Photodynamic Action of Hypocrellin A and Hypocrellin B against Cancer—A Review [PDF]
PharmaceuticalsCancer is a major global health concern, affecting nearly 20 million individuals annually, according to the International Agency for Research on Cancer (IARC). There are some unconventional and conventional treatments for cancer.
Jinju Huang +3 more
doaj +5 more sources
Volatiles of Shiraia fruiting body-associated Pseudomonas putida No.24 stimulate fungal hypocrellin production [PDF]
Synthetic and Systems Biotechnology, 2023 Hypocrellins are major bioactive perylenequinones from Shiraia fruiting bodies and have been developed as efficient photosensitizers for photodynamic therapy.
Rui Xu +5 more
doaj +3 more sources
Interdisciplinary MedicinePhotodynamic and photothermal therapy have emerged as standard treatments for a range of tumors and microvascular diseases. However, a significant gap remains in the clinical availability of photosensitizers.
exaly +3 more sources
Surface modification and nanodelivery of hypocrellin-based photosensitizers: photophysical optimization and biomedical applications [PDF]
Journal of NanobiotechnologyPhotodynamic therapy (PDT) has emerged as an advanced therapeutic modality owing to its inherent merits of minimal invasiveness and precise spatiotemporal control.
Xingzhe Wang +6 more
doaj +2 more sources
Natural Photosensitizers in Cancer Therapy: A Chemo-Biodiversity Perspective on Light-Activated Natural Compounds. [PDF]
Chem BiodiversNatural photosensitizers, shaped by chemo‐biodiversity and evolution, offer diverse photoactive scaffolds for PDT. This review highlights their structure–activity relationships, photophysical properties, and nanotechnology‐based strategies to enhance efficacy, while addressing translational challenges and demonstrating how nature's molecular diversity ...
Baidoo I, Abrahamse H, George BP.
europepmc +2 more sources
Mitochondrial genome and transcription of Shiraia-like species reveal evolutionary aspects in protein-coding genes [PDF]
IMA FungusShiraia-related species are well-known bambusicolous fungi in Dothideomycetes class, with high value in traditional medicine for producing hypocrellin, as an anticipated photosensitiser.
Xiao-Ye Shen +6 more
doaj +4 more sources
Spermidine stimulates hypocrellin A biosynthesis through nitric oxide signaling in Shiraia sp. S9 [PDF]
Bioresources and BioprocessingHypocrellin A (HA), a photoactive perylenequinone from the bambusicolous Shiraia fungi, possesses potent photodynamic anticancer and antimicrobial properties. However, the signaling mechanisms governing its biosynthesis remain poorly understood.
Li Ping Zheng +4 more
doaj +2 more sources
Enhancement of Perylenequinonoid Compounds Production from Strain of Pseudoshiraia conidialis by UV-Induced Mutagenesis [PDF]
MicroorganismsPerylenequinonoid compounds, represented by photosensitive therapeutic agents such as hypocrellins and elsinochromes, demonstrate extensive potential across biomedical, agricultural, and food industrial applications.
Xin Tong +3 more
doaj +2 more sources
Optimisation of hypocrellin production in Shiraia-like fungi via genetic modification involving a transcription factor gene and a putative monooxygenase gene [PDF]
MycologyShiraia-like fungi, which are rare parasitic fungi found around bamboo, play an important role in traditional medicine. Their main active component, hypocrellin, is widely used in medicine, food, and cosmetics.
Zi-Min Lu +6 more
doaj +2 more sources
Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications [PDF]
International Journal of NanomedicineSheeja S Rajan, Rahul Chandran, Heidi Abrahamse Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South AfricaCorrespondence: Sheeja S Rajan; Heidi Abrahamse, Laser Research Centre, Faculty of Health Sciences ...
Rajan SS, Chandran R, Abrahamse H
doaj +2 more sources