Results 111 to 120 of about 544 (156)

Molecular genetics of adult‐type hypolactasia

Annals of Medicine, 2005
Adult-type hypolactasia (lactase non-persistence; primary lactose malabsorption) is characterized by the down-regulation of the lactase enzyme activity in the intestinal wall after weaning. The down-regulation is genetically determined and a mutation has occurred that has made part of mankind tolerate milk (lactase persistence).
Irma Järvelä
exaly   +3 more sources

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Genetics and Epidemiology of Adult-type Hypolactasia

Scandinavian Journal of Gastroenterology, 1994
The prevalence of adult-type hypolactasia varies from less than 5% to almost 100% between different populations of the world. The lowest prevalence has been found in northwestern Europe, around the North Sea, and the highest prevalence in the Far East. The reason for the variation is that selective (primary) hypolactasia is genetically determined by an
T Sahi
exaly   +3 more sources

BREATH HYDROGEN AS A DIAGNOSTIC METHOD FOR HYPOLACTASIA

Lancet, The, 1975
Breath hydrogen (H2), collected by end-expiratory sampling, was measured in twenty-five patients with abdominal symptoms or diarrhoea after ingesting 50 g. of lactose. This was compared with established tests of hypolactasia. Fifteen patients with a blood-glucose rise of more than 20 mg. per 100 ml.
L M Blendis, G Metz, D J Jenkins
exaly   +3 more sources

Diagnosis of Hypolactasia and Lactose Malabsorption

Scandinavian Journal of Gastroenterology, 1994
The article briefly describes the various methods that are available for diagnosing hypolactasia. Special attention is drawn to the fact that different methods are useful at different levels of the health care organization. When the test result indicates lactose malabsorption, general malabsorption should be excluded by a glucose-galactose tolerance ...
exaly   +3 more sources

Clinical Picture of Hypolactasia and Lactose Intolerance

Scandinavian Journal of Gastroenterology, 1994
Selective adult-type hypolactasia, the main cause of primary malabsorption of lactose, shows considerable variation in terms of its symptoms, which mainly depend on the amount of milk consumption. The article discusses congenital lactase deficiency and familial lactose intolerance.
K Villako
exaly   +3 more sources

Comparison of Indirect Diagnostic Methods for Hypolactasia

Scandinavian Journal of Gastroenterology, 1988
The aim of this study was to continue our previously published work and to compare the different indirect diagnostic methods for hypolactasia with the lactase to sucrase ratio obtained by jejunal biopsy. The following tests were performed in 63 adult patients: the breath hydrogen test, the lactose tolerance test with ethanol (serum galactose ...
M Isokoski, M Jauhiainen
exaly   +3 more sources

Cellular basis of adult‐type hypolactasia

Acta Paediatrica, 1994
In the proximal jejunum and distal ileum of adult rabbits and rats, the lactase protein and lactase activity are present only in patches of enterocytes, located principally on the lower part of the villi, whereas in the mid‐small intestine, lactase is present in all the villus enterocytes.
S. Auricchio, MAIURI, Luigi
openaire   +6 more sources

Hypolactasia and Ulcerative Colitis

Gastroenterology, 1973
The disaccharidase activity in British patients with ulcerative colitis did not differ significantly from that found in healthy British volunteers. Nine of the 72 patients with ulcerative colitis had definite evidence of hypolactasia (12.5%), which is only slightly higher than the incidence in the healthy volunteers, in whom two out of 21 had ...
A S, Peña, S C, Truelove
openaire   +2 more sources

Hypolactasia and the Irritable Colon Syndrome

Scandinavian Journal of Gastroenterology, 1972
Jejunal biopsy with disaccharidase assay has been performed on 81 patients with the irritable colon syndrome. Most of the patients were British natives and of British stock. Nine of them (12.3%) had hypolactasia, a proportion which is only a little higher than has been found in healthy British volunteers and in other control subjects. A small number of
A S, Pena, S C, Truelove
exaly   +3 more sources

Hypolactasia and Lactase Persistence Historical Review and the Terminology

Scandinavian Journal of Gastroenterology, 1994
Lactase (more precisely lactase-phlorizin hydrolase) is located in the brush border of the small intestinal enterocytes and is responsible for the hydrolysis of dietary lactose. The earliest studies on lactase activity in mammals were published around the turn of the century.
T Sahi
exaly   +3 more sources