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Association between use of oral hypoglycemic agents in Japanese patients with type 2 diabetes mellitus and risk of depression: A retrospective cohort study. [PDF]
Pharmacol Res Perspect, 2019 Akimoto H +5 more
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New England Journal of Medicine, 1989
ORAL hypoglycemic agents are commonly prescribed drugs. In the United States they account for about 1 percent of all prescriptions.1 This review discusses the pharmacology, mechanisms of action, ef...
John E Gerich +2 more
exaly +3 more sources
ORAL hypoglycemic agents are commonly prescribed drugs. In the United States they account for about 1 percent of all prescriptions.1 This review discusses the pharmacology, mechanisms of action, ef...
John E Gerich +2 more
exaly +3 more sources
Oral Hypoglycemic Agents in Pregnancy
Obstetrics and Gynecology Clinics of North America, 2011Multiple studies have been published illustrating the use of oral hypoglycemic agents in pregnancy. Glyburide and metformin have been shown to be as effective as insulin for the treatment of gestational diabetes. Both are safe with breastfeeding. Although both glyburide and metformin appear safe for the treatment of type 2 diabetes mellitus, more ...
Jerrie S Refuerzo
exaly +3 more sources
Conformational analysis of non-sulfonylurea hypoglycemic agents of the meglitinide family [PDF]
Biochemical Pharmacology, 1995 Non-sulfonylurea hypoglycemic agents of the meglitinide family such as S3075, repaglinide, KAD-1229, and A-4166, were found to display a comparable U-shaped conformation by molecular modelling, with hydrophobic cycles placed at the extremity of each ...
Laurence Lins +2 more
exaly +2 more sources
Primary Care: Clinics in Office Practice, 1977
Oral agents should not be used in the treatment of patients with asymptomatic maturity-onset diabetes. The indication for sulfonylureas is symptomatic maturity-onset diabetes or excessive hyperglycemia--fasting blood sugar over 300 mg per 100 ml--in the elderly patient who cannot or will not take insulin. The use of biguanides cannot be recommended.
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Oral agents should not be used in the treatment of patients with asymptomatic maturity-onset diabetes. The indication for sulfonylureas is symptomatic maturity-onset diabetes or excessive hyperglycemia--fasting blood sugar over 300 mg per 100 ml--in the elderly patient who cannot or will not take insulin. The use of biguanides cannot be recommended.
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Medical Clinics of North America, 1988
The sulfonylureas remain the most important oral agents, although their chronic hypoglycemic actions are still unexplained and the evidence on their relative efficacy is inconclusive. Data on relative safety suggest that chlorpropamide is the most toxic sulfonylurea but glyburide causes dangerous hypoglycemia as often as chlorpropamide.
openaire +4 more sources
The sulfonylureas remain the most important oral agents, although their chronic hypoglycemic actions are still unexplained and the evidence on their relative efficacy is inconclusive. Data on relative safety suggest that chlorpropamide is the most toxic sulfonylurea but glyburide causes dangerous hypoglycemia as often as chlorpropamide.
openaire +4 more sources
Archives of Internal Medicine, 1960
In early 1942 while investigating the effect of isopropylthiodiazole (2254 RP) in typhoid fever, M. Janbon and co-workers in the Infectious Disease Clinic at Montpellier Medical School in France found that this sulfanilamide derivative produced signs and symptoms resembling hypoglycemia.
W G, TOMHAVE, W J, KUHL
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In early 1942 while investigating the effect of isopropylthiodiazole (2254 RP) in typhoid fever, M. Janbon and co-workers in the Infectious Disease Clinic at Montpellier Medical School in France found that this sulfanilamide derivative produced signs and symptoms resembling hypoglycemia.
W G, TOMHAVE, W J, KUHL
openaire +3 more sources
Pediatrics, 1969
I noted with interest the article by Drs. Adam and Schwartz, "Should Oral Hypoglycemic Agents Be Used in Pediatric and Pregnant Patients?" (Pediatrics, 42:819, 1968). In regard to juvenile diabetics, his conclusions were an echo of what usually appears in the ped iatric literature, namely, these drugs have no place in the management of any pediatric ...
openaire +2 more sources
I noted with interest the article by Drs. Adam and Schwartz, "Should Oral Hypoglycemic Agents Be Used in Pediatric and Pregnant Patients?" (Pediatrics, 42:819, 1968). In regard to juvenile diabetics, his conclusions were an echo of what usually appears in the ped iatric literature, namely, these drugs have no place in the management of any pediatric ...
openaire +2 more sources
Oral Hypoglycemic Agents in Pregnancy
Obstetrical & Gynecological Survey, 2004Pregnancies in diabetic women are associated with increased risk of spontaneous abortion, congenital malformations, preeclampsia, preterm labor, macrosomia, shoulder dystocia, and cesarean section. Advances in antepartum cares and strict adherence to dietary and insulin regimens have been shown to significantly reduce the rate of maternal morbidity as ...
Nam D, Tran +2 more
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Salicylates as Hypoglycemic Agents
Diabetes Care, 1982Salicylates lower blood sugar and enhance glucose-stimulated insulin secretion in normal and diabetic man. Although the hypoglycemic effect appears to be mediated by enhanced insulin secretion, extrapancreatic mechanisms cannot be excluded. The mechanism of the enhanced insulin secretion appears to be mediated by prostaglandin synthesis inhibition. The
openaire +2 more sources