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Theophylline Improves Hypoglycemia Unawareness in Type 1 Diabetes [PDF]
Diabetes, 2002 Iatrogenic hypoglycemias and the subsequent occurrence of hypoglycemia unawareness are well-known complications of intensive insulin therapy in type 1 diabetic patients that limit glycemic management. From a pharmacological point of view, the adenosine-receptor antagonist theophylline might be beneficial in the management of hypoglycemia unawareness ...
Bastiaan E de Galan +2 more
exaly +5 more sources
Current Diabetes Reports, 2018 In addition to assisting in achieving improved glucose control, continuous glucose monitoring (CGM) sensor technology may also aid in detection and prevention of hypoglycemia. In this paper, we report on the current scientific evidence on the effectiveness of this technology in the prevention of severe hypoglycemia and hypoglycemia unawareness.Recent ...
Carmine Giuseppe Fanelli +2 more
exaly +5 more sources
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Induction of Hypoglycemia Unawareness by Asymptomatic Nocturnal Hypoglycemia
Diabetes, 1993Hypoglycemia has been incriminated as a possible factor responsible for development of the hypoglycemia unawareness phenomenon in patients with type I diabetes. Many patients with this condition, however, do not have a history of recent hypoglycemia.
Marian Mokan, J Gerich, T Veneman
exaly +3 more sources
Hypoglycemia Unawareness in IDDM
Diabetes Care, 1993Hypoglycemia unawareness—loss of the neurogenic (autonomic) warning symptoms of developing hypoglycemia—is one of three hypoglycemia-associated clinical syndromes that exemplify hypoglycemia-associated autonomic failure in IDDM. Reduced awareness of developing hypoglycemia (an elevated glycemic threshold for symptoms) is a feature not only of ...
Philip E. Cryer, P E Cryer
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New England Journal of Medicine, 1995
The article by Boyle et al.1 in this issue of the Journal indicates that accelerated transport of glucose to the brain is a possible mechanism of unawareness of hypoglycemia on the part of patients...
Carmine Giuseppe Fanelli +1 more
exaly +3 more sources
The article by Boyle et al.1 in this issue of the Journal indicates that accelerated transport of glucose to the brain is a possible mechanism of unawareness of hypoglycemia on the part of patients...
Carmine Giuseppe Fanelli +1 more
exaly +3 more sources
Diabetes Care, 2009 OBJECTIVE - Hypoglycemia unawareness increases severe hypoglycemia risk. Hypoglycemia avoidance restores awareness, but it is difficult to sustain. We compared adherence to treatment changes by awareness status.
Pratik Choudhary +2 more
exaly +2 more sources
A potential role for GPR107 in hypoglycemia unawareness
Physiology, 2023Hypoglycemia unawareness (HU) is a major barrier to achieving glycemic control in diabetic patients and remains a severe complication for type 1 and many type 2 diabetics. Due to the limited availability of animal models and significant variations between existing models, our understanding is limited regarding the cellular mechanisms and neural ...
Lisa Hagena +4 more
openaire +1 more source
Diabetes Research and Clinical Practice, 2011
Iatrogenic hypoglycemia is the limiting factor in the glycemic control of diabetes. It causes recurrent symptomatic and sometimes, at least temporally, disabling episodes in most people with type 1 diabetes, as well as in many with advanced type 2 diabetes.
openaire +2 more sources
Iatrogenic hypoglycemia is the limiting factor in the glycemic control of diabetes. It causes recurrent symptomatic and sometimes, at least temporally, disabling episodes in most people with type 1 diabetes, as well as in many with advanced type 2 diabetes.
openaire +2 more sources
Unawareness of Hypoglycemia by Insulin-Dependent Diabetics
Hormone and Metabolic Research, 1990After several years of insulin therapy, about 20% of insulin-dependent diabetics have little or no perception of hypoglycaemia because of a loss of the adrenergic warning symptoms. This defect, poorly correlated with the presence of autonomic neuropathy, has been classically explained by a defect in the catecholamine secretion. We compared the hormonal
A, Grimaldi +8 more
openaire +2 more sources