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Rare Duplication in the <i>RYR1</i> Gene Causing Malignant Hyperthermia and Clinical Variability. [PDF]
Genes (Basel)Souza BW +11 more
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Trauma and Hyperthermia. [PDF]
J Educ Teach Emerg MedWebster W, Beaird D, Herman LL.
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Archives of Ophthalmology, 1983
Malignant hyperthermia, a rapidly progressive, frequently lethal syndrome was not described until quite recently. Although treatment with the drug dantrolene has changed its face, a clear understanding and deep respect for the syndrome are necessary to keep fatalities and tragic sequelae to a minimum.
T J, Blanck, R P, Gruener
+7 more sources
Malignant hyperthermia, a rapidly progressive, frequently lethal syndrome was not described until quite recently. Although treatment with the drug dantrolene has changed its face, a clear understanding and deep respect for the syndrome are necessary to keep fatalities and tragic sequelae to a minimum.
T J, Blanck, R P, Gruener
+7 more sources
ASA Refresher Courses in Anesthesiology, 1980
In MH, skeletal muscle acutely and unexpectedly increases its oxygen consumption and lactate production, resulting in greater heat production, respiratory and metabolic acidosis, muscle ridigity, sympathetic stimulation, and increased cellular permeability.
Gerald A. Gronert, Bryan E. Marshall
openaire +4 more sources
In MH, skeletal muscle acutely and unexpectedly increases its oxygen consumption and lactate production, resulting in greater heat production, respiratory and metabolic acidosis, muscle ridigity, sympathetic stimulation, and increased cellular permeability.
Gerald A. Gronert, Bryan E. Marshall
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Science, 1992
In humans genetically predisposed to malignant hyperthermia, anesthesia can induce skeletal muscle rigidity, hypermetabolism, and high fever, which, if not immediately reversed, can lead to tissue damage or death. The corresponding condition in swine leads to stress-induced deaths and devalued meat products. Abnormalities in the Ca
D H, MacLennan, M S, Phillips
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In humans genetically predisposed to malignant hyperthermia, anesthesia can induce skeletal muscle rigidity, hypermetabolism, and high fever, which, if not immediately reversed, can lead to tissue damage or death. The corresponding condition in swine leads to stress-induced deaths and devalued meat products. Abnormalities in the Ca
D H, MacLennan, M S, Phillips
openaire +4 more sources
Journal of Craniofacial Surgery, 2003
Malignant Hyperthermia (MH) has been a recognized complication of general anesthesia after the first case reports in the 1940's. Since then a great deal has been discovered about the genetics, pathophysiology and treatment of this once fatal syndrome. MH is the only clinical entity specifically related to and caused by anesthetic agents.
Syed Z, Ali +2 more
+7 more sources
Malignant Hyperthermia (MH) has been a recognized complication of general anesthesia after the first case reports in the 1940's. Since then a great deal has been discovered about the genetics, pathophysiology and treatment of this once fatal syndrome. MH is the only clinical entity specifically related to and caused by anesthetic agents.
Syed Z, Ali +2 more
+7 more sources
Pediatric Clinics of North America, 1994
Major advances have occurred in the management of MH since this disorder was first described. Despite the initially high mortality, deaths secondary to MH have dramatically decreased over the past 15 years, which is due in large part to the discovery of efficacious therapy.
S J, Kaus, M A, Rockoff
openaire +2 more sources
Major advances have occurred in the management of MH since this disorder was first described. Despite the initially high mortality, deaths secondary to MH have dramatically decreased over the past 15 years, which is due in large part to the discovery of efficacious therapy.
S J, Kaus, M A, Rockoff
openaire +2 more sources
American Journal of Critical Care, 1997
Malignant hyperthermia is a pharmacogenetic disease of skeletal muscle characterized by hypermetabolism that occurs on exposure to a triggering agent or agents. The most common agents are halogenated inhalational anesthetics and succinylcholine, a depolarizing muscle relaxant.
A D, Miranda +3 more
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Malignant hyperthermia is a pharmacogenetic disease of skeletal muscle characterized by hypermetabolism that occurs on exposure to a triggering agent or agents. The most common agents are halogenated inhalational anesthetics and succinylcholine, a depolarizing muscle relaxant.
A D, Miranda +3 more
openaire +4 more sources
Nursing Standard, 2006
Malignant hyperthermia, also known as malignant hyperpyrexia, is a pharmacogenetic condition which can develop during general anaesthesia and can be fatal. The author suggests that more awareness of the condition is needed by ward-based nurses who are involved with patients undergoing surgery.
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Malignant hyperthermia, also known as malignant hyperpyrexia, is a pharmacogenetic condition which can develop during general anaesthesia and can be fatal. The author suggests that more awareness of the condition is needed by ward-based nurses who are involved with patients undergoing surgery.
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Annals of Emergency Medicine, 1987
Malignant hyperthermia is a hereditary trait characterized by hypercatabolic reactions induced by anesthetic drugs, or physical or emotional stress. Patients must be treated quickly and efficiently in order to prevent irreversible organ damage and death.
J L, Tomarken, B A, Britt
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Malignant hyperthermia is a hereditary trait characterized by hypercatabolic reactions induced by anesthetic drugs, or physical or emotional stress. Patients must be treated quickly and efficiently in order to prevent irreversible organ damage and death.
J L, Tomarken, B A, Britt
openaire +2 more sources