Results 101 to 110 of about 40,726 (247)

Extracellular fluid viscosity influences the mechanics and migration of MDA‐MB‐231 cells in a macromolecule‐dependent manner

The FEBS Journal, EarlyView.
Macromolecule‐dependent increases in extracellular fluid viscosity alter cell phenotype. These distinct macromolecules create different extracellular environments that modulate cell morphology and mechanoprotein expression, migration and invasion capacity, and cellular mechanical properties.
Ian M. Smith, Nikka Givpoor, Chenchen Handler, Ariel Abraham, Shohini Banerjee, Giuliano Scarcelli, Kimberly M. Stroka   +6 more
wiley   +1 more source

Carbocisteine Reduces Airway Mucus Obstruction and Alters Inflammatory Cell Populations in a Model of Muco‐Obstructive Lung Disease

Immunology &Cell Biology, EarlyView.
Mice with a muco‐obstructive lung disease phenotype were treated with the mucoactive drug, carbocisteine, which resulted in reduced airway mucus and an alteration in the lung mononuclear cell population which was either as a direct effect of, or secondary to, improved mucus clearance.
Peter Ferris, Ryan Brown, Michael McKelvey, Daniel F. McAuley, Marcus A. Mall, Bronwen Connolly, Clifford C. Taggart   +6 more
wiley   +1 more source

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao, Xiaohui Zhang, Peng Lu, Qiang Wang   +3 more
wiley   +1 more source

Clinical use of sodium bicarbonate in small animals: indications, electrolyte changes and survival outcome

Journal of Small Animal Practice, EarlyView.
Objectives The objective of the study was to describe the use of sodium bicarbonate in dogs and cats. Materials and Methods Retrospective descriptive study of animals administered sodium bicarbonate from 2019 to 2023 in a university teaching hospital.
L. Hoover, M. A. Oyama, E. L. Reineke
wiley   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Evaluation of the in vitro quality of X‐ray irradiated red cell concentrates processed and stored using di(2‐ethylhexyl) terephthalate plasticized blood bag sets

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Polyvinyl chloride (PVC) blood bags plasticized with di(2‐ethylhexyl) phthalate (DEHP) have long been the standard for red blood cell (RBC) storage. Due to safety concerns, alternatives like di(2‐ethylhexyl) terephthalate (DEHT), in combination with next‐generation additive solutions like phosphate‐adenine‐glucose ...
Carly Olafson, Sanaz Hemmatibardehshahi, Geraldine M. Walsh, Anita Howell   +3 more
wiley   +1 more source

An exploratory evaluation of the frequency of perioperative changes in electrolyte, acid–base, creatinine, glucose, and lactate variables in dogs and cats undergoing cranial surgery for tumor resection

Veterinary Surgery, EarlyView.
Abstract Objective To explore the frequency and severity of abnormalities in perioperative point‐of‐care bloodwork in dogs and cats undergoing cranial surgery for tumor resection with particular emphasis on dyskalemia development. Study design Retrospective observational study. Animals A total of 61 dogs and 14 cats undergoing cranial surgery for tumor
Zoe E. Weiss, Vishal D. Murthy, Steven E. Epstein, Kate Hopper, Sabrina N. Hoehne   +4 more
wiley   +1 more source

Evaluation of Additional Treatment for Residual Cases After Endoscopic Papillectomy of Duodenal Ampullary Tumors

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Background and Aims This study aimed to assess the prognosis and outcomes of additional treatment for residual adenocarcinoma and adenoma following endoscopic papillectomy (EP) for ampullary tumors. Methods Of 191 patients who underwent EP, 43 with adenocarcinoma or adenoma and either positive or unknown pathological margins were included ...
Yusuke Kurita, Keiki Nagai, Noriki Kasuga, Kensuke Kubota, Yuji Fujita, Yusuke Sekino, Hiroki Uechi, Yuji Koyama, Shintaro Tsujikawa, Shota Matsumoto, Shigeki Tamura, Yu Honda, Shin Yagi, Takeshi Iizuka, Sho Hasegawa, Takamitsu Sato, Kunihiro Hosono, Noritoshi Kobayashi, Yuki Honma, Ryusei Matsuyama, Jotaro Harada, Masato Yoneda, Satoshi Fujii, Itaru Endo, Atsushi Nakajima   +24 more
wiley   +1 more source

Post‐Endoscopic Retrograde Cholangiopancreatography Bleeding After Endoscopic Stone Removal in Dialysis Patients: A Multicenter Retrospective Study

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives Post‐endoscopic retrograde cholangiopancreatography (post‐ERCP) bleeding occurs more frequently in dialysis patients than in non‐dialysis patients. This study aimed to identify risk factors for post‐ERCP bleeding following stone removal in patients undergoing dialysis.
Masaki Nishimura, Haruo Miwa, Takashi Kaneko, Kazuki Endo, Ritsuko Oishi, Yuichi Suzuki, Hiromi Tsuchiya, Yoshimasa Suzuki, Yoshihiro Goda, Akihiro Funaoka, Nobutaka Doba, Kuniyasu Irie, Yuki Miura, Tomohiro Ishii, Masaaki Kondo, Kazuya Sugimori, Shin Maeda   +16 more
wiley   +1 more source

Bronchiectasis as an Underrecognized Extraintestinal Manifestation of Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Introduction Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract, often presenting with extraintestinal manifestations (EIMs). The most prevalent pulmonary EIM is IBD‐associated bronchiectasis (IBD‐BE), which is often overlooked.
Lynn te Slaa, Josje Altenburg, Mark Löwenberg   +2 more
wiley   +1 more source