Results 21 to 30 of about 906 (141)

Randomised controlled trials may underestimate drug effects: balanced placebo trial design.

PLoS ONE, 2014
BackgroundIt is an inherent assumption in randomised controlled trials that the drug effect can be estimated by subtracting the response during placebo from the response during active drug treatment.ObjectiveTo test the assumption of additivity.
Karen Lund, Lene Vase, Gitte L Petersen, Troels S Jensen, Nanna B Finnerup   +4 more
doaj   +1 more source

Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats [PDF]

Acta Cirúrgica Brasileira, 2017
Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five
Marcus Vinicius Henriques Brito, Edson Yuzur Yasojima, Sandro Percário, Rubens Fernando Gonçalves Ribeiro Júnior, Lainy Carollyne da Costa Cavalcante, Andrew Moraes Monteiro, Rodrigo Paracampo Couteiro, Ivone Aline da Silva Rodrigues, Hellen Aparecida Geyer dos Santos   +8 more
doaj   +1 more source

Equiosmolar doses of hypertonic saline versus mannitol for brain relaxation in patients undergoing elective craniotomies: an updated systematic review and meta-analysis

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background Hypertonic saline and mannitol are hyperosmolar agents frequently used to lower ICP and relax the brain during surgeries. Several methods have been used to achieve a good and relaxed brain, such as hyperventilation, cerebrospinal fluid ...
Theodorus Kevin Putra Johansyah, Jeremy Jonathan, I. G. A. A. Andra Yusari, John Nolan, Alif Hakim Alamsyah, Geizar Arsika Ramadhana   +5 more
doaj   +1 more source

Hypertonic saline in ICU setting: what is its position? A systematic review and empirical analysis

Ain Shams Journal of Anesthesiology, 2022
Background Fluid overload has been linked to poor outcomes in the critically ill in recent years, with multiple studies showing an increase in mortality in the overall intensive care unit population.
Marco Dornelles, Erik P. Dornelles, Larissa P. Dornelles   +2 more
doaj   +1 more source

Therapeutic effects of compound hypertonic saline on rats with sepsis

Brazilian Journal of Infectious Diseases, 2014
Sepsis is one of the major causes of death and is the biggest obstacle preventing improvement of the success rate in curing critical illnesses. Currently, isotonic solutions are used in fluid resuscitation technique.
Fang Dong, Wei Chen, Liang Xu, Huabing Wang, Huizhi Lu   +4 more
doaj   +1 more source

Nebulized hypertonic saline containing hyaluronic acid improves tolerability in patients with cystic fibrosis and lung disease compared with nebulized hypertonic saline alone: a prospective, randomized, double-blind, controlled study

Therapeutic Advances in Respiratory Disease, 2012
Background: Hypertonic saline inhalation has been shown to be effective in patients with cystic fibrosis and lung disease. However, adverse events including marked airway narrowing are reported and a bronchodilator must be given before the administration
Maria Lucia Furnari, Lisa Termini, Gabriella Traverso, Stefania Barrale, Maria Rita Bonaccorso, Giuseppina Damiani, Caterina Lo Piparo, Mirella Collura   +7 more
doaj   +1 more source

Hypertonic Saline for Hyponatremia [PDF]

Clinical Journal of the American Society of Nephrology, 2007
Data regarding dosage-response relationships for using hypertonic saline in treatment of hyponatremia are extremely limited. Objectives of this study were to assess adherence to previously published guidelines (limiting correction to 18 mEq/L per 48 h. No patient's rate was corrected by >25 mEq/L per 48 h. Among patients with serum sodium
Hashim K, Mohmand, Dany, Issa, Zubair, Ahmad, Joseph D, Cappuccio, Ruth W, Kouides, Richard H, Sterns   +5 more
openaire   +2 more sources

Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis

The Scientific World Journal, 2012
The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance.
Emer P. Reeves, Kevin Molloy, Kerstin Pohl, Noel G. McElvaney   +3 more
doaj   +1 more source

Sodium Alginate‐Based Submucosal Lifting Hydrogel for Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection

Advanced Healthcare Materials, EarlyView.
A biocompatible sodium alginate‐based hydrogel is developed as a next‐generation submucosal lifting agent intended for EMR and ESD. The optimized formulation exhibits a composition devoid of endotoxins, high viscosity, demonstrates reliable injectability, and ensures prolonged mucosal elevation.
Iram Maqsood, Venkata S. Akshintala, Surya T. Evani, Rebecca A. Krimins, Yihan Wang, Keith Freel, Ahmed Ibrahim, Saowanee Ngamruengphong, Mouen Khashab, Stephen W. Hoag   +9 more
wiley   +1 more source

The comparison between steroid and hypertonic saline 10% with steroid in transforaminal epidural injection in patients with unilateral foraminal stenosis [PDF]

International Clinical Neuroscience Journal, 2015
Background: Chronic radicular low back pain is a common disease that limits patient’s daily activity. Epidural steroid injection is becoming the mainstay of therapies for radicular low back pain due to contained bulged disc.
Behnam Hosseini, Mohammad Hossein Ataei, Sirous Momenzadeh, Reza Jalili Khoshnood, Davood Ommi   +4 more
doaj   +1 more source