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Introduction Adenotonsillar hypertrophy is more common in children with sickle cell disease, and can lead to sleep-disordered breathing. Objectives To determine the frequency of adenotonsillar hypertrophy in pre-school children with sickle ...
Carlos Rodolfo Tavares de Góis+4 more
doaj +1 more source
Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
Summary: Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators.
Tanner Stokes+13 more
doaj +1 more source
Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 ...
Wenyuan G. Zhu+8 more
doaj +1 more source
Micro-RNA family that modulates fibrosis and uses thereof [PDF]
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response
Olson, Eric N., van Rooij, Eva
core +1 more source
Mechanics of chondrocyte hypertrophy [PDF]
Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
van Cc René Donkelaar, W Wouter Wilson
openaire +4 more sources
Guiding progenitor cell development between chondral versus endochondral pathways is still an unachieved task of cartilage neogenesis, and human mesenchymal progenitor cell (MPC) chondrogenesis is considered as a valuable model to better understand ...
Simon I. Dreher+4 more
doaj +1 more source
The role of reactive astrocitose in the chronological evolution of traumatic brain injury [PDF]
Introduction and objectives. This study aims to investigate whether the cerebral modifications of posttraumatic reactive astrocitose can be considered an objective criterion for determining the age of traumatic cranio-cerebral lesions.
Belis, Vladimir+5 more
core +4 more sources
CAMTA in Cardiac Hypertrophy [PDF]
In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction ...
Michael D. Schneider+2 more
openaire +3 more sources
Pre-Participation Cardiac Screening: consideration for Young Athletes [PDF]
This article is the first of two focusing on the utility and evidence base for pre-participation cardiac screening in competitive athletic populations.
Ingle, L
core +1 more source
ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy
Cardiac hypertrophy is an adaptive and compensatory mechanism preserving cardiac output during detrimental stimuli. Nevertheless, long-term stimuli incite chronic hypertrophy and may lead to heart failure. In this review, we analyze the recent literature
Simona Gallo+4 more
semanticscholar +1 more source