Results 1 to 10 of about 2,704,025 (289)

Sodium‐Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt‐Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Salt‐sensitive hypertension is highly prevalent and associated with cardiorenal damage. Large clinical trials have demonstrated that SGLT2 (sodium‐glucose cotransporter 2) inhibitors exert hypotensive effect and cardiorenal protective benefits
Yu Zhao, Li Li, Zongshi Lu, Yingru Hu, Hexuan Zhang, Fang Sun, Qiang Li, Chengkang He, Wentao Shu, Lijuan Wang, Tingbing Cao, Zhidan Luo, Zhencheng Yan, Daoyan Liu, Peng Gao, Zhiming Zhu   +15 more
doaj   +1 more source

Asprosin induces vascular endothelial-to-mesenchymal transition in diabetic lower extremity peripheral artery disease

Cardiovascular Diabetology, 2022
Background Altered adipokine secretion in dysfunctional adipose tissue facilitates the development of atherosclerotic diseases including lower extremity peripheral artery disease (PAD).
Mei You, Yushuang Liu, Bowen Wang, Li Li, Hexuan Zhang, Hongbo He, Qing Zhou, Tingbing Cao, Lijuan Wang, Zhigang Zhao, Zhiming Zhu, Peng Gao, Zhencheng Yan   +12 more
doaj   +1 more source

Poor sleep quality is negatively associated with low cognitive performance in general population independent of self-reported sleep disordered breathing

BMC Public Health, 2022
Background Sleep disordered breathing (SDB) plays a significant role in both sleep quality and cognition and whether it has an impact on the relationship between above two factors remains to be clear.
Zhongrong Wang, Mulalibieke Heizhati, Lin Wang, Mei Li, Zhikang Yang, Mengyue Lin, Reyila Abudereyimu, Jing Hong, Wenbo Yang, Ling Yao, Shasha Liu, Junli Hu, Nanfang Li   +12 more
doaj   +1 more source

Korea hypertension fact sheet 2018

Clinical Hypertension, 2018
Background The Korea Hypertension Fact Sheet 2018 aims to overview the magnitude and management status of hypertension, and their trends in Korea. Methods The Hypertension Epidemiology Research Group analyzed the 1998–2016 Korea National Health and ...
The Korean Society Hypertension (KSH), Hypertension Epidemiology Research Working Group, Hyeon Chang Kim, Myeong-Chan Cho   +3 more
doaj   +1 more source

Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]

, 2017
Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC, Bina Joe, Biron P, Biron P, Bright R, Cook HW, Dublin LI, Dublin LI, Dupont J, Esunge PM, Felts JH, Garrod AE, Garrod AE, Garrod AE, Hamilton M, Hamilton M, Hamilton M, Joe B, Koffler M, Korner PI, Kuijpers MH, Lee YH, Lewis O, Markel’ AL, Matsukawa N, Mo R, Ohno Y, Pickering GW, Pravenec M, Sandosh Padmanabhan, Schlager G, Shear CL, Shiozawa M, Smolarek I, Zhang Y   +34 more
core   +1 more source

Clinical Characteristics of Target Organ Damage in Primary Aldosteronism with or without Metabolic Syndrome

Journal of Diabetes Research, 2022
The aim of this study is to investigate the prevalence of metabolic disorders in patients with primary aldosteronism (PA) and target organ damage (TOD) in different subtypes of patients with PA with or without metabolic syndrome (MS).
Xiaona Bu, Fang Sun, Hexuan Zhang, Xiaoli Liu, Zhigang Zhao, Hongbo He, Yingsha Li, Zhencheng Yan, Zhiming Zhu   +8 more
doaj   +1 more source

Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]

, 2018
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J., Petrie, John R., Touyz, Rhian M.   +2 more
core   +1 more source

Urinary Podocyte Excretion Predicts Urinary Protein Selectivity and Renal Prognosis

International Journal of Nephrology, 2022
Background. Urinary podocyte excretion is related to a reduction in glomerular podocyte numbers, glomerulosclerosis, and urinary protein selectivity.
Makoto Abe, Akiko Kaiga, Takehiro Ohira, Toshihiko Ishimitsu, Akihiro Tojo   +4 more
doaj   +1 more source

The Childhood Role in Development of Primary Hypertension. [PDF]

, 2018
Primary hypertension is not just an adult disorder. Current US population data on children and adolescents demonstrate a prevalence of elevated blood pressure (BP) and hypertension combined of over 10%.
Falkner, Bonita
core   +2 more sources

Glucocorticoids for treating paediatric pulmonary hypertension: A novel use for a common medication [PDF]

, 2017
Laboratory investigations have shown the role of inflammation in the pathogenesis of pulmonary hypertension and improvement after anti-inflammatory drugs.
Aggarwal, Manish, Grady, Ronald M
core   +2 more sources