Results 31 to 40 of about 113,928,997 (189)
Acta Pharmaceutica Sinica B, 2019 Over recent decades, many studies have reported that hypocrellin A (HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defined.
Shanshan Qi +5 more
doaj +2 more sources
Phylogenetic Position of Shiraia-Like Endophytes on Bamboos and the Diverse Biosynthesis of Hypocrellin and Hypocrellin Derivatives [PDF]
Journal of Fungi, 2021 The main active ingredients of the fruiting bodies of Shiraia bambusicola and Rubroshiraia bambusae are Hypocrellins, belonging perylenequinones with potential photodynamic activity against cancer and microbial diseases. However, the strains of S. bambusicola and R.
Xin Tong +4 more
openaire +3 more sources
HYPOCRELLINS and THEIR USE IN PHOTOSENSITIZATION* [PDF]
Photochemistry and Photobiology, 1990 Abstract— Hypocrellins A and B are pigments which are isolated from parasitic fungi Hypocrella bambuase (B. et Br) sacc. and Shiraia bambusicola P. Heen found in the People's Republic of China (P.R.C.) and Sri Lanka respectively. These agents, which belong to the general class of perylene quinonoid pigments, have a long history as traditional medicinal
D, Zhenjun, J W, Lown
openaire +2 more sources
Pharmacological Research, 2022 Lung adenocarcinoma (LUAD) is associated with poor prognosis. Identifying novel cancer targets and helpful therapeutic strategies remains a serious clinical challenge.
Xiaona Xie +14 more
doaj +1 more source
Perylenequinone Natural Products: Total Synthesis of Hypocrellin A
, 2016 An efficient and stereoselective total synthesis of the perylenequinone natural product hypocrellin A (1) is described. The key features include a potentially biomimetic 1,8-diketone aldol cyclization to set the centrochiral C7,C7′-stereochemistry, bis ...
Erin M. O’Brien (2328625) +4 more
core +4 more sources
Antimicrobial and Antileishmanial Activities of Hypocrellins A and B [PDF]
Antimicrobial Agents and Chemotherapy, 2004 ABSTRACT Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus , methicillin-resistant S. aureus ,
Guoyi, Ma +7 more
openaire +2 more sources
Scientific Reports, 2021 Shiraia bambusicola has been used as a traditional Chinese medicine for a long history. Its major medicinal active metabolites are perylenequinones, including hypocrellin A, elsinochrome A and so on. At present, the fermentation yield of perylenequinones
Ning Zhao +6 more
doaj +1 more source
Adaptive Responses to Oxidative Stress in the Filamentous Fungal Shiraia bambusicola
Molecules, 2016 Shiraia bambusicola can retain excellent physiological activity when challenged with maximal photo-activated hypocrellin, which causes cellular oxidative stress.
Huaxiang Deng +4 more
doaj +1 more source
Microbial Cell Factories, 2021 Background Nitric oxide (NO) is a ubiquitous signaling mediator in various physiological processes. However, there are less reports concerning the effects of NO on fungal secondary metabolites.
Yan Jun Ma +3 more
doaj +1 more source
Response mechanism of hypocrellin colorants biosynthesis by Shiraia bambusicola to elicitor PB90
AMB Express, 2019 The valuable medicine Shiraia bambusicola P. Henn. and its major active substance hypocrellin exert unique curative effects on skin diseases, diabetes, and cancers. The wild S.
Wen Du +11 more
doaj +1 more source