Results 221 to 230 of about 99,604 (303)

Zn2+‐Driven Self‐Amplifying Nanoplatform Enables Cascade Photothermal–Gene Therapy via Mitochondrial Disruption

open access: yesVIEW, EarlyView.
A Zn2+‐activated nanoplatform enables self‐amplifying photothermal–gene therapy by disrupting mitochondria and releasing siRNA, creating a feedback loop that sensitizes tumor cells and enhances ablation in vitro and in vivo. This metal ion‐driven strategy offers a new approach for cascade‐amplified nanotherapeutics. ABSTRACT The therapeutic efficacy of
Zhi Li   +8 more
wiley   +1 more source

Local Low‐Frequency Vibration Enhances Wound‐Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Hard‐to‐heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence‐associated mechanisms, including stress‐responsive p53/p21 signaling and senescence‐associated secretory phenotype‐related inflammation, contribute to impaired wound ...
Daijiro Haba   +6 more
wiley   +1 more source

Temporal Responses to Warming: Do Wild Herbivores Trade Off Heat, Predators, and Humans?

open access: yesIntegrative Zoology, EarlyView.
We untangled how summer temperature, predators, and humans influenced behavioral responses in two deer species. Both reduced their daily activity level in response to warming, yet only roe deer increased nocturnality to avoid heat. Conversely, fallow deer traded off heat avoidance with predator avoidance.
Noemi Pallari   +6 more
wiley   +1 more source

Methylenedioxymethamphetamine (MDMA)‐related fatal poisoning in Australia, 2016 to 2025: Trends, characteristics and toxicology

open access: yesAddiction, EarlyView.
Abstract Aims To determine: (1) Population rates of fatal methylenedioxymethamphetamine (MDMA)‐related poisoning over the period 2016–2023, years with high closure rates in the National Coronial Information System (NDIS); (2) the case characteristics of known cases of fatal MDMA‐related poisoning, 2016–2025; and (3) whether there have been changes in ...
Shane Darke   +5 more
wiley   +1 more source

Experimental Extracorporeal Circulation System: A Pilot Study in Rats

open access: yesArtificial Organs, EarlyView.
A miniature extracorporeal circulation (ECC) system was developed for reproducible rodent studies. This system incorporates an integrated heat exchanger and a silicone membrane oxygenator within a double‐lumen circuit, resulting in an ultralow priming volume of < 1.5 mL.
Akira T. Kawaguchi   +7 more
wiley   +1 more source

Effects of Immediate Skin‐to‐Skin Contact in Preterm Infants in High‐Resource Settings: A Systematic Review

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim A landmark trial published in 2021 demonstrated a 25% reduction in neonatal mortality when comparing immediate skin‐to‐skin contact (iSSC) to conventional care in infants with birthweight 1–1.8 kg in low‐ and middle‐resource settings.
Victoria Rettedal   +7 more
wiley   +1 more source

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