Results 221 to 230 of about 2,704,025 (289)

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

Advanced Science, EarlyView.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng, Jianguo Xu, Youjian Hong, Fei Fang, Yan Li, Duo Ci, Bowen Wang   +6 more
wiley   +1 more source

Author Correction: Association of the trajectory of plasma aldosterone concentration with the risk of cardiovascular disease in patients with hypertension: a cohort study

Scientific Reports
Xintian Cai, Shuaiwei Song, Junli Hu, Qing Zhu, Di Shen, Wenbo Yang, Huimin Ma, Qin Luo, Jing Hong, Delian Zhang, Nanfang Li   +10 more
doaj   +1 more source

Prevalence of cardiometabolic diseases in Sub-Saharan Africa: a systematic review and meta-analysis. [PDF]

Glob Health Action
Cassambai S, Tetteh J, Highton P, Kunutsor SK, Darko DO, Jeffers S, Ikhile D, Agot GN, Olenja J, Njoroge PK, Jessen N, Abdala R, Senior L, Amoakoh-Coleman MA, Khunti K, Godia PM, Yawson AE, Lamptey R, Buabeng KO, Damasceno A, Seidu S.   +20 more
europepmc   +1 more source

The Role of Exenatide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, in Idiopathic Intracranial Hypertension and Polycystic Ovary Syndrome: A Case Report [PDF]

Despina Nicolaou, Nicolas Nicolaou, L.N. Douglas, Soteroula Christou   +3 more
openalex   +1 more source

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

Advanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng, Ruijie Xie, Bernd Holleczek, Hermann Brenner, Ben Schöttker   +4 more
wiley   +1 more source

MANAGEMENT OF HYPERTENSION [PDF]

Malaysian Family Physician, 2011
WORKING GROUP CPG MANAGEMENT OF HYPERTENSION MOH MALAYSIA
doaj  

Exploring sex differences and associated risk factors of hypertension among the Bhil tribe of rajasthan, India. [PDF]

BMC Public Health
Kalam MA, Pal S.
europepmc   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

The impact of glycated hemoglobin trajectories on hypertension risk: a retrospective cohort study. [PDF]

Front Nutr
Sun Y, Shen Y, Liu A, Zhao C, Ji X, Li X, Zou Z, Li Z, Wu X, Wang Y, Liu M, Li Y, Hao Y.   +12 more
europepmc   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source