Results 1 to 10 of about 27,182 (181)

Hypertonic Saline or Carbocisteine in Bronchiectasis [PDF]

New England Journal of Medicine
Bronchiectasis guidelines are inconsistent with regard to the effectiveness of mucoactive agents, and their use varies geographically. Large trials are needed to assess safety and effectiveness.For this open-label, randomized, two-by-two factorial trial at 20 sites in the United Kingdom, we enrolled participants with non-cystic fibrosis bronchiectasis ...
Judy M. Bradley, Brenda O’Neill, Daniel F. McAuley, James D. Chalmers, Anthony De Soyza, Adam T. Hill, Mary Carroll, Michael R. Loebinger, Jamie Duckers, Mike Clarke, Rebecca H. McLeese, Kathryn Ferguson, Andrew Jackson, Christina Campbell, Clíona McDowell, Ashley Agus, John Norrie, Fiona Copeland, Damian G. Downey, Rory Convery, Martin Kelly, William Flight, Nick P. Talbot, John R. Hurst, John Steer, Muhammad Anwar, Mitra Shahidi, Timothy Gatheral, Mohamed Etumi, Anita L. Sullivan, Andreea Alina Ionescu, Veeresh Patil, Milan Bhattacharya, Steven Caskey, Denise Cosgrove, Conor Hagan, Amelia Shoemark, Terence McManus, Gareth Davies, J. Stuart Elborn   +39 more
core   +9 more sources

Hypertonic Saline [PDF]

Journal of the Royal Army Medical Corps, 2004
The optimal fluid for the resuscitation of critically ill and injured patients remains the subject of considerable controversy. Hypertonic crystalloid solutions such as hypertonic saline provide rapid volume expansion, have an acceptable safety profile, and are easy to store and transport.
J E, Smith, M J, Hall
openaire   +2 more sources

Painless intrathecal hypertonic saline [PDF]

Canadian Anaesthetists’ Society Journal, 1974
Hypertonic saline, when injected into the lumbar subarachnoid space for the relief of intractable pain, causes pain, unpleasant muscle cramps and potentially dangerous sympathetic discharge. These side effects can be avoided by adding a weak concentration of local anaesthetic to the brine solution.
A W, Squire, O, Calvillo, P R, Bromage
openaire   +2 more sources

Mechanisms and applications of hypertonic saline [PDF]

Journal of the Royal Society of Medicine, 2011
Hypertonic saline is a strong sterile solution of salt water that can be inhaled as a nebulized medication for people with cystic fibrosis (CF). To examine how it should be applied clinically, it is worth considering the mechanisms by which it affects the disease process, and which signs, symptoms and other clinical outcomes it influences.
Mark R, Elkins, Peter T P, Bye
openaire   +2 more sources

Hypertonic Saline for Hyponatremia [PDF]

Clinical Journal of the American Society of Nephrology, 2007
Data regarding dosage-response relationships for using hypertonic saline in treatment of hyponatremia are extremely limited. Objectives of this study were to assess adherence to previously published guidelines (limiting correction to 18 mEq/L per 48 h. No patient's rate was corrected by >25 mEq/L per 48 h. Among patients with serum sodium
Hashim K, Mohmand, Dany, Issa, Zubair, Ahmad, Joseph D, Cappuccio, Ruth W, Kouides, Richard H, Sterns   +5 more
openaire   +2 more sources

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

Advanced NanoBiomed Research, EarlyView.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen, Michael B. Nguyen, Elliot Widd, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Houston Harding, Chloe Hurteau, Anika Yogi, Colin Luo, Rebecca L. Braden, Pedro Cabrales, Karen L. Christman   +14 more
wiley   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source

Admission Plasma Lipopolysaccharide‐binding protein, Procalcitonin, and Lactate for Early Identification of Nosocomial Infection in Cirrhotic Patients With Upper Gastrointestinal Bleeding: A Retrospective Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to assess whether admission plasma lipopolysaccharide‐binding protein (LBP), procalcitonin (PCT), and lactate could improve detection of nosocomial infection in cirrhotic patients presenting with upper gastrointestinal bleeding (UGIB).
Li Chen, Shan‐Shan Dun, Fang Xiao
wiley   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source