Results 121 to 130 of about 648,308 (386)
Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance
Advanced Science, EarlyView.Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar +7 more
wiley +1 more source
Stress and odor sensitivity in persons with noise sensitivity
Noise and Health, 2013 Previous research has indicated that sensory sensitivity/intolerance to a specific modality may be part of a more general environmental hypersensitivity, and possibly mediated by stress. This study investigated the relationship between noise sensitivity,
Steven Nordin +3 more
doaj +1 more source
A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
Advanced Science, EarlyView.Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger +17 more
wiley +1 more source
Progesterone hypersensitivity: A challenge for luteal support
Journal of Human Reproductive Sciences, 2018 Progesterone hypersensitivity is a rare phenomenon which can occur after both endogenous and exogenous exposures. We present a case of hypersensitivity to various forms and routes of exogenous progesterone.
Astha Gupta +2 more
doaj +1 more source
Advanced Science, EarlyView.Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen +8 more
wiley +1 more source
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2021 Background: the correct diagnosis on what the allergens that sensitize the patient are makes it possible to establish an adequate management of the disease, avoiding the contact of patients with these allergens and establishing a more precise ...
Lourdes Leonor Bermudez-Cordoví +3 more
doaj
Establishment of a protocol for preventive vaccination against equine insect bite hypersensitivity
, 2022 Sara Björk Stefánsdóttir +5 more
openalex +1 more source
Probiotics for Prevention of Atopy and Food Hypersensitivity in Early Childhood
Medicine, 2016 Most studies investigated probiotics on food hypersensitivity, not on oral food challenge confirmed food allergy in children. The authors systematically reviewed the literature to investigate whether probiotic supplementation prenatally and/or ...
Guo-Qiang Zhang +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye +12 more
wiley +1 more source