Results 41 to 50 of about 661,856 (255)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

IMMEDIATE AND DELAYED HYPERSENSITIVITY REACTIONS TO PROTON PUMP INHIBITORS: A REVIEW ARTICLE [PDF]

Sanamed
Proton pump inhibitors (PPIs) are among the most widely prescribed medications in clinical practice, primarily used for managing acid-related gastrointestinal disorders. While generally regarded as safe, with adverse effects being rare and typically mild,
Corovic Vahida, Corovic Irfan, Ademovic Vahid, Gegic Altan, Dazdarevic Zecirovic Mirzeta, Corovic Kemal, Suljic Lejla, Corovic Licina Emina, Ziljkic Vahid, Plojovic Haris, Maksic Mladen, Dzankovic Fuad, Vucelj Samir, Suljic Muamer   +13 more
doaj   +1 more source

Practice Parameters for Diagnosing and Managing Iodinated Contrast Media Hypersensitivity. [PDF]

, 2020
Immediate and non-immediate hypersensitivity reactions to iodinated contrast media (ICM) have been reported to occur in a frequency of about 0.5-3% of patients receiving non-ionic ICM.
Kathrin Scherer, Torres, María José, Moreno, E, Patrizia Bonadonna, Francesco Gaeta, Moreno, Esther, Trautmann, A, Gimenez-Arnau, A M, Barbaud, A, Chiriac, A, Bavbek, Sevim, Gimenez-Arnau, Ana M, Anca Mirela Chiriac, Kang, Hye‐ryun, María José Torres, Cernadas, Josefina Rodrigues, Brockow, Knut, Brockow, K, Scherer, Kathrin, Rodrigues-Cernadas, Josefina, Gimenez-Arnau, Ana, Chiriac, Anca Mirela, Bavbek, S, Cernadas, J, Esther Moreno, Gaeta, F, Josefina Rodrigues Cernadas, Ingrid Böhm, Knut Brockow, Scherer, K, Hye‐Ryun Kang, Torres, M J, Annick Barbaud, Gaeta, Francesco, Bonadonna, P, Böhm, Ingrid, Bonadonna, Patrizia, Kang, H, Böhm, I, Ana M. Gimenez‐Arnau, Barbaud, Annick, Axel Trautmann, Trautmann, Axel, Kang, Hye-Ryun, Sevim Bavbek, Kang H, Cernadas J, Bavbek S, Trautmann A, Bonadonna P, Scherer K, Barbaud A, Chiriac A, Böhm I, Moreno E, Gaeta F, Gimenez-Arnau AM, Brockow K, Torres MJ   +58 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Nitazoxanide and nonsteroidal anti-inflammatory drugs (NSAIDs): unveiling the connection in immediate hypersensitivity cross-reactions

Einstein (São Paulo)
Intestinal worm infections, referred to as helminthiases, represent a significant global health challenge, particularly in low- and middle-income countries.
André Luiz Oliveira Feodrippe, Marcelo Vivolo Aun, Elaine Gagete, Jorge Kalil, Pedro Giavina-Bianchi   +4 more
doaj   +1 more source

Chlorhexidine Hypersensitivity: A Case Report of Delayed Reactions Associated with Epidermal Preparations

Plastic and Reconstructive Surgery, Global Open, 2020
Summary:. Chlorhexidine is a topical antiseptic that is generally well tolerated in patients, making it a common preparatory substance in various surgical settings.
Priya Bhardwaj, MS, Jenna C. Bekeny, BA, Elizabeth G. Zolper, BS, Manas Nigam, MD, Sarah R. Sher, MD   +4 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

A Case of Immediate Hypersensitivity Reaction to Maltitol

Case Reports in Medicine, 2017
Background. Maltitol is a sugar alcohol that is frequently used as a noncaloric sweetener, although it is also used as an excipient, a plasticizer in gelatin capsules, and an emollient.
Ana Rodríguez Trabado, Carmen Cámara Hijón, José Antonio García-Trujillo, Irene Magriz Trascón, Luis Miguel Fernández Pereira   +4 more
doaj   +1 more source

Hypersensitivity to Gadolinium-Based Contrast Media

Frontiers in Allergy, 2022
Gadolinium-based contrast agents (GBCAs) are frequently used in magnetic resonance imaging (MRI) examinations to increase sensitivity in diagnoses. Recently, an increase in the description of hypersensitivity reactions to GBCAs has been detected.
M. Teresa Gracia Bara, M. Teresa Gracia Bara, Alicia Gallardo-Higueras, Esther M. Moreno, Esther M. Moreno, Esther M. Moreno, Esther M. Moreno, Elena Laffond, Elena Laffond, Elena Laffond, Francisco J. Muñoz Bellido, Francisco J. Muñoz Bellido, Francisco J. Muñoz Bellido, Cristina Martin, Cristina Martin, Miriam Sobrino, Miriam Sobrino, Eva Macias, Eva Macias, Eva Macias, Sonia Arriba-Méndez, Sonia Arriba-Méndez, Sonia Arriba-Méndez, Rosita Castillo, Ignacio Davila, Ignacio Davila, Ignacio Davila, Ignacio Davila   +27 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source