Results 71 to 80 of about 371,617 (308)

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Erythema multiforme: distinguishing hypersensitivity reactions, drug allergy, or herpes simplex infection [PDF]

Exploration of Immunology
Cutaneous reactions present a diagnostic challenge, mainly when multiple factors, such as infections, medications, and environmental triggers, contribute to the clinical picture.
Vesna Vukičević Lazarević
doaj   +1 more source

Modulation of the Bovine Delayed-Type Hypersensitivity Responses to Defined Mycobacterial Antigens by a Synthetic Bacterial Lipopeptide [PDF]

, 2003
The use of defined protein and peptide antigens can overcome specificity limitations of purified protein derivatives in the detection of bovine tuberculosis when the antigens are used in blood-based tests. Since the use of these specific antigens as skin
Howard, CJ, Hewinson, R. G., Vordermeier, H.M., Clifford, D., Hope, Jayne; id_orcid, Whelan, A O   +5 more
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Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project

, 2009
Nonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs.
Kowalski ML, Kowalski, M. L., Zuberbier T, Canonica, G. W., Bousquet, P-J, Burney, P G, Ponvert C, Demoly, P, Salapatas, M., Demoly, P., Aberer, W, Terreehorst, I, Arnoux, B., Martins, P., Gueant, J. L., Sidoroff A, Bonadonna P, Mertes, P-M, Barbaud A, Drug Allergy, Martins, P, Pirmohamed, M, Merk, H F, Ring, J, Szczeklik A, Torres, M. J., Martins P, Gomes, E., Ponvert, C, Daures JP, Bircher A, Blanca, M., Sanz, M. L., Papadopoulos, N., Terreehorst, I., Barbaud, A, Sachs, B., Bijl, A, Gomes E, Aberer W, Dahlen, B, Van Ganse, E, Blanca M, Bijl A, Van Ganse E, Pirmohamed, M., Kvedariene, V, Mertes PM, Papadopoulos, N, Papadopoulos N, Zuberbier, Torsten, Burney, P. G., Fernandez J, the European Network for Drug Allergy, Arnoux B, Barbaud, A., Bonadonna, P, Pirmohamed M, Sachs B, Aberer, W., CANONICA, GIORGIO, Global Allergy, Asthma European Network (GALEN) and Drug Allergy and Hypersensitivity Database (DAHD) and the European Network for Drug Allergy (ENDA), Gueant JL, Bousquet, P. J., Atanaskovic-Markovic, M, Global Allergy Asthma European Network, Fernandez, J., Caimmi S, Bircher, A, Bousquet PJ, Romano, A., Romano, A, Caimmi, S., Mertes, P. M., Bijl, A., Szczeklik, A, Nizankowska Mogilnicka E, Merk, H. F., Gueant, J-L, Sidoroff, A, Ring J, Gomes, E, Pichler, W., Arnoux, B, Atanaskovic Markovic M, Cernadas J, Merk HF, Sachs, Bernhardt, Sidoroff, A., Walter Canonica, G., De Weck, A L, Zuberbier, T, Aberer, Werner, Romano A, Blanca, M, Nizankowska-Mogilnicka, E, Atanaskovic-Markovic, M., Sanz ML, Canonica, G W, Brockow, K., Caimmi, S, Zuberbier, T., Burney PG, Salapatas M, Kowalski, M L, Ponvert, C., Papadopoulos, N.; id_orcid, Dahlen B, Sanz, M L, Sachs, B, Merk, Hans, Szczeklik, A., Brockow, K, De Weck AL, Kvedariene V, Kvedariene, V., Pichler, W, Cernadas, J, Daures, J-P, Bircher, A., Terreehorst I, Torres, M J, Ring, J., Dahlen, B., Daures, J. P., Cernadas, J., Salapatas, M, Fernandez, J, Pichler W, Demoly P, Nizankowska-Mogilnicka, E., Hypersensitivity Database, Bonadonna, P., Brockow K, Torres MJ, van Ganse, E., de Weck, A. L., Pichler, Werner Joseph, Torres, MJ, Bousquet, PJ;Demoly, P;Romano, A;Aberer, W;Bircher, A;Blanca, M;Brockow, K;Pichler, W;Torres, MJ;Terreehorst, I;Arnoux, B;Atanaskovic-Markovic, M;Barbaud, A;Bijl, A;Bonadonna, P;Burney, PG;Caimmi, S;Canonica, GW;Cernadas, J;Dahlén, B;Daurès, JP;Fernandez, J;Gomes, E;Guéant, JL;Kowalski, ML;Kvedariene, V;Mertes, PM;Martins, P;Nizankowska-Mogilnicka, E;Papadopoulos, N;Ponvert, C;Pirmohamed, M;Ring, J;Salapatas, M;Sanz, ML;Szczeklik, A;Van Ganse, E;De Weck, AL;Zuberbier, T;Merk, HF;Sachs, B;Sidoroff, A   +139 more
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Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Peripheral and central mechanisms in acid induced visceral pain hypersensitivity in the human oesophagus [PDF]

, 2010
PhDIntroduction: Gastro-oesophageal reflux disease (GORD) affects 40% of Western populations. Many symptoms persist despite the resolution of inflammation or acid exposure.
Chua, Yang Chong
core   +2 more sources

Chlorhexidine Allergy: Current Challenges and Future Prospects

Journal of Asthma and Allergy, 2020
Chirawat Chiewchalermsri,1,2 Mongkhon Sompornrattanaphan,3 Chamard Wongsa,3 Torpong Thongngarm3 1Division of Allergy and Clinical Immunology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand; 2Department of Medicine, Panyananthaphikkhu
Chiewchalermsri C, Sompornrattanaphan M, Wongsa C, Thongngarm T   +3 more
doaj  

High sensitivity of human leukocyte antigen–B*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients [PDF]

, 2008
Background. Although the human leukocyte antigen (HLA)-B*5701 is highly associated with a hypersensitivity reaction (HSR) to abacavir (ABC), variable sensitivities have been reported when clinical data alone have been used to define an ABC HSR.
Stancil, B., Balu, R., Mosteller, M., Wannamaker, P., Phillips, E.J., Saag, M., Burman, W., Brothers, C., Brachman, P., Hughes, A., Sutherland‐Phillips, D., Martorell, C., Mallal, S., Shaefer, M.   +13 more
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