Results 61 to 70 of about 324,212 (297)

Liquiritin Exerts a Dual Effect on BMSCs Osteogenic Differentiation and Fracture Healing by Activating the ERK/JNK Pathway and Providing Antioxidant Protection

Advanced Therapeutics, EarlyView.
Liquiritin enhances the osteogenic differentiation of BMSCs and promotes fracture healing through the activation of the ERK/JNK signaling pathway and by exerting antioxidant protective effects. Abstract Liquiritin, a flavonoid from Glycyrrhiza uralensis L., has diverse pharmacological properties, but its impact on fracture healing is unexplored.
Haijun Mao, Jing Liu, Juan Feng, Yalikun Yusufu, Lei Yang, Qing Jiang, Minghui Sun   +6 more
wiley   +1 more source

The effects of double-pyramid resistance and pyramid speed training on some physiological adaptations of young elite football players

Revista Brasileira de Futsal e Futebol, 2021
This study aimed to investigate the effects of the double-pyramid resistance training (DPRT) and the pyramid speed training (PST) on some physiological adaptations of Young elite football players.
Mohammad Mohammadi, Azadeh Naderi, Farah Asadi   +2 more
doaj  

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice

Journal of Lipid Research, 2011
Alkaline sphingomyelinase (alk-SMase) hydrolyses sphingomyelin (SM) to ceramide in the gut. To evaluate the physiological importance of the enzyme, we generated alk-SMase knockout (KO) mice by the Cre-recombinase-Locus of X-over P1(Cre-LoxP) system and ...
Yao Zhang, Yajun Cheng, Gert H. Hansen, Lise-Lotte Niels-Christiansen, Frank Koentgen, Lena Ohlsson, Åke Nilsson, Rui-Dong Duan   +7 more
doaj  

Superimposed Whole-Body Electrostimulation Augments Strength Adaptations and Type II Myofiber Growth in Soccer Players During a Competitive Season

Frontiers in Physiology, 2019
BackgroundThe improvement of strength and athletic performance during a competitive season in elite soccer players is a demanding task for the coach.AimsAs whole-body electrostimulation (WB-EMS) training provides a time efficient stimulation potentially ...
Andre Filipovic, Markus DeMarees, Marijke Grau, Anna Hollinger, Benedikt Seeger, Thorsten Schiffer, Wilhelm Bloch, Sebastian Gehlert, Sebastian Gehlert   +8 more
doaj   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

Neurogenic muscle hypertrophy [PDF]

Neurology, 2014
A 42-year-old man had a 2-year history of progressive asymptomatic left calf enlargement. MRI showed diffuse swelling of left calf muscles (figure, A and B); biopsy displayed neurogenic changes (figure, C and D). Electrodiagnostic examination results were compatible with left chronic S1 radiculopathy and lumbosacral MRI revealed an ipsilateral L5-S1 ...
Lattanzi, Simona, Cagnetti, Claudia, Di Bella, Paolo, Scarpelli, Marina, Provinciali, Leandro, Silvestrini, Mauro   +5 more
openaire   +2 more sources

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

Advanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou, Jiangfang Lian   +10 more
wiley   +1 more source

MEF2 and the Right Ventricle: From Development to Disease

Frontiers in Cardiovascular Medicine, 2019
Pulmonary arterial hypertension is a progressive and ultimately life-limiting disease in which survival is closely linked to right ventricular function.
Katharine R. Clapham, Inderjit Singh, Isabella S. Capuano, Isabella S. Capuano, Sudarshan Rajagopal, Hyung J. Chun   +5 more
doaj   +1 more source

An Injectable BMP‐2‐Releasing Porous Hydrogel Regulating the Paracrine Effects of ADSCs Promotes Tendon‐to‐Bone Healing in Rotator Cuff Repair

Advanced Science, EarlyView.
This study designs an injectable porous hydrogel (HMs/MBs/ADSCs) integrating hollow microspheres for sustained BMP‐2 release to enhance adipose‐derived stem cells' paracrine effect. It accelerates tendon‐bone healing in rat rotator cuff injuries via spatiotemporal regulation: early AMPK‐mediated mitochondrial protection and late TGF‐β/Smad2/3‐driven ...
Meijuan Yuan, Xiaomei Dai, Yuxia Yang, Shuai Liu, Ziyi Xu, Liang Wang, Junli Shi, Wenkang Liu, Jian Yang, Dianwei Liu, Hang Yao, Wenyong Fei   +11 more
wiley   +1 more source