Results 61 to 70 of about 661,856 (255)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity

World Allergy Organization Journal
Background: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to
So-Young Park, MD, PhD, So Young Park, MD, PhD, Sujin Seo, BS, Hyouk-Soo Kwon, MD, PhD, Seung-Hyun Kim, PhD, Sae-Hoon Kim, MD, PhD, Hye-Kyung Park, MD, PhD, Yoon-Seok Chang, MD, PhD, Cheol-Woo Kim, MD, PhD, Byung Jae Lee, MD, PhD, Hae-Sim Park, MD, PhD, You Sook Cho, MD, PhD, Heung-Bum Oh, PhD, David A. Ostrov, PhD, Sungho Won, PhD, Tae Bum Kim, MD, PhD   +15 more
doaj   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Hypersensitivity reactions to contrast media: Part 1. Management of immediate and non-immediate hypersensitivity reactions in adults. Updated guidelines by the ESUR Contrast Media Safety Committee [PDF]

Hypersensitivity reactions to iodine-based, gadolinium-based and ultrasound contrast agents are a heterogeneous group that occur infrequently and can be classified as either immediate or non-immediate.
van de Ven, Annick A. J. M., Clément, Olivier, Dekkers, Ilona A., Mallio, Carlo A., Stacul, Fulvio, Quattrocchi, Carlo C., van de Ven, Annick A.J.M.; id_orcid, Correas, Jean Michel, Romanini, Laura, Radbruch, Alexander, Vega, Francisco, van der Molen, Aart J., Bellin, Marie-France, Deike, Katerina, Bellin, Marie France, Sebastià, Carmen, Geenen, Remy W.F., Bertolotto, Michele, Correas, Jean-Michel, Roditi, Giles, Heinz, Gertraud, Geenen, Remy W. F., Mahnken, Andreas H., Brismar, Torkel B., Reimer, Peter, Vega, F, van, der Molen AJ, Correas, J-M, Clement, O, Sebasti\ue0, Carmen, Bellin, M-F, Dekkers, IA, Brismar, TB, Cl\ue9ment, Olivier, Geenen, RWF, Bertolotto, M, van, de Ven AAJM   +36 more
core   +1 more source

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Irreversible Electroporation for Inferior Turbinate Reduction Ablation in Adults

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Inferior turbinate hypertrophy is a common cause of nasal airway obstruction. An optimal surgical approach should provide effective volume reduction while preserving mucosal integrity and minimizing postoperative morbidity. Objective To evaluate the safety and efficacy of irreversible electroporation (IRE) for non‐thermal ablation ...
Narin Nard Carmel Neiderman, Codrut Sarafoleanu, Ionut Tanase, Mihai Alexandru Pascu, Desiderio Passali, Ulugbek Saidakramovich Khasanov, Ulugbek Nuridinovich Vokhidov, Eugenijus Lesinskas, Marius Polianskis, Avraham Abergel   +9 more
wiley   +1 more source

Immediate-type hypersensitivity reactions due to antituberculosis drugs: a successful readministration protocol

, 2015
Dursun, A. Berna/0000-0002-6337-6326Background: Little is known about drug hypersensitivity reactions from antituberculosis drugs. Objective: To determine the frequency, risk factors, and characteristics of immediate-type hypersensitivity reactions from ...
Erkekol, Ferda Öner, Buhari, Gözde Köycü, Güler, Müjgan, Dulkar, Güngör, Özkara, Şeref, Keren, Metin, Kalaç, Nilgün, Dursun, Adile Berna, Dursun, AB, Buhari, GK, Dulkar, G, Keren, M, Güler, M, Özkara, Ş, Erkekol, FERDA, Kalaç, N   +15 more
core   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

The Immunology of Immediate and Delayed Hypersensitivity Reaction to Gluten

European Journal of Inflammation, 2008
The immunology of gluten hypersensitivity and celiac disease has been pursued with significant interest in the past 20 years. For the prevention of systemic diseases, most pathogens that gain entry into our bodies must be met with an effective immune ...
A. Vojdani, T. O'Bryan, G.H. Kellermann
doaj   +1 more source

Repository to: Dual intracellular staining of CD154(CD40L) and cytokines at single cell level: a novel aid to document immediate hypersensitivity to amoxicillin

, 2023
Respository methods, tables and figures to "Dual intracellular staining of CD154(CD40L) and cytokines at single cell level: a novel aid to document immediate hypersensitivity to amoxicillin"
Ebo Didier G., Sabato Vito, Mertens Christel, Van Gasse Athina L., van Houdt Michel, van der Poorten Marie-Line M., Hagendorens Margo M., Elst Jessy   +7 more
core   +1 more source