Measuring airway surface liquid depth in ex vivo mouse airways by X-ray imaging for the assessment of cystic fibrosis airway therapies [PDF]
, 2013 In the airways of those with cystic fibrosis (CF), the leading pathophysiological hypothesis is that an ion channel defect results in a relative decrease in airway surface liquid (ASL) volume, producing thick and sticky mucus that facilitates the ...
Boucher, R. +10 more
core +11 more sources
Therapeutic effects of compound hypertonic saline on rats with sepsis
Brazilian Journal of Infectious Diseases, 2014 Sepsis is one of the major causes of death and is the biggest obstacle preventing improvement of the success rate in curing critical illnesses. Currently, isotonic solutions are used in fluid resuscitation technique.
Fang Dong +4 more
doaj +1 more source
Hypertonic saline in ICU setting: what is its position? A systematic review and empirical analysis
Ain Shams Journal of Anesthesiology, 2022 Background Fluid overload has been linked to poor outcomes in the critically ill in recent years, with multiple studies showing an increase in mortality in the overall intensive care unit population.
Marco Dornelles +2 more
doaj +1 more source
Characterization of a Human Powered Nebulizer Compressor for Resource Poor Settings [PDF]
, 2014 Background Respiratory disease accounts for three of the ten leading causes of death worldwide. Many of these diseases can be treated and diagnosed using a nebulizer. Nebulizers can also be used to safely and efficiently deliver vaccines.
Hallberg, Christopher J. +4 more
core +2 more sources
Therapeutic Advances in Respiratory Disease, 2012 Background: Hypertonic saline inhalation has been shown to be effective in patients with cystic fibrosis and lung disease. However, adverse events including marked airway narrowing are reported and a bronchodilator must be given before the administration
Maria Lucia Furnari +7 more
doaj +1 more source
RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? [PDF]
, 2016 Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche.
Johnson, Zariel I. +2 more
core +2 more sources
Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis
The Scientific World Journal, 2012 The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance.
Emer P. Reeves +3 more
doaj +1 more source
Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans [PDF]
, 2018 C. elegans is widely used to investigate biological processes related to health and disease. To study protein localization, fluorescently-tagged proteins can be used in vivo or immunohistochemistry can be performed in whole worms.
Mata Cabana, Alejandro +3 more
core +2 more sources
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
The comparison between steroid and hypertonic saline 10% with steroid in transforaminal epidural injection in patients with unilateral foraminal stenosis [PDF]
International Clinical Neuroscience Journal, 2015 Background: Chronic radicular low back pain is a common disease that limits patient’s daily activity. Epidural steroid injection is becoming the mainstay of therapies for radicular low back pain due to contained bulged disc.
Behnam Hosseini +4 more
doaj +1 more source