Results 151 to 160 of about 2,757,661 (328)

ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice

Scientific Reports
Diabetic kidney disease (DKD) is a major disease characterized by early albuminuria and heightened risk of renal deterioration. Increased reactive oxygen species (ROS) production, especially in glomeruli, plays an important role in the progression of DKD.
Eriko Kajimoto, Hajime Nagasu, Masanobu Takasu, Seiji Kishi, Masafumi Wada, Rie Tatsugawa, Akira Hirano, Tsukasa Iwakura, Reina Umeno, Yoshihisa Wada, Seiji Itano, Hiroyuki Kadoya, Kengo Kidokoro, Tamaki Sasaki, Naoki Kashihara   +14 more
doaj   +1 more source

Renovascular hypertension

Current Opinion in Nephrology and Hypertension, 1993
Renovascular disease, particularly when associated with atherosclerosis, is a common cofactor in accelerating hypertension and deteriorating renal function. With increased longevity and effective antihypertensive medications, the prevalence of vascular lesions affecting renal viability is increasing, possibly accounting for 15% of end-stage renal ...
openaire   +4 more sources

Perceptions About Asymptomatic Hyperuricemia and Views About Urate‐Lowering Therapy in People With Asymptomatic Hyperuricemia

Arthritis Care &Research, EarlyView.
Objective Asymptomatic hyperuricemia is a precursor of gout and is also associated with cardiovascular disease and chronic kidney disease. The aim of this study was to understand perceptions about asymptomatic hyperuricemia and views about urate‐lowering therapy in people with asymptomatic hyperuricemia. Methods Participants in a multinational study of
Nicola Dalbeth, Sarah Stewart, Gregory D. Gamble, Borislav Mihov, Lisa K. Stamp, Janine Haslett, William J. Taylor, Tony R. Merriman, Adwoa Dansoa Tabi‐Amponsah, Anne Horne, Tuhina Neogi, Tristan Pascart, Mariano Andrés, Maria‐Luisa Peral‐Garrido, Eleonora Norkuviene, Janitzia Vazquez‐Mellado, Till Uhlig, Mingshu Sun, Changgui Li, Keith J. Petrie   +19 more
wiley   +1 more source

High salt intake and its dual impact on obesity and cardiovascular mortality in individuals over 50: a paradoxical relationship

BMC Public Health
Background There is still debatable of the optimal standards for obesity and salt intake, particularly their potential impacts on mortality among older population. This study aimed to characterized the complex relationships among high-salt diet, obesity,
Yushuang Luo, Xiaona Bu, Xiaoxiao Liu, Yao Meng, Bing Xue, Xiaona Sun, Xinyi Li, Zhiming Zhu, Kaifa Wang, Qiang Li   +9 more
doaj   +1 more source

Mortality and Macrovascular Risk in Elderly With Hypertension and Diabetes: Effect of Intensive Drug Therapy [PDF]

, 2017
Arseniy Yashkin, Julia Kravchenko, Anatoliy I. Yashin, Frank A. Sloan   +3 more
openalex   +1 more source

Exploring Patients’ Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial

Arthritis Care &Research, EarlyView.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart, Laurène Norberciak, Pascal Richette, Pierre Robinet, Aurore Pacaud, Gauthier Marchasson, Thibault Rabin, Hélène Luraschi, Pierre Maciejasz, Anne‐France Georgel, Augustin Latourte, Hang‐Korng Ea, Sébastien Ottaviani, Charlotte Jauffret, Vincent Ducoulombier   +14 more
wiley   +1 more source

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

Arthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Improving Patient Understanding of Glomerular Disease Terms With ChatGPT

International Journal of Clinical Practice
Conclusion: While GPT-4 effectively simplified information about glomerular diseases, it compromised its accuracy in the process. To implement these findings, we suggest pilot studies in clinical settings to assess patient understanding, using feedback ...
Yasir H. Abdelgadir, Charat Thongprayoon, Iasmina M. Craici, Wisit Cheungpasitporn, Jing Miao   +4 more
doaj   +1 more source

Post-transplantation nephroptosis causing recurrent episodes of acute renal failure and hypertension secondary to intermittent vascular torsion of intraperitoneal renal allograft [PDF]

, 2017
Austin R. Dosch, Madeleine V. Pahl, Uttam Reddy, Clarence E. Foster, Hirohito Ichii   +4 more
openalex   +1 more source

Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease

Arthritis Care &Research, EarlyView.
Objective Antinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non‐AI conditions is associated with disease.
Matthew Chung, John P. Shelley, Gul Karakoc, John Still, Xiaodi Ruan, Jonathan Mosley, C. Michael Stein, Vivian K. Kawai   +7 more
wiley   +1 more source