Results 31 to 40 of about 906 (141)

Hypertonic Saline or Carbocisteine in Bronchiectasis

New England Journal of Medicine
Bronchiectasis guidelines are inconsistent with regard to the effectiveness of mucoactive agents, and their use varies geographically. Large trials are needed to assess safety and effectiveness.For this open-label, randomized, two-by-two factorial trial at 20 sites in the United Kingdom, we enrolled participants with non-cystic fibrosis bronchiectasis ...
Judy M. Bradley, Brenda O’Neill, Daniel F. McAuley, James D. Chalmers, Anthony De Soyza, Adam T. Hill, Mary Carroll, Michael R. Loebinger, Jamie Duckers, Mike Clarke, Rebecca H. McLeese, Kathryn Ferguson, Andrew Jackson, Christina Campbell, Clíona McDowell, Ashley Agus, John Norrie, Fiona Copeland, Damian G. Downey, Rory Convery, Martin Kelly, William Flight, Nick P. Talbot, John R. Hurst, John Steer, Muhammad Anwar, Mitra Shahidi, Timothy Gatheral, Mohamed Etumi, Anita L. Sullivan, Andreea Alina Ionescu, Veeresh Patil, Milan Bhattacharya, Steven Caskey, Denise Cosgrove, Conor Hagan, Amelia Shoemark, Terence McManus, Gareth Davies, J. Stuart Elborn   +39 more
openaire   +3 more sources

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

Advanced NanoBiomed Research, EarlyView.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen, Michael B. Nguyen, Elliot Widd, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Houston Harding, Chloe Hurteau, Anika Yogi, Colin Luo, Rebecca L. Braden, Pedro Cabrales, Karen L. Christman   +14 more
wiley   +1 more source

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source

Mannitol versus hypertonic saline for intra-operative brain relaxation during aneurysm surgery

Journal of Neuroanaesthesiology and Critical Care, 2015
Background: The study was designed to compare the effects of equiosmolar and equivolemic 3% hypertonic saline (HTS) and 20% mannitol (M) on brain relaxation during aneurysm surgery. Materials and Methods: A prospective, randomised, double-blind study was
Shalini Sharma, Vinod K. Grover, Preethy J. Mathew   +2 more
doaj   +1 more source

Mortality From Rural Traumatic Brain Injury Are Underestimated Without Inclusion of Prehospital Deaths

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Rural residents are more likely to suffer moderate and severe traumatic brain injury (TBI) and experience delay to definitive care than urban patients. Prior studies comparing these populations were based on hospitalised patients only. We examined TBI outcomes incorporating pre‐hospital mortality to determine the association between
Gareth Rutter, Maria Joseph, Richard Ferch, Mitchell A. Hansen, Zsolt J. Balogh   +4 more
wiley   +1 more source

Salbutamol Nebulisation in Normal Saline versus Salbutamol Nebulisation in Hypertonic Saline (3%) in Children with Acute Asthma Exacerbation: An Open-labelled Randomised Controlled Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Asthma has a significant impact and is the leading cause of morbidity and mortality in children. Salbutamol has been the cornerstone of treatment for bronchial constriction in asthma.
Mohanlal Kundu, Kapil Bhalla, Dinkar Yadav, Hunny Verma, Neeraj Kumar, Mukesh Saini, Mohit Yadav, Neha Yadav   +7 more
doaj   +1 more source

Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial

BJU International, Volume 135, Issue 4, Page 638-647, April 2025.
Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui, Marlene Elmelund, Niels Klarskov   +2 more
wiley   +1 more source

Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre‐Specified Secondary Analysis of the TVFR Trial

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Hyponatraemia is a common electrolyte disorder often driven by excess arginine vasopressin (AVP). Copeptin is a stable surrogate marker co‐secreted with AVP. It is unclear whether treatment of hyponatraemia with tolvaptan, an AVP‐V2 receptor antagonist, impacts copeptin.
Annabelle M. Warren, Kay Weng Choy, Rudolf Hoermann, Nicholas Russell, Mathis Grossmann   +4 more
wiley   +1 more source

Acute and sudden death secondary to cardiac tamponade during anaesthetic recovery in a 21‐year‐old draught mule

Equine Veterinary Education, EarlyView.
Summary This case report is of educational value and contributes to the literature because it describes a unique death after anaesthesia due to cardiac tamponade from a rare cardiac neoplasm. In trying to diagnose the origin of chronic sinusitis, a geriatric mule mare was anaesthetised and during recovery, died acutely.
A. Carroll, J. Quandt, S. Dantino
wiley   +1 more source