Results 41 to 50 of about 8,171 (214)

Clinicopathological study of new onset pancytopenia: An experience of largest study from a tertiary care center of western India

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2021
Background: Pancytopenia is characterized by decreased hemoglobin (adult males
Ganesh Pendkur, Paresh Singhal, Venkatesan Somasundaram, S K Raghavendra, Sanjeevan Sharma   +4 more
doaj   +1 more source

Diagnosing Systemic Mastocytosis: State of the Art

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT With the advent of effective multikinase and selective tyrosine kinase inhibitors in systemic mastocytosis, diagnosing this rare disease has been critical to improving patient morbidity and mortality. This state‐of‐the‐art review interprets the international diagnostic criteria, including differences between the WHO 5th edition classification ...
Anton Rets, Tracy I. George
wiley   +1 more source

The Spleen Promotes Liver Sinusoidal Endothelial Cell Angiogenesis by Stimulating the TGFβ/Smad2/3 Pathway Through GDF15

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aims Liver sinusoidal endothelial cells (LSECs) are crucial nonparenchymal cells involved in liver fibrosis progression. Liver fibrosis develops from various chronic liver diseases, with pathological progression associated with the spleen. However, the precise mechanism by which the spleen influences LSECs during fibrosis is not
Xi Deng, Na Huang, Ke Du, Hailong Zhang, Ziwei Du, Yudan Fan, Mengchen Zhu, Pengfei Liu, Yanhua Mu, Zongfang Li   +9 more
wiley   +1 more source

Extrahepatic portal venous obstruction: The effects of early ligation of splenic artery during splenectomy

Journal of Indian Association of Pediatric Surgeons, 2009
Aim: To objectively demonstrate the gain in blood volume and blood components following early ligation of splenic artery during splenectomy and splenorenal shunts in children with extra hepatic portal venous obstruction (EHPVO).
Gazula Suhasini, Pawar D, Seth T, Bal C, Bhatnagar V   +4 more
doaj  

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

SUCCESSFUL CHEMOTHERAPY ADMINISTRATION DESPITE HYPERSPLENISM AND PANCYTOPENIA: A CASE OF METASTATIC RECTAL ADENOCARCINOMA

Hematology, Transfusion and Cell Therapy
Introduction: Cytopenias in oncology patients present a significant barrier to the administration of chemotherapy. Hypersplenism is one of the leading causes of cytopenia.
Adil Uğur Kaan Güngör, Abdurrahman Aykut, Berksoy Sahin, Hatice Asoğlu Rüzgar   +3 more
doaj   +1 more source

Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 1, Page 26-40, January 2026.
ABSTRACT The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the splenic clearance of PtdSer‐positive senescent and altered erythrocytes such as erythrocyte ghosts (eryghosts ...
Claire Auditeau, Aurélie Fricot, Raphaël Gauthier, Abdoulaye Sissoko, Zeynep Cacan, Céline Gounou, Laure Joseph, Sandra Manceau, Slimane Allali, Michael Dussiot, Mickael Marin, Alexis Lavergne, Mariem Khamari, Sophie Moog, Elsa Bianchini, Laetitia Claer, Sandrine Laurance, Valentine Brousse, Sébastien Eymieux, Philippe Roingeard, Pascal Amireault, Thiago Trovati Maciel, Alain Brisson, Pierre Buffet, François Saller, Delphine Borgel, Camille Roussel   +26 more
wiley   +1 more source

Never say never

Journal of Hospital Medicine, EarlyView.
Gurpreet Dhaliwal, Jagmeet Dhingra, Tom Fraser, Leal Herlitz, James Pile   +4 more
wiley   +1 more source

Natural‐History Mapping of Lysosomal Storage Disorders (LSDs): Gaucher Disease as a Model for Precision Care

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Natural‐history datasets have become pivotal for drug development and for shaping clinical‐practice guidelines in rare diseases, yet many lysosomal storage disorders would benefit from deep phenotyping and modern analytic methods. Our objective was to integrate the past decade of genomic, cellular, treatment‐outcome, and regulatory advances ...
Noor Ul Ain, Maya Vaishnaw, Pramod. K. Mistry   +2 more
wiley   +1 more source

The Impact of Heterotopic Spleen Regeneration on Tumor Growth

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
The present study evaluated the effect of spleen regeneration on tumor growth. Balb/c mice were divided into three groups: intact animals; animals that underwent splenectomy; animals that underwent splenectomy followed by autologous subcutaneous transplantation of spleen fragments.
Daria Artemova, Andrey Elchaninov, Anna Soboleva, Irina Arutyunyan, Polina Vishnyakova, Liudmila Gaydeek, Timur Fatkhudinov, Gennady Sukhikh   +7 more
wiley   +1 more source