Results 51 to 60 of about 54,107 (304)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Chlorhexidine Hypersensitivity: A Case Report of Delayed Reactions Associated with Epidermal Preparations

Plastic and Reconstructive Surgery, Global Open, 2020
Summary:. Chlorhexidine is a topical antiseptic that is generally well tolerated in patients, making it a common preparatory substance in various surgical settings.
Priya Bhardwaj, MS, Jenna C. Bekeny, BA, Elizabeth G. Zolper, BS, Manas Nigam, MD, Sarah R. Sher, MD   +4 more
doaj   +1 more source

Hypersensitivity to Gadolinium-Based Contrast Media

Frontiers in Allergy, 2022
Gadolinium-based contrast agents (GBCAs) are frequently used in magnetic resonance imaging (MRI) examinations to increase sensitivity in diagnoses. Recently, an increase in the description of hypersensitivity reactions to GBCAs has been detected.
M. Teresa Gracia Bara, M. Teresa Gracia Bara, Alicia Gallardo-Higueras, Esther M. Moreno, Esther M. Moreno, Esther M. Moreno, Esther M. Moreno, Elena Laffond, Elena Laffond, Elena Laffond, Francisco J. Muñoz Bellido, Francisco J. Muñoz Bellido, Francisco J. Muñoz Bellido, Cristina Martin, Cristina Martin, Miriam Sobrino, Miriam Sobrino, Eva Macias, Eva Macias, Eva Macias, Sonia Arriba-Méndez, Sonia Arriba-Méndez, Sonia Arriba-Méndez, Rosita Castillo, Ignacio Davila, Ignacio Davila, Ignacio Davila, Ignacio Davila   +27 more
doaj   +1 more source

Biomarkers of immediate drug hypersensitivity

Allergy, 2023
AbstractImmediate drug hypersensitivity reactions (IDHRs) are a burden for patients and the health systems. This problem increases when taking into account that only a small proportion of patients initially labelled as allergic are finally confirmed after an allergological workup.
Cristobalina Mayorga, Adriana Ariza, Rosa Muñoz‐Cano, Vito Sabato, Inmaculada Doña, Maria J. Torres   +5 more
openaire   +5 more sources

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

The incidence of anaphylaxis in Emergency Room of Songklanagarind Hospital

Journal of Health Science and Medical Research (JHSMR), 2010
Objective: To study the incidence rate of anaphylaxis in the emergency room of Songklanagarind Hospital. Material and Methods: The medical records of patients diagnosed as having anaphylaxis who visited Songklanagarind Hospital's Emergency Room from June
Darm Rungrotkumnerd, Prasit Wuthisuthimethawee, Pasuree Sangsupawanich   +2 more
doaj  

A Case of Immediate Hypersensitivity Reaction to Maltitol

Case Reports in Medicine, 2017
Background. Maltitol is a sugar alcohol that is frequently used as a noncaloric sweetener, although it is also used as an excipient, a plasticizer in gelatin capsules, and an emollient.
Ana Rodríguez Trabado, Carmen Cámara Hijón, José Antonio García-Trujillo, Irene Magriz Trascón, Luis Miguel Fernández Pereira   +4 more
doaj   +1 more source

The Time Delay Between Drug Intake and Bronchospasm for Nonsteroidal Antiinflammatory Drugs Sensitive Patients

World Allergy Organization Journal, 2010
A study was performed to assess the time between drug intake and drug induced hypersensitivity reaction for patients sensitive to nonsteroidal antiinflammatory drugs (NSAID) in clinical patient history and after oral provocation tests.
Giedre Grigiene, MD, Jolita Norkūnienė, PhD, Violeta Kvedariene, MD, PhD   +2 more
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Specific questionnaire detects a high incidence of intra-operative hypersensitivity reactions

Clinics, 2018
OBJECTIVE: To assess the incidence of intra-operative immediate hypersensitivity reactions and anaphylaxis. METHODS: A cross-sectional observational study was conducted at the Department of Anesthesiology, University of São Paulo School of Medicine ...
Laila S. Garro, Marcelo V. Aun, Iracy Sílvia C. Soares, Marisa R. Ribeiro, Antônio A. Motta, Jorge Kalil, Mariana C. Castells, Maria José C. Carmona, Pedro Giavina-Bianchi   +8 more
doaj   +1 more source