Results 21 to 30 of about 71,655 (301)
What makes gouty inflammation so variable? [PDF]
, 2017 Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core +2 more sources
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]
, 2016 BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc +12 more
core +2 more sources
Phytomedicine, 2023 BACKGROUND α-Viniferin, the major constituent of the roots of Caragana sinica (Buc'hoz) Rehder with a trimeric resveratrol oligostilbenoid skeleton, was demonstrated to possess a strong inhibitory effect on xanthine oxidase in vitro, suggesting it to be ...
Xiaoyi Guo +13 more
semanticscholar +1 more source
Serum uric acid as a marker of microvascular damage in systemic sclerosis patients [PDF]
, 2016 Background: Microvascular damage of skin and internal organs is a hallmark of systemic sclerosis (SSc). Serum uric acid (UA) represents a marker of inflammation and endothelial dysfunction.
Amoroso, Antonio +9 more
core +1 more source
Frontiers in Cardiovascular Medicine, 2022 PurposeThe purpose of this study is to investigate the effect of asymptomatic hyperuricemia on mortality of elderly patients with coronary artery disease (CAD) after elective percutaneous coronary intervention (PCI).MethodsOne thousand two hundred ninety-
Chen Chen +5 more
doaj +1 more source
Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout
Frontiers in Cellular and Infection Microbiology, 2022 The incidence of hyperuricemia (HUA) and gout continuously increases and has become a major public health problem. The gut microbiota, which colonizes the human intestine, has a mutually beneficial and symbiotic relationship with the host and plays a ...
Zhilei Wang +6 more
semanticscholar +1 more source
Uric acid is more strongly associated with impaired glucose regulation in women than in men from the general population: the KORA F4-Study. [PDF]
, 2012 High serum uric acid (UA) levels are associated with the metabolic syndrome, type 2 diabetes and cardiovascular disease. It is largely unknown whether there are gender-specific differences regarding the association between UA and prediabetic states.
Döring, Angela +5 more
core +4 more sources
The Role of the Intestine in the Development of Hyperuricemia
Frontiers in Immunology, 2022 Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout.
Hui-ming Yin, Na Liu, Jie Chen
semanticscholar +1 more source
Gut microbes, 2021 Recent studies into the beneficial effects of fermented foods have shown that this class of foods are effective in managing hyperuricemia and gout.
Ying Wu +9 more
semanticscholar +1 more source
Antiepileptic drugs reduce serum uric acid [PDF]
, 1987 Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls.
Arab +7 more
core +1 more source