Results 111 to 120 of about 12,153 (246)

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

Mendelianization: Concentrating Polygenic Signal Into a Single Causal Locus

Genetic Epidemiology, Volume 50, Issue 6, September 2026.
ABSTRACT Complex disorders such as depression and alcohol use involve numerous genetic variants, and implicated loci continue to grow with sample size. This proliferation hampers interpretability, as the mechanisms by which so many variants jointly contribute to pathophysiology remain unclear.
Eric V. Strobl
wiley   +1 more source

Processed EEG Monitoring During Pediatric Procedural Sedation: Correlation Between the Narcotrend Index and the Pediatric Sedation State Scale

Pediatric Anesthesia, Volume 36, Issue 9, Page 1126-1131, September 2026.
ABSTRACT Background Objective assessment of sedation depth in children undergoing procedural sedation while maintaining spontaneous breathing and protective reflexes can be challenging. Processed electroencephalogram (pEEG) monitoring systems such as the Narcotrend monitor may provide continuous information regarding the depth of sedation.
Hendryk Schneider, Daniel Matheisl, Martin Kuntz, Hans Fuchs   +3 more
wiley   +1 more source

Nationwide expansion of the EGUIDE project in Japan: A nine‐year overview

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim This study aimed to describe the nationwide reach, longitudinal growth, and geographic dissemination of the Effectiveness of Guideline for Dissemination and Education in Psychiatric Treatment (EGUIDE) project in Japan from 2016 to 2024. Methods The EGUIDE project is a nationwide, multicenter implementation initiative designed to promote ...
Hiroyuki Muraoka, Keisuke Mori, Takashi Tsuboi, Hitoshi Iida, Kentaro Fukumoto, Kazutaka Ohi, Kayo Ichihashi, Jun‐ichi Iga, Yuka Yasuda, Toshinori Nakamura, Eiichi Katsumoto, Tatsuya Nagasawa, Shusuke Numata, Shinichiro Ochi, Hirotaka Yamagata, Tomoyasu Wakuda, Masahiro Takeshima, Fumitoshi Kodaka, Yasushi Kawamata, Toru Horinouchi, Kazuhiko Yamamuro, Yusuke Arai, Satsuki Ito, Junya Matsumoto, Hisashi Yamada, Hikaru Hori, Ken Inada, Koichiro Watanabe, Norio Yasui‐Furukori, Ryota Hashimoto   +29 more
wiley   +1 more source

An open‐label, long‐term extension, multicenter study to evaluate the safety and efficacy of venlafaxine extended release in Japanese outpatients with generalized anxiety disorder

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim This study evaluated the long‐term safety and efficacy of venlafaxine extended release (ER), which has been administered for 52 weeks in Japanese adult outpatients with generalized anxiety disorder (GAD). Methods In this open‐label, long‐term extension, multicenter study, 135 Japanese patients with GAD were enrolled after completing 10 ...
Tempei Otsubo, Koichiro Watanabe, Takeshi Inoue, Ataru Inagaki, Toshiaki Kikuchi, Keisuke Nomoto, Shingo Higa, Yuko Asami, Bin Sun, Kristina Marschall   +9 more
wiley   +1 more source

Clinical characteristics and risk factors associated with consultation‐confirmed delirium in hospitalized patients

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim Delirium, a serious neuropsychiatric hospitalization complication, is a manifestation of underlying neurocognitive vulnerability rather than an acute event. In Japan, a nationwide medical policy mandates early hospital‐wide delirium risk screening to evaluate predefined risk factors in inpatient populations.
Megumi Matsuda, Kazuhiko Yamamuro, Masatsugu Ikeuchi, Akihiro Minami, Izumi Harada, Takahira Yamauchi, Tetsuro Kitamura, Yasuyo Kobayashi, Yukako Ishida, Yusuke Inagaki, Jyunko Minamiguchi, Akira Kido, Takashi Okada   +12 more
wiley   +1 more source

Central Nervous System (CNS) Medication Use Before Suicide Among Older Adults in Sweden From 2007 to 2020: A Register-Based Case-Control Study. [PDF]

Int J Geriatr Psychiatry
Miao TT, Szilcz M, Chang Z, Wastesson JW, Johnell K.   +4 more
europepmc   +1 more source

Efficacy and safety of traditional Chinese medicine aromatherapy for insomnia patients with predominant difficulty in sleep initiation

Sleep Research, Volume 3, Issue 3, Page 258-271, September 2026.
Abstract Background Insomnia is highly prevalent, and non‐pharmacological strategies to facilitate sleep initiation remain an important clinical priority. Aims This study aimed to evaluate the tolerability, safety, and preliminary sleep‐related effects of a herbal aromatherapy liquid administered using a Traditional Chinese Medicine Aromatherapy Sleep ...
Huafeng Shan, Chun Wang, Dengyi Cao, Yi Long, Xiaowei Huang, Jiayang Meng, Zhongxia Shen, Xiaomei Zhang, Qinjuan Ren   +8 more
wiley   +1 more source

Obstructive sleep apnea-hypopnea syndrome induced by dexmedetomidine in a patient with long-term sedatives: A case report. [PDF]

Medicine (Baltimore)
Feng Q, Yin H.
europepmc   +1 more source

Prevalence of Benzodiazepine, Z‐Drug and Melatonin Use in Australian Residential Aged Care Facilities: A Systematic Review and Meta‐Analysis

Australasian Journal on Ageing, Volume 45, Issue 3, September 2026.
ABSTRACT Objectives To systematically examine the prevalence of, and factors associated with, benzodiazepine, Z‐drug and melatonin use in Australian residential aged care facilities (RACFs). Methods MEDLINE, Embase, CINAHL, PsycINFO, Scopus and International Pharmaceutical Abstracts were searched from January 2000 to February 2025 for studies reporting
Yuxing Joyce Liu, J. Simon Bell, Annie M. L. Ea, Mingxuan Cui, Ho Chan, Faiza Hoda, Amanda J. Cross   +6 more
wiley   +1 more source