Results 241 to 250 of about 192,948 (305)

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

British Journal of Pharmacology, EarlyView.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan, Alanna G. Spiteri, Pranav Runwal, Jiaqi Sun, Dana S. Hutchinson, Yoshiteru Kagawa, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo   +10 more
wiley   +1 more source

Bicuspid pulmonary and bicuspid aortic valve in association with Gasul phenomenon (triple combination): a case report and literature review. [PDF]

Egypt Heart J
Karuru UD, Naveen T, Mysore SK, Tummala SR, Parhi A, Kanjerla KK.   +5 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study. [PDF]

World J Diabetes
Yu JJ, Han JG, Tan Y, Xu JX, LeBlanc A, Keller BB, Huang J, Cai L.   +7 more
europepmc   +1 more source

Hypertrophic Cardiomyopathy in a Fetus: A Rare Presentation Case Report. [PDF]

Clin Case Rep
Golbabaei A, Moghaddam ESA, Naemi M, Mohammad Talebi H.   +3 more
europepmc   +1 more source

Serum alpha-1-microglobulin as a predictor of multiple complications in type 2 diabetes mellitus patients. [PDF]

World J Diabetes
Ge LC, Zhang YL, Peng GL, Long M, Jin T, Lu B, Shao JQ, Li X.   +7 more
europepmc   +1 more source

Unexplained cardiac hypertrophy as a clue to plasma cell tumour: a case study. [PDF]

Am J Transl Res
Liu S, Tong C, Xie J, Zang S.
europepmc   +1 more source

Blood Pressure Variability in Hypertension: A Rehabilitation Perspective. [PDF]

J Cardiovasc Dev Dis
Raju M, Perrone MA, Alashram AR, Iellamo F.   +3 more
europepmc   +1 more source

Atrioventricular Block in a Pompe Disease Patient Receiving Enzyme Replacement Therapy. [PDF]

JACC Case Rep
Akagi K, Baba S, Matsuda K, Yoshida T, Hirata T, Yokoyama A, Yoneda F, Fukumura F, Kume E, Takita J.   +9 more
europepmc   +1 more source