Results 121 to 130 of about 98,812 (291)

Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice

Andrology, EarlyView.
Abstract Background Inhibition of sperm maturation in the epididymis is a promising post‐testicular strategy for short‐acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice.
Yuki Oyama, Kentaro Shimada, Haruhiko Miyata, Rie Iida‐Norita, Chihiro Emori, Maki Kamoshita, Seiya Oura, Ryohei Katayama, Martin M. Matzuk, Masahito Ikawa   +9 more
wiley   +1 more source

Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study

Acta Medica Iranica, 2019
Hypertriglyceridemia is a common form of dyslipidemia and is associated with several comorbidities, such as increased risk of pancreatitis and cardiovascular diseases (CVD).
Alireza Heidari-Bakavoli, Seyed Mahdi Hassanian, Amir Avan, Mojtaba Shafiee, Afsane Bahrami, Maryam Tayefi, Samaneh Khakpouri, Parvin Zamani, Mohsen Moohebati, Mahmoud Ebrahimi, Farzad Rahmani, Habibollah Esmaeili, Mohsen Nematy, Mohammad Safarian, Gordon A. Ferns, Mahmoud Reza Azarpajouh, Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan   +17 more
doaj  

Identification and Validation of Hub Genes in Acute Pancreatitis and Hypertriglyceridemia

Diabetes, Metabolic Syndrome and Obesity, 2022
Shiyu Zhang, Zhihai Liang, Xuelian Xiang, Li Liu, Huiying Yang, Guodu Tang Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Province, People’s Republic of ChinaCorrespondence: Guodu Tang ...
Zhang S, Liang Z, Xiang X, Liu L, Yang H, Tang G   +5 more
doaj  

Impact of age at first visit on glycolipid metabolism, bone metabolism, and fertility potential in patients with Klinefelter syndrome

Andrology, EarlyView.
Abstract Background Classic Klinefelter syndrome (KS) is characterized by one extra X chromosome (47, XXY), leading to hypergonadotropic hypogonadism and higher risk of alterations in glycolipid homeostasis, cardiovascular diseases, and low bone mineral density. Most frequently, KS is diagnosed in adulthood because of infertility.
Giordana Ferraioli, Andrea Graziani, Noemi Sagone, Andrea Di Nisio, Massimo Iafrate, Fabrizio Dal Moro, Alberto Ferlin, Andrea Garolla   +7 more
wiley   +1 more source

ApoE gene therapy: an overview and update [PDF]

, 2005
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core  

Upadacitinib for Induction of Remission in Paediatric Crohn's Disease: An International Multicentre Retrospective Study

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 8, Page 1372-1380, April 2025.
This multicentre retrospective study from 30 centers worldwide found that upadacitinib was an effective and safe induction therapy for refractory paediatric Crohn's disease. Efficacy should be weighed against the potential risks of adverse events. ABSTRACT Background There are scarce data available on upadacitinib in children with Crohn's disease (CD).
Shlomi Cohen, Elizabeth A. Spencer, Michael T. Dolinger, David L. Suskind, Katarina Mitrova, Ondrej Hradsky, Máire A. Conrad, Judith R. Kelsen, Holm H. Uhlig, Christos Tzivinikos, Paul Henderson, Magdalena Wlazlo, Lukas Hackl, Dror S. Shouval, Matteo Bramuzzo, Darja Urlep, Christine Olbjørn, Giulia D'Arcangelo, Gemma Pujol‐Muncunill, Dotan Yogev, Ben Kang, Marco Gasparetto, Christine Rungoe, Kaija‐Leena Kolho, Iva Hojsak, Lorenzo Norsa, Firas Rinawi, Naire Sansotta, Ramit Magen Rimon, Maya Granot, Luca Scarallo, Eunice Trindade, Marta Velasco Rodríguez‐Belvís, Dan Turner, Anat Yerushalmy‐Feler   +34 more
wiley   +1 more source

The triglyceride to high-density lipoprotein ratio identifies children who may be at risk of developing cardiometabolic disease [PDF]

, 2014
Aim: It is important to develop simple, reliable methods to identify high-risk individuals who may benefit from intervention. This study investigated the association between the triglyceride to high-density lipoprotein cholesterol (TG/HDL) ratio and ...
Baker, Berenson, Boddy, Bonito, Chen, Chu, Cole, Department for Communities and Local Government, Ekelund, Giannini, Hannon, Li, Mattocks, McCarthy, McLaughlin, Millan, National Cholesterol Education Panel, National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents, Nguyen, Olson, Parikh, Riddoch, Rowlands, Ruiz, Twisk, Urbina, Weiss, Yunke, Zimmet   +28 more
core   +1 more source

Clearance of Hepatitis C Viremia During Direct‐Acting Antiviral Therapy Leads to Rapid Changes in Lipid and Lipoprotein Metabolism

Alimentary Pharmacology &Therapeutics, EarlyView.
HCV clearance during direct‐acting antiviral therapy rapidly increases serum lipids and lipoproteins, potentially elevating cardiovascular risk. These metabolic changes, mediated by genes regulating hepatic lipogenesis, suggest that lipid levels should be closely monitored post‐SVR to assess long‐term cardiovascular implications.
Zahra Sarrafan‐Chaharsoughi, Varun Takyar, Sungyoung Auh, Gavin Nee, Ahmad Alawad, Brent S. Abel, Devika Kapuria, Colleen Byrnes, Anna Wolska, David E. Kleiner, Robert Shamburek, Alan T. Remaley, Marc G. Ghany   +12 more
wiley   +1 more source

Role of Insulin in Endogenous Hypertriglyceridemia* [PDF]

, 1967
Gerald M. Reaven, Roger L. Lerner, Michael P. Stern, John W. Farquhar   +3 more
openalex   +1 more source

Hypertriglyceridemia and cardiovascular risk: a cautionary note about metabolic confounding

Journal of Lipid Research, 2018
Triglycerides are the conventional tool to measure VLDLs, whereas LDL cholesterol (LDL-C) is the conventional tool to measure LDLs. Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated that cardiovascular ...
A. Sniderman, P. Couture, S. Martin, J. DeGraaf, P. Lawler, W. Cromwell, J. Wilkins, G. Thanassoulis   +7 more
semanticscholar   +1 more source