Results 121 to 130 of about 634,412 (379)
Advanced Science, EarlyView.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Chronic hypersensitivity pneumonitis
Journal of Asthma and Allergy, 2015 Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic.
C. A. Pereira +3 more
semanticscholar +1 more source
Potential mechanism of action of J5 vaccine in protection against severe bovine coliform mastitis. [PDF]
, 2002 Coliform mastitis is one of the most difficult diseases to treat in the modern dairy industry. Curative therapy with antibiotics remains only moderately effective and depends on the stage at which the disease is treated, The most successful strategies ...
Burvenich, Christian +2 more
core +3 more sources
Advanced Science, EarlyView.OsNRT1.1B forms a membrane complex with OsCNGC14/16 that mediates nitrate‐triggered calcium influx. This calcium signal phosphorylates OsNLP3 at Ser193, accelerating its nuclear translocation and activating nitrogen‐responsive genes. The calcium‐dependent pathway complements the established ubiquitination‐mediated pathway, dynamically regulating ...
Xiaohan Wang +9 more
wiley +1 more source
Stress and odor sensitivity in persons with noise sensitivity
Noise and Health, 2013 Previous research has indicated that sensory sensitivity/intolerance to a specific modality may be part of a more general environmental hypersensitivity, and possibly mediated by stress. This study investigated the relationship between noise sensitivity,
Steven Nordin +3 more
doaj +1 more source
Advanced Science, EarlyView.A matrix‐free human liver organoid–T cell co‐culture platform enables modeling of immune‐mediated drug‐induced liver injury (iDILI). Using flucloxacillin and patient‐matched cells, this system recapitulates HLA‐B*57:01–restricted CD8⁺ T cell activation and hepatocyte damage.
Fadoua El Abdellaoui Soussi +11 more
wiley +1 more source
Progesterone hypersensitivity: A challenge for luteal support
Journal of Human Reproductive Sciences, 2018 Progesterone hypersensitivity is a rare phenomenon which can occur after both endogenous and exogenous exposures. We present a case of hypersensitivity to various forms and routes of exogenous progesterone.
Astha Gupta +2 more
doaj +1 more source
Journal of Experimental Medicine, 2015 Weber et al. report that neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity. Their results identify a novel role for neutrophils in shaping the adaptive immune response.
F. C. Weber +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang +19 more
wiley +1 more source
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2021 Background: the correct diagnosis on what the allergens that sensitize the patient are makes it possible to establish an adequate management of the disease, avoiding the contact of patients with these allergens and establishing a more precise ...
Lourdes Leonor Bermudez-Cordoví +3 more
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