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Tolerability of hypertonic injectables

International Journal of Pharmaceutics, 2015
Injectable drug products are ideally developed as isotonic solutions. Often, hypertonic injectables may have to be marketed for a variety of reasons such as product solubilization and stabilization. A key concern during product formulation development is the local and systemic tolerability of hypertonic products upon injection.
openaire   +2 more sources

Hypertonicity‐induced cation channels

Acta Physiologica, 2006
AbstractWhenever studied in a quantitative fashion, hypertonicity‐induced cation channels (HICCs) are found to be the main mediators of regulatory volume increase. In most instances, these channels are either inhibited by amiloride (but insensitive to Gd3+ and flufenamate) or they are efficiently blocked by Gd3+ and flufenamate (but insensitive to ...
Wehner, F.   +5 more
openaire   +3 more sources

Hemolysis by Saponin Is Accelerated at Hypertonic Conditions

Molecules, 2023
Miroslav Karabaliev   +2 more
exaly  

Hypertonic Hemodiafiltration

The International Journal of Artificial Organs, 1988
openaire   +2 more sources

Hypertonicity

2023
openaire   +1 more source

Hypertonic Saline

Journal of Neurosurgery, 2008
Mauro Bergui, Gianni Boris Bradac
openaire   +1 more source

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