Sarah R. Sher, MD   +4 more
doaj   +1 more source