Results 101 to 110 of about 36,842 (245)

Hyperuricemia induces endothelial dysfunction [PDF]

, 2005
Hyperuricemia induces endothelial dysfunction.BackgroundHyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction.
Finch, Jennifer L., Zharikov, Sergey, Roncal, Carlos, Block, Edward R., Prabhakar, Sharma, Nakagawa, Takahiko, Khosla, Uday M., Mu, Wei, Krotova, Karina, Johnson, Richard J.   +9 more
core   +1 more source

Hyperuricemia in predialysis chronic kidney disease patients in Southern Nigeria [PDF]

, 2016
Background: Cardiovascular disease (CVD) is the leading cause of hospitalization and death in chronic kidney disease (CKD) patients. Hyperuricemia has emerged as one of the nontraditional cardiovascular risk factors. Studies have shown that hyperuricemia
Chimezie G Okwuonu, Enajite I Okaka, Oluseyi A Adejumo, Louis I Ojogwu   +3 more
core   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Inflammatory Bowel Disease Is Associated With an Increased Risk of End‐Stage Renal Disease: A Population‐Based Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In a retrospective population‐based cohort study using the University of Manitoba IBD Epidemiology Database, persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD ...
Onuma Sattayalertyanyong, Zoann Nugent, Bryce Barr, Keevin N. Bernstein, Charles N. Bernstein   +4 more
wiley   +1 more source

Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications

Diabetes, Metabolic Syndrome and Obesity, 2020
Min Gong, Song Wen, Thiquynhnga Nguyen, Chaoxun Wang, Jianlan Jin, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of ...
Gong M, Wen S, Nguyen T, Wang C, Jin J, Zhou L   +5 more
doaj  

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Hyperuricemia after renal transplantation [PDF]

, 2011
Background: Hyperuricemia is a common complication after kidney transplantation, and may adversely affect graft survival. Objective: To assess the prevalence of and predictors for development of hyperuricemia after renal transplantation.
Einollahi, B., Hossieni, M.-S., Khalili, N., Kalantar, E., Rostami, Z.   +4 more
core  

Association of Sodium‐Glucose Cotransporter‐2 Inhibitors With Incident Gout Risk: A Population‐Based Comparative Cohort Study With Genetic Evidence From Mendelian Randomisation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are known to reduce serum urate levels, yet their specific impact on gout incidence in the Korean population remains underexplored. We investigated the association between SGLT2i use and incident gout using real‐world data and Mendelian randomisation (MR) analysis. Materials and Methods We
Hong Sang Choi, Jaejun Heo, Sungho Won, Sang Heon Suh, Chang Seong Kim, Eun Hui Bae, Juhee Ahn, Soo Wan Kim   +7 more
wiley   +1 more source

Hyperuricemia and cardiovascular risk: Insights and implications [PDF]

Hyperuricemia, characterized by elevated serum uric acid levels, has been linked to cardiovascular diseases such as hypertension, atrial fibrillation, chronic kidney disease, heart failure, metabolic syndrome, and coronary artery disease.
Abu Rmilah, Anan, Assaassa, Abdalrahman, Neiroukh, Haroun, Nair, Kiran, Milhem, Fathi, Shubietah, Abdalhakim, Nouri, Ahmad, Sahni, Ankit, Hattab, Moath, Ghannam, Mohammad, Zahdeh, Massa, Awashra, Ameer, Rajab, Islam   +12 more
core   +1 more source

Association between serum urate, gout and chronic kidney disease: a scoping review of systematic reviews and meta-analyses

Journal of Rheumatic Diseases
Hyperuricemia is highly prevalent in patients with chronic kidney disease (CKD) due to reduced renal urate clearance, which leads to an increased incidence of gout in this population.
Yoon-Jeong Oh, Jung-Min Shin, Jin-Wuk Hur, Chang-Nam Son   +3 more
doaj   +1 more source