Results 61 to 70 of about 760,497 (383)

Myocardial Hibernation in Patients with Arterial Hypertension and Ischemic Heart Disease as a Cause of Heart Failure

Львівський клінічний вісник, 2013
Introduction. Myocardial hibernation refers to “new ischemic syndromes,” which in recent years have increasingly attracted the attention of cardiologists and cardiac surgeons.
Barnett O. , Kyyak Y., Kyyak H., Kovalyshyn V., Besh D.   +4 more
doaj   +1 more source

Of mice and men: Pinpointing species differences in adipose tissue biology

Frontiers in Cell and Developmental Biology, 2022
The prevalence of obesity and metabolic diseases continues to rise, which has led to an increased interest in studying adipose tissue to elucidate underlying disease mechanisms. The use of genetic mouse models has been critical for understanding the role
Emma Börgeson, Emma Börgeson, Emma Börgeson, Jeremie Boucher, Jeremie Boucher, Carolina E. Hagberg, Carolina E. Hagberg   +6 more
doaj   +1 more source

Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy

Scientific Reports, 2018
It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 CpGs) and gene expression analysis after muscle hypertrophy (loading ...
Robert A. Seaborne, J. Strauss, M. Cocks, S. Shepherd, T. D. O’Brien, Ken A. van Someren, P. Bell, C. Murgatroyd, J. Morton, C. Stewart, A. Sharples   +10 more
semanticscholar   +1 more source

Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy. [PDF]

, 2002
BackgroundIron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility, 2) abdominal aorta would be larger ...
Chew, Herbert George, Gibbs, Brett Jason, Hearthway, Megan Lesley, Motsko, Madelyne, Mullendore, Michael Eugene, Premo, Daniel Aaron, Sappington, Andrea, Turner, Lexa Rae, Walker, LeeAnn   +8 more
core   +1 more source

Prognostic value of left ventricular mass index in patients with mild and moderate aortic stenosis

Кардиоваскулярная терапия и профилактика, 2019
Aim. To study the prognostic value of Left Ventricular Mass (LVM) with asymptomatic aortic stenosis (AS) in a long-term outpatient study, as well as the effect of the LVM on major cardiovascular events (CVe).Material and methods.
A. S. Ryazanov, M. V. Makarovskaya, K. I. Kapitonov, A. A. Kudryavtsev   +3 more
doaj   +1 more source

Whole-slide image analysis outperforms micrograph acquisition for adipocyte size quantification

Adipocyte, 2020
The distinction between biological processes of adipose tissue expansion is crucial to understanding metabolic derangements, but a robust method for quantifying adipocyte size has yet to be standardized.
Anne S Maguire, Lauren N Woodie, Robert L Judd, Douglas R Martin, Michael W Greene, Emily C Graff   +5 more
doaj   +1 more source

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1−SMAD1 interaction

Bone Research, 2019
Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.
Chengjie Lian, Xudong Wang, X. Qiu, Zizhao Wu, Bo Gao, Lei Liu, Guo-yan Liang, Hang Zhou, Xiaoming Yang, Yan Peng, Anjing Liang, Caixia Xu, Dongsheng Huang, Peiqiang Su   +13 more
semanticscholar   +1 more source

Risk factors for obstructive sleep apnea syndrome in children: state of the art [PDF]

, 2019
The obstructive sleep apnea syndrome (OSAS) represents only part of a large group of pathologies of variable entity called respiratory sleep disorders (RSD) which include simple snoring and increased upper airway resistance syndrome (UARS).
Bellini, Chiara, Cammaroto, G., Colizza, A., de Vincentiis, M., De Vito, A., Firinu, E., Gobbi, R., Greco, A., Gulotta, G., Iannella, G., Magliulo, G., Meccariello, G., Pace, A., Pelucchi, S., Polimeni, A., Vicini, C., Visconti, I. C.   +16 more
core   +2 more sources

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Expression of Estrogen Receptor Alpha and Evaluation of Histological Degeneration Scores in Fibroblasts of Hypertrophied Ligamentum Flavum: A Qualitative Study

Biomolecules, 2021
The most common spinal disorder in elderly is lumbar spinal stenosis (LSS), resulting partly from ligamentum flavum (LF) hypertrophy. Its pathophysiology is not completely understood.
Christina C. Westhoff, Christian-Dominik Peterlein, Hanna Daniel, Juergen R. Paletta, Roland Moll, Annette Ramaswamy, Stefan Lakemeier   +6 more
doaj   +1 more source