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Hypoglycemic Activity of Oral Hypoglycemics with Increased Hydrophilicity
Journal of Pharmaceutical Sciences, 1981The effect of increasing the hydrophilicity of acetohexamide and tolbutamide with hydroxypropyl methylcellulose and methylcellulose on drug dissolution and hypoglycemic activity in rats was examined. The dissolution rate of both drugs was increased according to the type and concentration of the polymer.
S A, Said, H I, Al-Shora
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Hypoglycemic Symptoms and the Hypoglycemic Experience
Psychosomatics, 1969• The variety of the symptoms and the vagueness of the emotional distress which the pa tients with hypoglycemic episodes endure have long provided the physician with a baf fling battery of findings and complaints. In order to construct a useful foundation for helping patients in distress, it is necessary to have an organized and coherent under ...
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Transient Hypoglycemic Hemiplegia
Archives of Internal Medicine, 1964In this paper, the clinical features and the theories of pathogenesis of transient hypoglycemic hemiplegia will be summarized. Report of a Case History. —A 22-year-old white male was hosiptalized because of the sudden development of hemiplegia. He was a ketosis-prone diabetic of nine years' duration.
B M, MONTGOMERY, C A, PINNER
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AACN Advanced Critical Care, 1992
Optimal control of blood glucose requires a balance of diet, exercise, and in some cases, medications. Many factors can cause a state of imbalance, resulting in extremes of glucose control. Hypoglycemia is defined generally as a blood glucose level lower than 50 mg/dL.
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Optimal control of blood glucose requires a balance of diet, exercise, and in some cases, medications. Many factors can cause a state of imbalance, resulting in extremes of glucose control. Hypoglycemia is defined generally as a blood glucose level lower than 50 mg/dL.
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Seminars in Neonatology, 2001
Hypoglycemia frequently occurs in newborn infants who previously have suffered asphyxia, who are offspring of diabetic mothers, or who are low birthweight for gestational age (IUGR). Many infants who are hypoglycemic do not exhibit clinical manifestations, while others are symptomatic and at risk for the occurrence of permanent brain damage.
R C, Vannucci, S J, Vannucci
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Hypoglycemia frequently occurs in newborn infants who previously have suffered asphyxia, who are offspring of diabetic mothers, or who are low birthweight for gestational age (IUGR). Many infants who are hypoglycemic do not exhibit clinical manifestations, while others are symptomatic and at risk for the occurrence of permanent brain damage.
R C, Vannucci, S J, Vannucci
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Approach to the Hypoglycemic Patient
Emergency Medicine Clinics of North America, 2023Hypoglycemia is commonly encountered in the emergency department. Patients can present with a myriad of symptoms and its presentation can mimic other more serious diagnoses. Despite the relative ease of its management, clinicians often miss the diagnosis or mismanage it even when discovered.
Molly, Chang, George C, Willis
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Primary Care: Clinics in Office Practice, 1977
Oral agents should not be used in the treatment of patients with asymptomatic maturity-onset diabetes. The indication for sulfonylureas is symptomatic maturity-onset diabetes or excessive hyperglycemia--fasting blood sugar over 300 mg per 100 ml--in the elderly patient who cannot or will not take insulin. The use of biguanides cannot be recommended.
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Oral agents should not be used in the treatment of patients with asymptomatic maturity-onset diabetes. The indication for sulfonylureas is symptomatic maturity-onset diabetes or excessive hyperglycemia--fasting blood sugar over 300 mg per 100 ml--in the elderly patient who cannot or will not take insulin. The use of biguanides cannot be recommended.
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Metabolic Brain Disease, 2004
Hypoglycemia was long considered to kill neurons by depriving them of glucose. We now know that hypoglycemia kills neurons actively from without, rather than by starvation from within. Hypoglycemia only causes neuronal death when the EEG becomes flat. This usually occurs after glucose levels have fallen below 1 mM (18 mg/dl) for some period, depending ...
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Hypoglycemia was long considered to kill neurons by depriving them of glucose. We now know that hypoglycemia kills neurons actively from without, rather than by starvation from within. Hypoglycemia only causes neuronal death when the EEG becomes flat. This usually occurs after glucose levels have fallen below 1 mM (18 mg/dl) for some period, depending ...
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New England Journal of Medicine, 1989
ORAL hypoglycemic agents are commonly prescribed drugs. In the United States they account for about 1 percent of all prescriptions.1 This review discusses the pharmacology, mechanisms of action, ef...
John A. Oates +2 more
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ORAL hypoglycemic agents are commonly prescribed drugs. In the United States they account for about 1 percent of all prescriptions.1 This review discusses the pharmacology, mechanisms of action, ef...
John A. Oates +2 more
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Medical Clinics of North America, 1988
The sulfonylureas remain the most important oral agents, although their chronic hypoglycemic actions are still unexplained and the evidence on their relative efficacy is inconclusive. Data on relative safety suggest that chlorpropamide is the most toxic sulfonylurea but glyburide causes dangerous hypoglycemia as often as chlorpropamide.
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The sulfonylureas remain the most important oral agents, although their chronic hypoglycemic actions are still unexplained and the evidence on their relative efficacy is inconclusive. Data on relative safety suggest that chlorpropamide is the most toxic sulfonylurea but glyburide causes dangerous hypoglycemia as often as chlorpropamide.
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