Results 71 to 80 of about 76,609 (311)

Impaired hypoglycaemia awareness in type 1 diabetes:lessons from the lab [PDF]

, 2018
Hypoglycaemia remains the most common metabolic adverse effect of insulin and sulfonylurea therapy in diabetes. Repeated exposure to hypoglycaemia leads to a change in the symptom complex that characterises hypoglycaemia, culminating in a clinical ...
A Moheet, AC Hauge-Evans, AD McNeilly, AD McNeilly, Alison D. McNeilly, BM Frier, C Beall, C Fanelli, CH Rankin, EC Puente, G Öz, HM Rooijackers, I Cranston, I Quesada, J Geddes, J Lawton, JE Gerich, JE Schopman, JJ Winnick, L Briant, L Jacobson, L Jiang, M Mikeladze, M Mokan, MA Osundiji, MR Davis, MS Hedrington, NH White, O Chan, PG Henry, PJ Boyle, PS George, Q Tong, RD Belfort-DeAguiar, RF Thompson, RJ McCrimmon, RJ McCrimmon, RJ McCrimmon, RJ McCrimmon, Rory J. McCrimmon, S Vele, SA Amiel, SA Segel, SN Davis, SR Heller, V McAulay, WA Muller   +46 more
core   +3 more sources

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, EarlyView.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

Fear of hypoglycaemia: defining a minimum clinically important difference in patients with type 2 diabetes

Health and Quality of Life Outcomes, 2009
Background To explore the concept of the Minimum Clinically Important Difference (MID) of the Worry Scale of the Hypoglycaemia Fear Survey (HFS-II) and to quantify the clinical importance of different types of patient-reported hypoglycaemia.
Gonder-Frederick Linda, Stargardt Tom, Krobot Karl J, Alexander Charles M   +3 more
doaj   +1 more source

Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations [PDF]

, 2009
Background: Activating mutations in the GLUD1 gene (which encodes for the intra-mitochondrial enzyme glutamate dehydrogenase, GDH) cause the hyperinsulinism–hyperammonaemia (HI/HA) syndrome.
Banerjee, I., Ben-Omran, T., Chadefaux, B., Chakrapani, A., Ellard, S., Flanagan, S. E, Fulton, P., Hussain, K., Kapoor, R. R, Shield, J. P   +9 more
core   +2 more sources

Poria cocos as a Functional Food for Diabetes and Diabetes‐Related Foot Ulcers

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Poria cocos is known as an edible mushroom for food and medicine. Poria cocos and its terpenes and terpenoids serve as novel remedies to treat diabetes and its ulcers. Its mode of actions includes reduction of insulin resistance, starch digestion and inflammation as well as promotion of blood vessel formation. ABSTRACT Poria cocos is a medicinal fungus
Yi‐San Lee, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +3 more
wiley   +1 more source

Syndrome of the Month: An Update on Smith‐Kingsmore Syndrome: Characterization of Developmental Milestones and a Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith‐Kingsmore syndrome (SKS) is a rare autosomal dominant condition characterized by neurodevelopmental differences, macrocephaly/megalencephaly, describable facial features, sleep–wake abnormalities, hyperphagia, and overgrowth. SKS is caused by pathogenic gain‐of‐function variants in MTOR which lead to hyperactivation of the mTOR pathway ...
Carolyn R. Raski, Carlos E. Prada
wiley   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

A prospective randomised cross-over study of the effect of insulin analogues and human insulin on the frequency of severe hypoglycaemia in patients with type 1 diabetes and recurrent hypoglycaemia (the HypoAna trial): study rationale and design

BMC Endocrine Disorders, 2012
Background Severe hypoglycaemia still represents a significant problem in insulin-treated diabetes. Most patients do not experience severe hypoglycaemia often.
Kristensen Peter, Pedersen-Bjergaard Ulrik, Beck-Nielsen Henning, Nørgaard Kirsten, Perrild Hans, Christiansen Jens, Jensen Tonny, Parving Hans-Henrik, Thorsteinsson Birger, Tarnow Lise   +9 more
doaj   +1 more source

Characteristics and costs of individuals experiencing severe hypoglycaemia requiring emergency ambulance assistance in the community [PDF]

, 2012
Background and aims: Hypoglycaemia causes considerable a burden to individuals the healthcare providers. The aim of this study was to examine clinical characteristics of individuals requiring emergency medical assistance by ambulance services for an ...
Davies, Melanie J., Fisher, Harriet, Iqbal, Mohammad, Khunti, Kamlesh, Paul, Sanjoy, Siriwardena, A. Niroshan   +5 more
core   +1 more source

Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats

Animal Models and Experimental Medicine, EarlyView.
The experimental type 2 diabetes model in rats induced by streptozotocin and nicotinamide showed that silver nanoparticles synthesized from lemongrass extract modulate blood glucose, water and food intake, and enhance antioxidant enzyme synthesis and weight gains.
Milad Faraji, Mohammad Foad Noorbakhsh, Nasrin Kazemipour, Saeed Nazifi, Hamid Reza Moradi, Nasrollah Ahmadi, Maryam Azadmanesh   +6 more
wiley   +1 more source