Results 181 to 190 of about 26,374 (235)
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Scavenging of hypochlorous acid by lipoic acid
Biochemical Pharmacology, 1991Guido R M M Haenen, Aalt Bast
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Reaction of uracil with hypochlorous acid
Biochemical and Biophysical Research Communications, 1978Abstract The end products of the reaction of uracil with at least a 10-fold excess of aqueous hypochlorous acid at pH 7–8 were found to be trichloroacetic acid, carbon dioxide and nitrogen trichloride. Little formation of trichloroacetic acid was observed after 24 hours when the ratio of hypochlorous acid to uracil was less than 4:1.
W H, Dennis, V P, Olivieri, C W, Krusé
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Modification of phosphatidylserine by hypochlorous acid
Chemistry and Physics of Lipids, 2009The binding of the heme enzyme myeloperoxidase to phosphatidylserine epitopes on the surface of non-vital polymorphonuclear leukocytes and other cells at inflammatory sites favours modifications of this phospholipid by myeloperoxidase products. As detected by MALDI-TOF mass spectrometry hypochlorous acid and the myeloperoxidase-hydrogen peroxide ...
Joerg, Flemmig +4 more
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Cephalosporins are scavengers of hypochlorous acid
Biochemical Pharmacology, 1995Potential scavenging properties of cephalosporins (i.e. cefamandole, cefotaxime and ceftriaxone) towards hypochlorous acid (HOCl) as well as the antibacterial activity of control and HOCl-reacted antibiotics were investigated. We found that these drugs, at therapeutically relevant concentrations, are indeed scavengers of HOCl, with ceftriaxone showing ...
LAPENNA, Domenico +6 more
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Mechanism of cyanocobalamin chlorination by hypochlorous acid
JBIC Journal of Biological Inorganic Chemistry, 2021Hypochlorous acid (HOCl) is a strong oxidant produced by myeloperoxidase. Previous work suggested that HOCl modifies the corrin ring of cobalamins to yield chlorinated species via mechanisms that are incompletely understood. Herein, we report a mechanistic study on the reaction between cyanocobalamin (CNCbl, vitamin B12) and HOCl.
Ilia A. Dereven’kov +5 more
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Biomarkers of myeloperoxidase-derived hypochlorous acid
Free Radical Biology and Medicine, 2000Hypochlorous acid is the major strong oxidant generated by neutrophils. The heme enzyme myeloperoxidase catalyzes the production of hypochlorous acid from hydrogen peroxide and chloride. Although myeloperoxidase has been implicated in the tissue damage that occurs in numerous diseases that involve inflammatory cells, it has proven difficult to ...
C C, Winterbourn, A J, Kettle
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A spectroscopic probe for hypochlorous acid detection
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022A spectroscopic probe CMBT was synthesized and characterized. CMBT showed the specific recognition for HClO based on the turn-on blue fluorescence and naked-eye change from pink to colorless. NMR, IR, HRMS-ESI, and spectral analysis suggested that colorimetric and fluorescent change of CMBT to HClO originated from the conversion of CMBT to starting ...
Ning, An +3 more
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Ambroxol Is a Scavenger of Hypochlorous Acid and Monochloramine
Pharmacology, 1994Experimental studies have suggested that ambroxol, a drug clinically used to enhance pulmonary surfactant production, may also exert some anti-inflammatory effects, though specific mechanisms are not yet fully understood. Thus, potential scavenging properties of ambroxol towards the most toxic neutrophil-arising prooxidants hypochlorous acid and ...
LAPENNA, Domenico +3 more
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Reaction of NO with hypochlorous acid
International Journal of Chemical Kinetics, 1979AbstractThe reaction between NO(g) at concentrations between 0.1 and 1.0 Torr in 1‐atm N2 and aqueous solutions of NaClO has been studied over the pH range of 6–12 and hypochlorite concentrations between 0.01 and 1.0M. A very rapid and efficient reaction occurs leading to the production of about 30%–40% of the NO as NO2 and with conversions of NO up to
Elena Ghibaudi +2 more
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