Results 31 to 40 of about 40,726 (247)

Randomised controlled trials may underestimate drug effects: balanced placebo trial design.

PLoS ONE, 2014
BackgroundIt is an inherent assumption in randomised controlled trials that the drug effect can be estimated by subtracting the response during placebo from the response during active drug treatment.ObjectiveTo test the assumption of additivity.
Karen Lund, Lene Vase, Gitte L Petersen, Troels S Jensen, Nanna B Finnerup   +4 more
doaj   +1 more source

Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis. [PDF]

PLoS ONE, 2016
Protein function is controlled by the cellular proteostasis network. Proteostasis is energetically costly and those costs must be balanced with the energy needs of other physiological functions.
Elaine C Lee, Heejung Kim, Jennifer Ditano, Dacie Manion, Benjamin L King, Kevin Strange   +5 more
doaj   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Avaliação laboratorial do uso de solução salina hipertônica e isotônica e de furosemida no tratamento da intoxicação por amônia em bovinos Laboratorial evaluation of hypertonic and isotonic saline solution and furosemide use for the ammonia poisoning treatment in cattle

Ciência Rural, 2010
Para testar a eficiência de vários tratamentos de intoxicação por amônia em bovinos, foram utilizados 25 garrotes que receberam cloreto de amônio por infusão intravenosa (iv) até o surgimento de quadro convulsivo. Em seguida, os animais foram alocados em
Sandra Satiko Kitamura, Alexandre Coutinho Antonelli, Celso Akio Maruta, Maria Claudia Araripe Sucupira, Clara Satsuki Mori, Letícia Andreza Yonezawa, Lilian Emy dos Santos Michima, Pierre Castro Soares, Enrico Lippi Ortolani   +8 more
doaj  

Exploring the cardiovascular effects of hypertonic lactate: a systematic review of animal studies

Exploration of Medicine
Background: The naturally occurring metabolite lactate has traditionally been considered as a waste product of anaerobic metabolism whose production was confined to hypoxic states.
Oskar Kjærgaard Hørsdal
doaj   +1 more source

Hypertonic stress modulates eNOS function through O-GlcNAc modification at Thr-866

Scientific Reports, 2021
O-GlcNAcylation, an energy-sensitive posttranslational modification, can regulate the activity of endothelial nitric oxide synthase (eNOS). Previous studies found that Thr866 is the key site for low-glucose-mediated regulation of eNOS O-GlcNAc.
Chang Li, An He, Yongzheng Guo, Xiyang Yang, Minghao Luo, Zhe Cheng, Longxiang Huang, Yong Xia, Suxin Luo   +8 more
doaj   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Mannitol versus mannitol with hypertonic saline for brain relaxation during craniotomies using ultra-sonographic optic nerve sheath diameter

Alexandria Journal of Medicine
Background This study compared the effect of conventional doses of mannitol alone versus combined lower doses of mannitol-hypertonic saline on brain debulking during elective craniotomies.Patients and methods Sixty participants aged 18–60 years, ASA ...
Eslam Mohammed Ahmed El-Genaidy, Said Mohamed El-Medany, Ashraf Arafat Abdelhalim, Ragab Saad Beltagy, Tarek Ahmed Rayan   +4 more
doaj   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

Advanced NanoBiomed Research, EarlyView.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen, Michael B. Nguyen, Elliot Widd, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Houston Harding, Chloe Hurteau, Anika Yogi, Colin Luo, Rebecca L. Braden, Pedro Cabrales, Karen L. Christman   +14 more
wiley   +1 more source