Results 101 to 110 of about 50,456 (255)

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song, Di Liu, Shi Chen, Yufeng Tan, Siyu Wang, Shihan Li, Yutong Qin, Guofeng Li, Xufang Tian, Lan Yang, Chong Yuan, Junbo Gou, Wei Huang, Shilin Chen, Yifei Liu   +14 more
wiley   +1 more source

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1650-1661, June 2026.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Fat reduction mediates the efficacy of intensive lifestyle interventions on fertility‐sparing treatment in overweight patients with endometrial cancer and intraepithelial neoplasia

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 6, Page 1052-1063, June 2026.
Intensive lifestyle interventions‐based weight management targeting fat reduction may enhance fertility‐sparing treatment outcomes in overweight patients with endometrial cancer or its precursor. Our findings advocate the integration of body composition‐guided weight management into standardized protocols.
Sijia Liu, Li Li, Pengfei Wu, Lulu Wang, Qujia Gama, Manrong Wang, Jinyu Zhang, Liping Jin, Xuezhen Luo, Weiwei Shan, Bingyi Yang   +10 more
wiley   +1 more source

Higher Atherogenic Index of Plasma Is Associated with Hyperuricemia: A National Longitudinal Study

International Journal of Endocrinology
Background. The association between atherogenic index of plasma (AIP) and hyperuricemia remains indistinct. This study was aimed to examine the relationship between AIP and hyperuricemia among the middle-aged and the elderly Chinese population.
Feifei Xu, Chengyong Ma, Shouping Wang, Qin Li, Zhongwei Zhang, Min He   +5 more
doaj   +1 more source

Gouty Tophi of the Fingertips Induced by Repeated Microtrauma

JEADV Clinical Practice, EarlyView.
A. Gotor‐Rivera, R. F. Matilla‐Naumionek, J. L. Rodríguez‐Peralto, B. González Rodríguez   +3 more
wiley   +1 more source

Association Between Furosemide and Risk of Parkinson's Disease in a Nested Case–Control Study

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 6, June 2026.
ABSTRACT A French signal detection study identified an association between sulfonamide diuretics use, particularly furosemide, and lower Parkinson's disease (PD) risk. Our aim was to confirm this association in a Finnish nationwide nested case–control study (FINPARK), primarily in an indication‐restricted case–control study of persons with heart or ...
Barkat Babar, Anne Paakinaho, Emeline Courtois, Isabell Rumrich, Yanis Saidi, Alexis Elbaz, Anne C. M. Thiébaut, Ismaïl Ahmed, Miia Tiihonen, Sirpa Hartikainen, Anna‐Maija Tolppanen   +10 more
wiley   +1 more source

Safety, Tolerability, and Pharmacokinetics of Mirvetuximab Soravtansine in Chinese Patients With Folate Receptor α‐Positive Advanced Ovarian Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Folate receptor α (FRα) is a glycosylphosphatidylinositol‐anchored protein that facilitates folate transport and has emerged as a promising therapeutic target for ovarian cancer, particularly due to its association with tumor progression.
Yongsheng Li, Li Yuan, Ge Lou, Hongbing Cai, Yuzhi Li, Fenghu Li, Li Wang, Xingtao Long, Yi Gong, Chaonan Zhu, Li Li, June Xu, Qi Zhou   +12 more
wiley   +1 more source

Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study

Frontiers in Pharmacology
BackgroundStatins are one of the most widely prescribed medicines in clinical practice. Their benefits have extended beyond cardiovascular applications to reduce serum uric acid levels.
Bin Zhu, Zijun He, Mingfen Wu, Jiping Huo, Zhigang Zhao, Wei Guo, Li Yang   +6 more
doaj   +1 more source

The main aspects of metabolism for patients with osteochondrosis, arterial hypertension and type 2 diabetes mellitus [PDF]

, 2016
Importance. Abdominal obesity (АO) is the component of metabolic syndrome. The accumulation of fat cells stimulates the excessive load of lumbar vertebrae.
Chernatska, Olha Mykolaivna, Demikhova, Nadiia Volodymyrivna, Sakalyte, Gintare, Демихова, Надежда Владимировна, Деміхова, Надія Володимирівна, Чернацкая, Ольга Николаевна, Чернацька, Ольга Миколаївна   +6 more
core  

Fruquintinib Plus TAS‐102 With or Without SBRT as Third‐ Or Later‐Line Therapy for Metastatic Colorectal Cancer: Preliminary Results From a Prospective Phase II Trial

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Both fruquintinib and TAS‐102 monotherapies are guideline‐recommended for third‐line treatment of metastatic colorectal cancer (mCRC). This study aimed to analyze the preliminary outcomes of fruquintinib combined with TAS‐102, with or without stereotactic body radiation therapy (SBRT), as a third‐ or later‐line therapy for mCRC.
Yi Wang, Jianfen Xu, Linchun Liang, Yunjie Chen, Leizheng Fei, Jing Hu, Jianjiong Li, Yi Lu, Feng Ren, Ke Chen, Yanping Shen, Qingsong Tao, Zhi Fang, Kaitai Liu, Hua Ye, Jing Zhang, Yunbao Xu, Haoxun Mao, Chen Zhang, Chuangzhou Rao   +19 more
wiley   +1 more source