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The Journal of Physical Chemistry B, 1998
The photophysics of hypocrellin is examined by means of transient absorption spectroscopy. On the shortest time scale investigated, an ∼10 ps component is observed in the isotropic (“magic angle”) transient absorption, ΔA(t), and in the anisotropy decay, r(t), for hypocrellin in viscous solvents such as octanol and ethylene glycol.
K. Das +3 more
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The photophysics of hypocrellin is examined by means of transient absorption spectroscopy. On the shortest time scale investigated, an ∼10 ps component is observed in the isotropic (“magic angle”) transient absorption, ΔA(t), and in the anisotropy decay, r(t), for hypocrellin in viscous solvents such as octanol and ethylene glycol.
K. Das +3 more
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Quenching of fluorescence in membrane protein by hypocrellin B
Science in China Series C: Life Sciences, 1997The hypocrellin B (HB) was used as a fluorescence quencher to study the basic physical charactcristics of HB in membrane systems, including the diffusion speed of quencher from aqueous phase into membrane phase, the partition coefficient (P) of quenchtr between membrane and water, and the fluorescence quenching constant of protein (K(sv); K(q),).
J, Yue, S, Pang
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Potentiation of hypericin and hypocrellin-induced phototoxicity by omeprazole
Phytomedicine, 1999Hypericin and hypocrellin are potential antiviral and antineoplastic agents with multiple modes of light-induced biological activity connected with a production of singlet oxygen and/or excited-state proton transfer and consequent pH drop formation in the drugs environment.
A, Mirossay +5 more
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Photochemistry of hypocrellin A (IV)--Hypocrellin A-sensitized photooxidation of diphenylamine.
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences, 1988The photooxidation of diphenylamine is acetonitrile and methanol using Hypocrellin A as sensitizer will be reported in this paper. The products in the two solvents were isolated and identified. The reaction mechanisms were investigated. In acetonitrile, diphenylamine was oxidized by singlet oxygen to form N-phenyl-p-benzoquinonimine.
J N, Ma, M H, Zhang, J Y, An, L J, Jiang
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Spectroscopic studies on the interaction of Ga3+-hypocrellin A with myoglobin
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014In this article, the interaction mechanism of Ga(3+)-hypocrellin A (Ga(3+)-HA) with myoglobin (Mb) is studied in detail through various spectroscopic technologies. UV-vis absorption and fluorescence spectra demonstrate the interaction process. The Stern-Volmer plot and the time-resolved fluorescence study suggest the fluorescence quenching mechanism of
Wenli, Xie +6 more
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Antibacterial activity of hypocrellin A against Staphylococcus aureus
World Journal of Microbiology and Biotechnology, 2012The antibacterial activity and acting mechanism of hypocrellin A (HA) were conducted regarding in vitro activity of HA on Staphylococcus aureus GZ86 by analyzing the growth, permeability, and morphology of the bacterial cells following treatment with HA. The experimental results indicated 1.5 mg/l HA could completely inhibit the growth of 10⁷ CFU/ml S.
Wen, Du +4 more
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Prediction on amphiphilicity of hypocrellin derivatives
Science in China Series B, 2002Hypocrellins are most suitable for photodynamic therapy (PDT) of the diseases occurring in the superficial layer, such as microvascular diseases, because of their special absorption spectral properties. However, hypocrellins and most of their derivatives are basically lipophilic, while the hydrophilic derivatives lose the PDT activity in vivo ...
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The Role of Oxygen in the Antiviral Activity of Hypericin and Hypocrellin
Photochemistry and Photobiology, 1998AbstractThe light‐induced antiviral activity of hypericin and hypocrellin in the presence and absence of oxygen was examined under experimental conditions where the effect of oxygen depletion could be quantified. There was a significant reduction of light‐induced antiviral activity of hypericin and hypocrellin under hypoxic conditions.
J, Park +4 more
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Photo-induced interactions of hypocrellin A with phycobiliproteins
Research on Chemical Intermediates, 2004Photo-induced interaction of hypocrellin A (HA) with a water-soluble protein (C-phycocyanin, C-PC) was studied by monitoring the changes of the photo-physical properties of C-PC, as well as those of HA. It was found that the solubility of HA in phosphate-buffered saline solution was greatly promoted in the presence of C-PC. Furthermore, energy transfer
Baozhong Zhao, Jie Xie, Jingquan Zhao
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