Results 11 to 20 of about 71,655 (301)

Hyperuricemia and gout increased the risk of long-term mortality in patients with heart failure: insights from the National Health and Nutrition Examination Survey

Journal of Translational Medicine, 2023
Background The prevalence of hyperuricemia, gout, and heart failure (HF) is on the rise, and these conditions often share similar risk factors. The present study aimed to evaluate the relationship among hyperuricemia, gout, HF, and all-cause mortality ...
Yingdong Han, Yu Cao, Xinxin Han, Hong Di, Yue Yin, Juan Wu, Yun Zhang, Xuejun Zeng   +7 more
doaj   +2 more sources

Hyperuricemia predicts increased cardiovascular events in patients with chronic coronary syndrome after percutaneous coronary intervention: A nationwide cohort study from Japan

Frontiers in Cardiovascular Medicine, 2023
BackgroundThe causal relationship between hyperuricemia and cardiovascular diseases is still unknown. We hypothesized that hyperuricemic patients after percutaneous coronary intervention (PCI) had a higher risk of major adverse cardiovascular events ...
Naoyuki Akashi, Masanari Kuwabara, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoko Nakao, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Masanobu Ishii, Taishi Nakamura, Kenichi Tsujita, Hisahiko Sato, Hideo Fujita, Ryozo Nagai   +21 more
doaj   +2 more sources

Exploration of the anti-hyperuricemia effect of TongFengTangSan (TFTS) by UPLC-Q-TOF/MS-based non-targeted metabonomics

Chinese Medicine, 2023
Background TongFengTangSan (TFTS) is a commonly used Tibetan prescription for gout treatment. Previously, TFTS (CF) was confirmed to have a significant uric acid-lowering effect.
Zhichao Huang, Wugang Zhang, Qiong An, Yifan Lang, Ye Liu, Huifang Fan, Haifang Chen   +6 more
doaj   +2 more sources

Associations between obesity and hyperuricemia combing mendelian randomization with network pharmacology

Heliyon
Objective: Obesity has become a global health issue and a risk factor for hyperuricemia. However, the associations between obesity and hyperuricemia are sometimes confounding.
Kailai Panlu, Zizun Zhou, Lin Huang, Lei Ge, Chengping Wen, Huiqing Lv   +5 more
doaj   +2 more sources

Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease

International Journal of Molecular Sciences, 2021
Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the end product of an exogenous purine from food and endogenously from damaged, dying, and dead cells.
H. Yanai, H. Adachi, M. Hakoshima, H. Katsuyama   +3 more
semanticscholar   +1 more source

The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications

Frontiers in Immunology, 2023
Changes in lifestyle induce an increase in patients with hyperuricemia (HUA), leading to gout, gouty arthritis, renal damage, and cardiovascular injury.
Delun Li, Siyu Yuan, Yiyao Deng, Xiaowan Wang, Shouhai Wu, Xuesheng Chen, Yimeng Li, Jianting Ouyang, Danyao Lin, Haohao Quan, Xinwen Fu, Chuang Li, Wei Mao   +12 more
semanticscholar   +1 more source

Prevalence of Hyperuricemia Among Chinese Adults: Findings From Two Nationally Representative Cross-Sectional Surveys in 2015–16 and 2018–19

Frontiers in Immunology, 2021
Objective To determine the nationwide prevalence of hyperuricemia in China and evaluate its trends and associated risk factors. Methods Using a multi-stage, stratified, cluster-randomized sampling design, two cross-sectional surveys (representative of ...
Mei Zhang, Xiaoxia Zhu, Jing Wu, Zheng-jing Huang, X. Zhang, Yu Xue, W. Wan, Chun Xing Li, Zhenping Zhao, Linhong Wang, Limin Wang, H. Zou, Maigeng Zhou   +12 more
semanticscholar   +1 more source

U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia

Redox Biology, 2022
Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and the metabolic syndrome and appears to contribute to the renal, cardiovascular and pulmonary comorbidities that are associated with these disorders.
W. Crawley, Cyprien Jungels, K. Stenmark, M. Fini   +3 more
semanticscholar   +1 more source

The effect of body weight and alcohol consumption on hyperuricemia and their attributable population fractions: A National health survey in China

Obesity Facts, 2021
Introduction: The prevalence of hyperuricemia is increasing world widely; the understanding of population attributable faction of modifiable risk factors is important for disease prevention.
Huijing He, Li Pan, Xiaolan Ren, Dingming Wang, Jianwei Du, Ze Cui, Jingbo Zhao, Hailing Wang, Xianghua Wang, Feng Liu, Lize Pa, Xia Peng, Ye Wang, Chengdong Yu, Guangliang Shan   +14 more
doaj   +1 more source

Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]

, 2020
Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro, Camandola, Simonetta, Cutler, Roy G., Feldman, Neil H., Haran, James B., Mattsona, Mark P., Seon Yoon, Jeong   +6 more
core   +1 more source