Results 71 to 80 of about 54,107 (304)

Skin Tests for Immediate Hypersensitivity

, 2020
Skin testing for immediate hypersensitivity serves as a very useful tool in the diagnostic workup of a suspected allergic patient, but it is mandatory to bear in mind that the tests measure sensitization and not clinical disease.
Gotthard Mørtz, Charlotte; id_orcid, Charlotte Gotthard Mørtz, Bindslev-Jensen, Carsten; id_orcid, Carsten Bindslev-Jensen   +3 more
core   +1 more source

Practice Parameters for Diagnosing and Managing Iodinated Contrast Media Hypersensitivity. [PDF]

, 2020
Immediate and non-immediate hypersensitivity reactions to iodinated contrast media (ICM) have been reported to occur in a frequency of about 0.5-3% of patients receiving non-ionic ICM.
Kathrin Scherer, Torres, María José, Moreno, E, Patrizia Bonadonna, Francesco Gaeta, Moreno, Esther, Trautmann, A, Gimenez-Arnau, A M, Barbaud, A, Chiriac, A, Bavbek, Sevim, Gimenez-Arnau, Ana M, Anca Mirela Chiriac, Kang, Hye‐ryun, María José Torres, Cernadas, Josefina Rodrigues, Brockow, Knut, Brockow, K, Scherer, Kathrin, Rodrigues-Cernadas, Josefina, Gimenez-Arnau, Ana, Chiriac, Anca Mirela, Bavbek, S, Cernadas, J, Esther Moreno, Gaeta, F, Josefina Rodrigues Cernadas, Ingrid Böhm, Knut Brockow, Scherer, K, Hye‐Ryun Kang, Torres, M J, Annick Barbaud, Gaeta, Francesco, Bonadonna, P, Böhm, Ingrid, Bonadonna, Patrizia, Kang, H, Böhm, I, Ana M. Gimenez‐Arnau, Barbaud, Annick, Axel Trautmann, Trautmann, Axel, Kang, Hye-Ryun, Sevim Bavbek   +44 more
core   +1 more source

Female‐Specific Risk of TAS2R Variants in Chronic Rhinosinusitis: A Hospital‐Based Cohort Study From the Taiwan Precision Medicine Initiative

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Bitter taste receptors (T2Rs) function in the innate immune defense of the sinonasal mucosa; however, the genetic association between the TAS2R gene family and chronic rhinosinusitis (CRS) remains understudied in Asian populations.
Rong‐San Jiang, Man‐Wei Hua, I‐Chieh Chen, Yi‐Ming Chen, Shun‐Hung Lin, Kuan‐Yu Lai, Yi‐Chen Chen   +6 more
wiley   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

Drug hypersensitivity reactions involving skin

, 2009
Immune reactions to drugs can cause a variety of diseases involving the skin, liver, kidney, lungs, and other organs. Beside immediate, IgE-mediated reactions of varying degrees (urticaria to anaphylactic shock), many drug hypersensitivity reactions ...
Hausmann, O, Werner J. Pichler, Schnyder, B, Hausmann, Oliver, Oliver Hausmann, Benno Schnyder, Pichler, WJ, Schnyder, Benno, Pichler, Werner J.   +8 more
core   +1 more source

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

The Immunology of Immediate and Delayed Hypersensitivity Reaction to Gluten

European Journal of Inflammation, 2008
The immunology of gluten hypersensitivity and celiac disease has been pursued with significant interest in the past 20 years. For the prevention of systemic diseases, most pathogens that gain entry into our bodies must be met with an effective immune ...
A. Vojdani, T. O'Bryan, G.H. Kellermann
doaj   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

RhoA/ROCK Signaling Pathway Mediates Shuanghuanglian Injection-Induced Pseudo-allergic Reactions

Frontiers in Pharmacology, 2018
Background: Shuanghuanglian injection (SHLI) is a famous Chinese medicine used as an intravenous preparation for the treatment of acute respiratory tract infections.
Jiayin Han, Yong Zhao, Yushi Zhang, Chunying Li, Yan Yi, Chen Pan, Jingzhuo Tian, Yifei Yang, Hongyu Cui, Lianmei Wang, Suyan Liu, Jing Liu, Nuo Deng, Aihua Liang   +13 more
doaj   +1 more source