Results 71 to 80 of about 14,767 (235)

Development of a lower-sodium oxybate formulation for the treatment of patients with narcolepsy and idiopathic hypersomnia

Expert Opinion on Drug Discovery, 2021
Introduction Sodium oxybate (SXB) is a standard of care for cataplexy, excessive daytime sleepiness, and disrupted nighttime sleep in narcolepsy. At recommended dosages in adults (6–9 g/night), SXB increases daily dietary intake of sodium by 1100–1640 mg.
G. Junnarkar, Clark P. Allphin, J. Profant, T. Steininger, Cuiping Chen, K. Zomorodi, R. Skowronski, J. Black   +7 more
semanticscholar   +1 more source

New insights and potential clinical implications of the odds ratio product

Frontiers in Neurology, 2023
The odds ratio product (ORP) is a continuous metric of sleep depth that ranges from 0 (very deep sleep) to 2. 5 (full wakefulness). Its advantage over the conventional method recommended by AASM is that it discloses different levels of stage wake (sleep ...
Magdy Younes
doaj   +1 more source

Sleep Disorders in Klinefelter Syndrome and Other Sex Chromosome Aneuploidies: A Narrative Review

Andrology, EarlyView.
ABSTRACT Background Sex chromosome aneuploidies (SCAs) are among the most frequent types of chromosomal aneuploidies and include Klinefelter syndrome (47,XXY and higher‐grade variants), 47,XYY syndrome, Turner syndrome (45,X), and trisomy X (47,XXX).
Roberto Paparella, Fabiola Panvino, Ida Pucarelli, Luigi Tarani   +3 more
wiley   +1 more source

Residual hypersomnia in unipolar and bipolar depression: A systematic review

World Journal of Biological Psychiatry
Objectives The primary objective in managing depression is achieving full recovery, but some patients experience ongoing symptoms that affect daily life, with residual hypersomnia being notably prevalent.
Julia Kwaśna, A. Kwaśny, A. Wilkowska, Mateusz Bychowski, W. Cubała   +4 more
semanticscholar   +1 more source

‘We're not going to start lifting stones now…’: Stakeholder perspectives on the role of psychometric methods in outcome measurement

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives Psychological outcome measures guide research and clinical decision‐making, yet many widely used tools were developed with limited psychometric rigour. Although advanced methods (e.g., item response theory, structural equation modelling) are now widely available, their added value in applied research remains uncertain and applied ...
David Byrne, Fiona Boland, Susan Brannick, Robert M. Carney, Pim Cuijpers, Alexandra L. Dima, Kenneth E. Freedland, Suzanne Guerin, David Hevey, Bishember Kathuria, Emma Wallace, Frank Doyle   +11 more
wiley   +1 more source

The Hypersomnia Severity Index: reliability, construct, and criterion validity in a clinical sample of patients with sleep disorders

Journal of Clinical Sleep Medicine (JCSM), 2021
The Hypersomnia Severity Index (HSI) was designed to assess the severity and impairment of hypersomnolence and has been validated in persons with psychiatric disorders.
J. Fernandez-Mendoza, K. Puzino, G. Amatrudo, E. Bourchtein, S. Calhoun, D. Plante, K. Kaplan   +6 more
semanticscholar   +1 more source

Reported history of childhood trauma, mentalizing deficits, and hypersomnia in adulthood: A mediational analysis in a nonclinical sample

Brain and Behavior
Background and objective Existing research has confirmed the link between childhood trauma and poor sleep quality in adulthood. This study focused on the relationship between childhood trauma and hypersomnia specifically, which is understudied ...
Bessat Kalantar‐Hormozi, Shahram Mohammadkhani   +1 more
doaj   +1 more source

Relations among daily symptoms of depression

British Journal of Psychology, EarlyView.
Abstract Research has often treated depression as a unitary construct, relying on severity scores or diagnostic thresholds; however, recent studies emphasize that depression is a heterogeneous disorder characterized by dynamic symptom interactions. We aimed to identify unique relations among depressive symptoms when examined longitudinally.
Meghan E. Quinn, Mary E. Kleinman, John P. Standring, Qimin Liu   +3 more
wiley   +1 more source

Self-reported symptoms and objective measures in idiopathic hypersomnia and hypersomnia associated with psychiatric disorders: a prospective cross-sectional study

Journal of Clinical Sleep Medicine (JCSM), 2021
In some patients, it is difficult to correctly nosologically classify daytime sleepiness. Clinical manifestations may be nonspecific; on the basis of objective measures it is possible to determine the current severity of sleepiness, but they do not ...
J. Bušková, Tomáš Dvořáčková Blanka Novák, E. Miletínová, Radana Králová, J. Košťálová, M. Kliková, K. Veldová   +6 more
semanticscholar   +1 more source

Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis

Frontiers in Psychiatry, 2021
Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course.
Lindsay M. Melhuish Beaupre, Lindsay M. Melhuish Beaupre, Arun K. Tiwari, Arun K. Tiwari, Vanessa F. Gonçalves, Vanessa F. Gonçalves, Vanessa F. Gonçalves, Clement C. Zai, Clement C. Zai, Clement C. Zai, Clement C. Zai, Victoria S. Marshe, Victoria S. Marshe, Cathryn M. Lewis, Cathryn M. Lewis, Nicholas G. Martin, Andrew M. McIntosh, Mark J. Adams, Bernhard T. Baune, Bernhard T. Baune, Bernhard T. Baune, Doug F. Levinson, Dorret I. Boomsma, Brenda W. J. H. Penninx, Gerome Breen, Gerome Breen, Steve Hamilton, Swapnil Awasthi, Stephan Ripke, Stephan Ripke, Stephan Ripke, Stephan Ripke, Lisa Jones, Ian Jones, Enda M. Byrne, Ian B. Hickie, James P. Potash, Jianxin Shi, Myrna M. Weissman, Myrna M. Weissman, Yuri Milaneschi, Stanley I. Shyn, Eco J. C. de Geus, Gonneke Willemsen, Gregory M. Brown, Gregory M. Brown, James L. Kennedy, James L. Kennedy, James L. Kennedy, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium   +49 more
doaj   +1 more source