Results 171 to 180 of about 1,745,719 (302)

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Differences in life expectancy with and without disease using reported, measured, and combined estimates for hypertension and diabetes among older adults in Colombia. [PDF]

PLoS One
Osuna M, Ruvalcaba L, Crimmins E, Cano C, Ailshire J.   +4 more
europepmc   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

MicroRNA-155 at the crossroads of inflammation and vascular dysfunction in essential hypertension. [PDF]

Mol Biol Rep
Salamt N, Che Roos NA, Mohamed Shakrin NNS, Ugusman A.   +3 more
europepmc   +1 more source

pharmacotherapy of Hypertension: conventional and modern treatment

High blood pressure, known as hypertension, poses a concern for health. It affects several adults globally contributing to cardiovascular issues.The rising prevalence of hypertension in lower- and middle-income countries adds pressure to healthcare ...
Uzuegbunam, Odinaka
core  

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Hypertension associated with systemic therapy for hepatocellular carcinoma and management strategies. [PDF]

Front Pharmacol
Li Y, Wang B, Zhang D, Xin Y, Wang X.
europepmc   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Hypertension With High-Risk Features in Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized Clinical Trial.

JAMA Neurol
Ridha M, Hailat R, Stanton R, Merkler AE, Elkind MSV, Longstreth WT, Tirschwell DL, Kronmal RA, Hannawi Y, Kamel H, Burke J, Woo D.   +11 more
europepmc   +1 more source

Co-developing a community health worker-led hypertension control intervention in Peru through a human-centered design approach. [PDF]

Rev Panam Salud Publica
Williams KN, Campos-Blanco K, Underhill LJ, Tenorio-Much J, de Las Fuentes L, Cordova-Ascona L, Vela-Clavo Z, Cuentas-Canal GM, Mendoza-Velasquez JC, Hurtado R, Geng EH, Checkley W, Gittelsohn J, Davila-Roman VG, Beres LK, Hartinger SM.   +15 more
europepmc   +1 more source