Results 101 to 110 of about 12,566 (201)

Does Hypoxic Burden Better Explain Sex Differences in Functional Impairments Than Apnoea‐Hypopnoea Index in Obstructive Sleep Apnoea?

Journal of Sleep Research, EarlyView.
ABSTRACT Women with obstructive sleep apnoea (OSA) report more severe functional impairments than men, despite lower apnoea‐hypopnoea index (AHI) values. This raises questions about the adequacy of AHI for capturing OSA severity. We explored sex differences in functional outcomes in OSA patients and examined whether AHI or hypoxic burden (HB) better ...
Urvashi Nanda, Yu Sun Bin, Philip de Chazal, Andrew S. L. Chan, Amanda Piper, Kristina Kairaitis, Peter A. Cistulli, Brendon J. Yee, on behalf of the Sydney Sleep Biobank Investigators, Peter Cistulli, Philip de Chazal, Yu Sun Bin, Lu Fu, Benjamin Tong, Glenn Stewart, Gary Cohen, Andrew S. L. Chan, Anna Mohammadieh, John Wheatley, Kristina Kairaitis, Stephen Lambert, Tracey Burns, Brendon Yee, Amanda Piper, Kerri Melehan, Amy Jackson, Gislaine Gauthier   +26 more
wiley   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Reactivating a Relaxation Exercise During Sleep to Influence Cortical Hyperarousal in Individuals With Frequent Nightmares

Journal of Sleep Research, EarlyView.
ABSTRACT High‐frequency EEG activity during sleep, reflecting cortical hyperarousal, has recently been incorporated into aetiology models of nightmares. However, its precise role remains insufficiently understood because experimental approaches to manipulate hyperarousal during sleep are limited.
C. Sayk, A. Probst, F. Lange, S. Eickemeier, J. Amores, H.‐V. Ngo, M. Ehsanifard, K. Junghanns, I. Wilhelm   +8 more
wiley   +1 more source

Lack of Efficacy of Low‐Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double‐Blind Placebo‐Controlled Clinical Trial

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep bruxism (SB) is a motor activity characterized by repetitive masticatory muscle contractions during sleep, commonly associated with tooth damage and jaw pain or headache. Pharmacological management strategies targeting its central nervous system‐related mechanisms remain limited.
Matheus Herreira‐Ferreira, Cibele Dal Fabbro, Gilles J. Lavigne, Juliana Stuginski‐Barbosa, Peter Svensson, Paulo César Rodrigues Conti, Leonardo Rigoldi Bonjardim   +6 more
wiley   +1 more source

Drug‐Induced Sialolithiasis—A Big‐Data Retrospective Study

Oral Diseases, EarlyView.
ABSTRACT Background Sialolithiasis pathophysiology is multifactorial, with systemic medications often hypothesised as a key contributor, particularly in older adults (Drug‐Induced Sialolithiasis). However, robust evidence supporting this theory is limited.
Gal Avishai, Gil Caspi, Akhilanand Chaurasia, Gavriel Chaushu, Daya Masri, Ehud Jonas   +5 more
wiley   +1 more source

Postoperative Sleep Disturbance and Functional Recovery Following Hip Fracture Surgery: A 13‐Month Prospective Longitudinal Cohort Study

Orthopaedic Surgery, EarlyView.
Postoperative sleep disturbance is common after hip fracture surgery and gradually improves over 13 months. Better sleep quality is independently associated with improved functional recovery, highlighting sleep as a modifiable target for postoperative rehabilitation.
Zhen Wang, Pengrui Feng, Jixi Liu, Xiao Fu, Li Cao, Zhen Zhang, Renliang Zhao, Zhou Zhong, Min Yi, Dong Wang, Baoyu Chen, Zijian Chen, Wenjie Huang, Mengkun Liu, Xiangtian Deng, Guanglin Wang   +15 more
wiley   +1 more source

Personal Values, Health Beliefs, and the Use of Complementary, Alternative and Integrative Medicine in Finland

Scandinavian Journal of Psychology, EarlyView.
ABSTRACT This study examines the relationships of personal values and health beliefs with past and intended use of complementary, alternative and integrative medicine (CAIM) in Finland. It also investigates the extent to which CAIM users and non‐users endorse holistic versus reductionistic health beliefs and whether experiencing benefits or harms from ...
Salla Ahola, Maija Pyykkönen, Pauliina Aarva   +2 more
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Acute trazodone treatment ameliorates behavioral abnormalities and improves subsequent short‐term memory in a lipopolysaccharide‐induced mouse model of acute brain dysfunction

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Aim Systemic inflammation‐associated acute brain dysfunction, typified by delirium, is linked to later cognitive impairment. Although trazodone is used clinically for delirium‐related symptoms, its effects on subsequent cognition remain unclear.
Hideki Matsuoka, Leo Gotoh, Hikaru Hori
wiley   +1 more source

Limited Agreement Between Perceptual and Physiological Heat Strain at Initial Stay Times for Continuous Work in the Heat Before Heat Alleviation Controls

American Journal of Industrial Medicine, Volume 69, Issue 11, Page 972-983, November 2026.
ABSTRACT Introduction Accurate assessment of heat strain at initial stay time (IST; core temperature 38.0°C or Δ1.0°C above resting), when heat mitigation decisions are required, is critical for managing occupational heat exposure. We evaluated the relationship and agreement between physiological (Physiological Strain Index [PSI] and adaptive PSI [aPSI]
Gil Bourgois, Kristina‐Marie T. Janetos, Fergus K. O'Connor, Leonidas G. Ioannou, Glen P. Kenny   +4 more
wiley   +1 more source