Results 11 to 20 of about 41,302 (312)

Metabolic Disorders and Male Hypogonadotropic Hypogonadism

Frontiers in Endocrinology, 2019
Several studies highlight that testosterone deficiency is associated with, and predicts, an increased risk of developing metabolic disorders, and, on the other hand, is highly prevalent in obesity, metabolic syndrome and type-2 diabetes mellitus.
Rosario Pivonello, Davide Menafra, Enrico Riccio, Francesco Garifalos, Marco Mazzella, Cristina de Angelis, Annamaria Colao   +6 more
doaj   +2 more sources

New findings in oligogenic inheritance of congenital hypogonadotropic hypogonadism

Archives of Medical Science, 2020
Introduction Congenital hypogonadotropic hypogonadism results from a dysfunction of the hypothalamic-pituitary-gonadal axis, which is essential for the development and function of the reproductive system. It may be associated with anosmia, referred to as
Agnieszka Gach, Iwona Pinkier, Urszula Wysocka, Kinga Sałacińska, Dominik Salachna, Maria Szarras-Czapnik, Aleksandra Pietrzyk, Agata Sakowicz, Anna Nykel, Lena Rutkowska, Magda Rybak-Krzyszkowska, Magda Socha, Aleksander Jamsheer, Lucjusz Jakubowski   +13 more
doaj   +2 more sources

Normosmic idiopathic hypogonadotropic hypogonadism due to a novel GNRH1 variant in two siblings

Endocrinology, Diabetes & Metabolism Case Reports, 2020
Hypogonadotropic hypogonadism is characterised by insufficient secretion of pituitary gonadotropins resulting in delayed puberty, anovulation and azoospermia. When hypogonadotropic hypogonadism occurs in the absence of structural or functional lesions of
Satyanarayana V Sagi, Hareesh Joshi, Emily Whiles, Mondy Hikmat, Vijith R Puthi, Jane MacDougall, Sarah L Spiden, Gavin Fuller, Soo-Mi Park, Samson O Oyibo   +9 more
doaj   +2 more sources

New perspectives in functional hypogonadotropic hypogonadism: beyond late onset hypogonadism [PDF]

Frontiers in Endocrinology, 2023
Functional hypogonadotropic hypogonadism (FHH) is an increasingly frequent condition, whose pathological mechanisms are not yet fully clarified. The concept of FHH has now completely replaced that of late onset hypogonadism, that only concerned the ...
Matteo Spaziani, Francesco Carlomagno, C Tarantino, Francesco Angelini, Ludovica Vincenzi, Daniele Gianfrilli   +5 more
openalex   +2 more sources

A New Cause of Obesity Syndrome Associated with a Mutation in the Carboxypeptidase Gene Detected in Three Siblings with Obesity, Intellectual Disability and Hypogonadotropic Hypogonadism

JCRPE, 2021
Objective:Carboxypeptidase E (CPE) plays a critical role in the biosynthesis of peptide hormones and neuropeptides in the endocrine system and central nervous system.
Asude Durmaz, Ayça Aykut, Tahir Atik, Samim Özen, Durdugül Ayyıldız Emecen, Aysun Ata, Esra Işık, Damla Gökşen, Özgür Çoğulu, Ferda Özkınay   +9 more
doaj   +2 more sources

Psychological Aspects of Congenital Hypogonadotropic Hypogonadism

Frontiers in Endocrinology, 2019
Congenital hypogonadotropic hypogonadism/Kallmann syndrome (CHH/KS) is a rare, treatable form of infertility. Like other rare disease patients, individuals with CHH/KS frequently experience feelings of isolation, shame, and alienation.
Andrew A. Dwyer, Andrew A. Dwyer, Neil Smith, Richard Quinton   +3 more
doaj   +2 more sources

Gonadotropin-Releasing Hormone Receptor (GnRHR) and Hypogonadotropic Hypogonadism

International Journal of Molecular Sciences, 2023
Human sexual and reproductive development is regulated by the hypothalamic-pituitary-gonadal (HPG) axis, which is primarily controlled by the gonadotropin-releasing hormone (GnRH) acting on its receptor (GnRHR).
P. Fanis, V. Neocleous, Irene Papapetrou, L. Phylactou, N. Skordis   +4 more
semanticscholar   +1 more source

Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis

European Journal of Endocrinology, 2023
Objective Hypogonadotropic hypogonadism is characterized by inadequate secretion of pituitary gonadotropins, leading to absent, partial, or arrested puberty.
E. Alexander, Duaa Faruqi, Robert Farquhar, Ayesha Unadkat, Kyla Ng Yin, Rebecca B. Hoskyns, Rachel Varughese, Sasha R. Howard   +7 more
semanticscholar   +1 more source

Genetic architecture of self-limited delayed puberty and congenital hypogonadotropic hypogonadism

Frontiers in Endocrinology, 2023
Distinguishing between self limited delayed puberty (SLDP) and congenital hypogonadotropic hypogonadism (CHH) may be tricky as they share clinical and biochemical characteristics. and appear to lie within the same clinical spectrum.
V. Vezzoli, Faris Hrvat, G. Goggi, S. Federici, B. Cangiano, R. Quinton, L. Persani, M. Bonomi   +7 more
semanticscholar   +1 more source

NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice

Science Translational Medicine, 2022
The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction.
Konstantina Chachlaki, A. Messina, Virginia Delli, Valérie Leysen, Csilla Maurnyi, Chieko Huber, Gaetan Ternier, K. Skrapits, Georgios E. Papadakis, S. Shruti, Maria Kapanidou, Xu Cheng, James Acierno, Jesse Rademaker, S. Rasika, R. Quinton, M. Niedziela, D. l'Allemand, D. Pignatelli, Mirjam Dirlewander, M. Lang-Muritano, P. Kempf, S. Catteau-jonard, N. Niederländer, P. Ciofi, M. Tena-Sempere, J. Garthwaite, L. Storme, P. Avan, E. Hrabovszky, A. Carleton, F. Santoni, P. Giacobini, N. Pitteloud, V. Prévot   +34 more
semanticscholar   +1 more source