Results 181 to 190 of about 2,520,373 (232)
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Modification of phosphatidylserine by hypochlorous acid
Chemistry and Physics of Lipids, 2009The binding of the heme enzyme myeloperoxidase to phosphatidylserine epitopes on the surface of non-vital polymorphonuclear leukocytes and other cells at inflammatory sites favours modifications of this phospholipid by myeloperoxidase products. As detected by MALDI-TOF mass spectrometry hypochlorous acid and the myeloperoxidase-hydrogen peroxide ...
Joerg, Flemmig +4 more
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Cephalosporins are scavengers of hypochlorous acid
Biochemical Pharmacology, 1995Potential scavenging properties of cephalosporins (i.e. cefamandole, cefotaxime and ceftriaxone) towards hypochlorous acid (HOCl) as well as the antibacterial activity of control and HOCl-reacted antibiotics were investigated. We found that these drugs, at therapeutically relevant concentrations, are indeed scavengers of HOCl, with ceftriaxone showing ...
LAPENNA, Domenico +6 more
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Biomarkers of myeloperoxidase-derived hypochlorous acid
Free Radical Biology and Medicine, 2000Hypochlorous acid is the major strong oxidant generated by neutrophils. The heme enzyme myeloperoxidase catalyzes the production of hypochlorous acid from hydrogen peroxide and chloride. Although myeloperoxidase has been implicated in the tissue damage that occurs in numerous diseases that involve inflammatory cells, it has proven difficult to ...
C C, Winterbourn, A J, Kettle
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Ambroxol Is a Scavenger of Hypochlorous Acid and Monochloramine
Pharmacology, 2008Experimental studies have suggested that ambroxol, a drug clinically used to enhance pulmonary surfactant production, may also exert some anti-inflammatory effects, though specific mechanisms are not yet fully understood. Thus, potential scavenging properties of ambroxol towards the most toxic neutrophil-arising prooxidants hypochlorous acid and ...
LAPENNA, Domenico +3 more
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Hypochlorous Acid Is a Potent Inhibitor of Acetylcholinesterase
Toxicology and Applied Pharmacology, 2002The role of hydrogen peroxide and peroxynitrite in the induction of airway hyperreactivity has been well described. Another reactive species which is formed during airway inflammation is hypochlorous acid (HOCl). In the present investigation the effect of HOCl on cholinergic innervation of the airway was investigated.
den Hartog, G.J.M. +4 more
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Reaction of NO with hypochlorous acid
International Journal of Chemical Kinetics, 1979AbstractThe reaction between NO(g) at concentrations between 0.1 and 1.0 Torr in 1‐atm N2 and aqueous solutions of NaClO has been studied over the pH range of 6–12 and hypochlorite concentrations between 0.01 and 1.0M. A very rapid and efficient reaction occurs leading to the production of about 30%–40% of the NO as NO2 and with conversions of NO up to
Elena Ghibaudi +2 more
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A spectroscopic probe for hypochlorous acid detection
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022A spectroscopic probe CMBT was synthesized and characterized. CMBT showed the specific recognition for HClO based on the turn-on blue fluorescence and naked-eye change from pink to colorless. NMR, IR, HRMS-ESI, and spectral analysis suggested that colorimetric and fluorescent change of CMBT to HClO originated from the conversion of CMBT to starting ...
Ning, An +3 more
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Wound cleansing: benefits of hypochlorous acid
Journal of Wound Care, 2020Cleansing provides an opportunity to remove pathogens from the wound bed, thereby preventing an increase in the bioburden and delayed healing.
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Chlorogenic Acid as a Natural Scavenger for Hypochlorous Acid
Biochemical and Biophysical Research Communications, 1995The effect of chlorogenic acid (CGA) on the killing of Escherichia coli by hypochlorous acid (HOCI) was examined. CGA prevented E. coli from bactericidal action of HOCI in a concentration-dependent manner. HOCI reacted rapidly with CGA. By comparison with the one- and two-electron oxidation products produced by peroxidase and phenolase reactions ...
Y, Kono +4 more
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Reaction of γ‐Tocopherol with Hypochlorous Acid
Lipids, 2007AbstractIn addition to being a very good antioxidant, γ‐tocopherol is also an excellent electrophile trap. This is a study of the reactivity of γ‐tocopherol with hypochlorous acid/hypochlorite, a potential biological foe that is both an oxidant and an electrophile. Aqueous sodium hypochlorite (1.72 mmol; pH 7.4) was stirred with γ‐tocopherol (0.12 mmol)
Quyen, Nguyen, Peter T, Southwell-Keely
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