Background: Dexmedetomidine (DEX) is an α2-adrenergic receptor agonist used for its sedative, analgesic, and anxiolytic effects. Non-Operating Room Anesthesia (NORA) is a modality of anesthesia that can be done under general anesthesia or procedural ...
Francisca Jerónimo Fonseca+3 more
doaj
PHARMACOLOGICAL PROPERTIES OF THALIDOMIDE (α‐PHTHALIMIDO GLUTARIMIDE), A NEW SEDATIVE HYPNOTIC DRUG [PDF]
G. Fred Somers
openalex +1 more source
ATROPIN AND DUBOISIN AS SEDATIVES AND HYPNOTICS [PDF]
n ...
openaire +1 more source
Over 20% of individuals with IBD were prescribed pain or sedative medications annually, with rising chronic and co‐prescribing rates. Risk factors included female sex, older age, Crohn's disease, and mental health conditions. Targeted interventions are needed to reduce harmful prescribing and promote safer alternatives.
Samantha Baillie+6 more
wiley +1 more source
PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury [PDF]
BACKGROUND: Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS).
Alexander, David N.+12 more
core +4 more sources
What Linked Data Can Tell Us About the Increasing Numbers of Children Entering Public Care
ABSTRACT The number of children in public care in Wales, UK, rose from the mid‐1990s to 2021. It is unclear if this change was related to increases in risk factors in parents, changes in the impact of risk factors, or changing policies and practices.
Nell Warner+4 more
wiley +1 more source
Intoxication with therapeutic and illicit drug substances and hospital admission to a Dutch university hospital [PDF]
BACKGROUND: This article describes the retrospective analysis of the patients who presented with a drug-related intoxication to the emergency department of the Erasmus Medical Centre in 2000.
Berg, B.W. (Bart) van den+5 more
core +1 more source
The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. [PDF]
The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM.
Kilduff, Thomas S+4 more
core +2 more sources
Gender and Overdose Risk Factors Among Clients Entering Residential Treatment for Opioid Use
ABSTRACT Introduction The period post‐residential treatment for opioid use is associated with heightened risk of overdose. The current study aims to: (i) describe characteristics of men and women attending residential treatment for primary opioid use; (ii) identify classes of clients based on primary opioid and other substance/s of concern and (iii ...
Chloe J. Haynes+9 more
wiley +1 more source
Drugs and Drowning: The Toxicology of Adult Drownings in Baths and Hot Tubs in Australia, 2015–2024
ABSTRACT Introduction Drowning is the third leading cause of unintentional injury death. We aimed to determine the toxicology and circumstances of all adult drowning deaths that occurred in bath/hot tubs in Australia over the period 2015–2024. Methods Retrospective study of all adult (≥ 15 years) drowning deaths in baths or hot tubs in Australia (1 ...
Shane Darke+4 more
wiley +1 more source