Results 141 to 150 of about 113,928,997 (189)

Spectroscopic studies on the interaction of hypocrellin A and hemoglobin

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2009
The spectrophotometric and spectrofluorimetric studies revealed that hemoglobin (Hb) could interact with hypocrellin A, a photosensitizing drug used in photodynamic therapy. It was found that this kind of interaction can induce the conformational changes in Hb.
Xiaohong Wu, Wei Shaohua, Jiahong Zhou   +2 more
exaly   +3 more sources

Potentiation of hypericin and hypocrellin-induced phototoxicity by omeprazole

Phytomedicine, 1999
Hypericin and hypocrellin are potential antiviral and antineoplastic agents with multiple modes of light-induced biological activity connected with a production of singlet oxygen and/or excited-state proton transfer and consequent pH drop formation in the drugs environment.
Pavol Miskovsky, Jan Mojžiš, Jana Tóthová   +2 more
exaly   +3 more sources

Photoreactions of hypocrellin B with thiol compounds

Journal of Photochemistry and Photobiology B: Biology, 1998
Abstract The photoreactions of hypocrellin B (HB) with thiol compounds (RSH) in ethanol buffer solutions have been investigated by electron spin resonance (ESR), α-phenyl-N-tert-butyl nitrone (PBN) spin trapping and quenching experiments. The mechanism of photothiylation of HB is proposed to involve a nucleophilic anion (RS−) addition of Michael type
Yu-Ying He, Jing-Yi An, Li-Jin Jiang
exaly   +2 more sources

Biotechnological production and potential applications of hypocrellins

Applied Microbiology and Biotechnology, 2023
Hypocrellins (HYPs), a kind of natural perylenequinones (PQs) with an oxidized pentacyclic core, are important natural compounds initially extracted from the stromata of Hypocrella bambusae and Shiraia bambusicola. They have been widely concerned for their use as anti-microbial, anti-cancers, and anti-viral photodynamic therapy agents in recent years ...
Zhuanying Bao, Yunchang Xie, Chenglong Xu, Zhibin Zhang, Du Zhu   +4 more
openaire   +2 more sources

Comparing the interaction of vanadyl-hypocrellin A complex and hypocrellin A with CT DNA

Journal of Molecular Structure, 2013
Abstract Interaction studies of the vanadyl-hypocrellin A (VO 2+ -HA) complex and hypocrellin A (HA) with CT DNA were investigated by UV–Vis spectroscopy, DNA melting, fluorescence spectra and zeta potential measurements. The binding constants and binding mechanisms of HA and VO 2+ -HA with CT DNA had also been studied by fluorescence quenching ...
Chao Yang, Fei Ma, Jing Tang, Lina Han, Shaohua Wei, Lin Zhou, Jiahong Zhou, Jian Shen, Xuefeng Ge   +8 more
openaire   +1 more source

Photoinactivation of Virus Infectivity by Hypocrellin A

Photochemistry and Photobiology, 1997
Abstract— We investigated the photoinactivation of virus infectivity by hypocrellin A and its mechanism. The titers of vesicular stomatitis virus (VSV) and human immunodeficiency virus type 1 (HIV‐1), both of which are enveloped viruses, were reduced upon illumination with hypocrellin A in a concentration‐dependent manner, whereas canine parvovirus, a ...
J, Hirayama, K, Ikebuchi, H, Abe, K W, Kwon, Y, Ohnishi, M, Horiuchi, M, Shinagawa, K, Ikuta, N, Kamo, S, Sekiguchi   +9 more
openaire   +2 more sources

Efficacy of hypocrellin pharmacokinetics in phototherapy

International Journal of Oncology, 2002
Hypocrellins A and B are pigments which are isolated from the parasitic fungi Hypocrella bambuase sacc and Shiraia bambusicola P. Heen found in the People's Republic of China and other parts of Asia including Sri Lanka. These agents, which belong to the general class of perylene quinonoid pigments, have a long history of traditional medicinal agents ...
Seyed Mohamed, Ali, Malini, Olivo
openaire   +2 more sources

Electrochemical study of Hypocrellin B in acetonitrile and aqueous micellar media. Comparison with Hypocrellin A

New Journal of Chemistry, 2004
The electrochemical behaviour of Hypocrellin B (HBH2) has been investigated in acetonitrile and in aqueous micellar media. In organic medium, HBH2 behaves similarly to Hypocrellin A (HAH2) since two successive reversible one-electron transfers are observed in the cathodic region.
Stephane Dumas, Pierre Jardon, Jean-Claude Lepretre, Andr� Jeunet   +3 more
openaire   +2 more sources

HYPOCRELLIN‐A SENSITIZED PHOTOOXIDATION OF BILIRUBIN

Photochemistry and Photobiology, 1989
Abstract— Hypocrellin A (HA) extracted from Hypocrellia batnbusae (b.et Br.) sace, a derivative of 3,10‐dihydroxy‐4,9‐perylenequinone, is a highly effective photosensitizer. Kinetic studies of the HA‐sensitized photooxidation of bilirubin IXα (BR) in different solvents in the presence of various active oxygen quenchers indicate that in aprotic solvents
J S, Ma, F, Yan, C Q, Wang, J Y, An
openaire   +2 more sources

Photobleaching of Hypocrellin B and 2‐Taurine Substituted Hypocrellin B in Plasma Solution

Chinese Journal of Chemistry, 2008
AbstractPhotodynamic therapy (PDT) is a new methodology to utilize jointly a photosensitizer and light to destroy the target tissues of diseases via some photochemical reactions. On the other hand, the photosensitizer molecules may also be photo‐bleached during PDT, furthermore, their interaction with biomolecules and the photobleaching properties in ...
Hui‐Ying DING, Yang ZHANG, Ying GU, Jing‐Quan ZHAO   +3 more
openaire   +1 more source