Results 161 to 170 of about 56,666 (257)

Plasma proteomics of cerebrovascular disease, cognitive decline, and clinical outcomes

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION The plasma proteomic signatures underlying cerebrovascular disease (CeVD) remains poorly understood. METHODS A total of N = 2534 participants across two independent longitudinal Southeast‐Asian cohorts were included. We profiled 1441 baseline plasma proteins in a memory‐clinic cohort (N = 518), followed‐up for 4 years.
Ming Ann Sim, Saima Hilal, Jasper Tromp, Eugene S. J. Tan, James Doecke, Oi Wah Liew, Vera Yuan Cai, Siew Pang Chan, Eddie Jun Yi Chong, Anqi Toh, Tan Boon Yeow, Narayanaswamy Venketasubramanian, Natasha Barascuk‐Michaelsen, David Sim, Gerard Kui Toh Leong, Daniel Poh Shuan Yeo, Hean Yee Ong, Lieng Hsi Ling, Carolyn Lam, Mitchell K. P. Lai, Hyungwon Choi, Arthur Mark Richards, Christopher L. H. Chen   +22 more
wiley   +1 more source

Apical Hypertrophic Cardiomyopathy in ATTR Val142Ile Carrier: When Genes and Phenotype Diverge. [PDF]

JACC Case Rep
Khayat O, Moumneh MB, Salman O, Jia K, Zayed A, Abofrekha B, Itani H, Dulnuan K.   +7 more
europepmc   +1 more source

Successful Bortezomib–Lenalidomide–Dexamethasone Therapy in a 72‐Year‐Old Patient With Sporadic Late‐Onset Nemaline Myopathy Associated With Monoclonal Gammopathy of Muscle Significance

Muscle &Nerve, Volume 74, Issue 3, Page 756-758, September 2026.
Hiroki Komatsu, Shogo Komaki, Meiko Maeda, Akatsuki Kubota, Mitsuhiro Yuasa, Mineo Kurokawa, Ryo Morishima, Satoko Uruha, Akinori Uruha, Ichizo Nishino, Masashi Hamada, Tatsushi Toda, Wataru Satake   +12 more
wiley   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2723-2740, August 2026.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Surgical management of hypertrophic cardiomyopathy. [PDF]

Indian J Thorac Cardiovasc Surg
Ananthanarayanan C, Modugula SR, Chauvette V, Ragheb D, Bhagat R, Smedira N.   +5 more
europepmc   +1 more source

TET2 as a Context‐Dependent Epigenetic Integrator in Clonal Hematopoiesis, Inflammation, Cancer, and Immunotherapy

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Ten‐Eleven Translocation 2 (TET2) is an Fe(II)‐ and α‐ketoglutarate‐dependent dioxygenase that initiates active DNA demethylation by oxidizing 5‐methylcytosine (5mC). Beyond this enzymatic role, TET2 links DNA methylation dynamics with chromatin regulation, cellular metabolism, immune‐cell identity, and treatment response in a context ...
XiaoJie Liu, Jiangchen Liu, Liu Feng, Dan Xu, Xianling Wei, Dekuai Tong   +5 more
wiley   +1 more source

Clinical Spectrum and Outcomes in Hypertrophic Cardiomyopathy With Apical Aneurysms: A Large Multicenter International Cohort. [PDF]

JACC Adv
Rowin EJ, Lee DZJ, Sherrid MV, Maron BJ, Tower-Rader AF, Zocchi C, Ahamed H, Hari A, Albano AJ, Chacko L, Varnava AM, Bokhari N, Madias C, Carrick RT, Madrazo J, Rakowski H, Adler A, Fifer MA, Olivotto I, Massera D, Maron MS, Chan RH.   +21 more
europepmc   +1 more source

Nine‐Year Follow‐Up After M‐TEER for Secondary Mitral Regurgitation in a Patient With Cardiogenic Shock

Catheterization and Cardiovascular Interventions, Volume 108, Issue 2, Page 483-488, August 1, 2026.
ABSTRACT Background Transcatheter edge‐to‐edge repair (TEER) has become an established therapeutic option for patients with severe secondary mitral regurgitation (SMR). While randomized trials and registry data have reported outcomes up to 5 years, longer follow‐up data remain scarce.
Tobias Reithmayer, Thomas J. Stocker, Ludwig T. Weckbach, Julia Novotny, Philipp M. Doldi, Hannah Kempton, Steffen Massberg, Michael Näbauer, Jörg Hausleiter, Lukas Stolz   +9 more
wiley   +1 more source

KLHL24-Associated Hypertrophic Cardiomyopathy: When Genotype Outpaces Phenotype. [PDF]

JACC Case Rep
Kumar P, Ansari AG, Sasikumar D, Namboodiri N.   +3 more
europepmc   +1 more source

Unveiling New Insights: Reinterpreting DES Mutation, p.Arg383His, Through a Study of an Iranian Family With Isolated Hypertrophic Cardiomyopathy, Implication for Phenotype–Genotype Correlation Analysis

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi, Farzad Kamali, Bahareh Rabbani, Mehrdad Behmanesh, Nejat Mahdieh, Mehrdad Noruzinia   +5 more
wiley   +1 more source